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Bioanalytical Assay Development and Validation for the Pharmacokinetic Study of GMC1, a Novel FKBP52 Co-chaperone Inhibitor for Castration Resistant Prostate Cancer

Background: GMC1 (2-(1H-benzimidazol-2-ylsulfanyl)-N-[(Z)-(4-methoxyphenyl) methylideneamino] acetamide) effectively inhibits androgen receptor function by binding directly to FKBP52. This is a novel mechanism for the treatment of castration resistant prostate cancer (CRPC). Methods: an LC-MS/MS met...

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Detalles Bibliográficos
Autores principales:	Ekpenyong, Oscar, Cooper, Candace, Ma, Jing, Guy, Naihsuan C., Payan, Ashley N., Ban, Fuqiang, Cherkasov, Artem, Cox, Marc B., Liang, Dong, Xie, Huan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698315/ https://www.ncbi.nlm.nih.gov/pubmed/33202977 http://dx.doi.org/10.3390/ph13110386

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