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Ultra-Processed Food Intake and Smoking Interact in Relation with Colorectal Adenomas

Smoking and ultra-processed foods (UPFs), a substantial part of the western diet, have been suggested to have a potential carcinogenic effect, though epidemiologic data are lacking. We aimed to examine the association between high UPF intake and colorectal adenomas, and to test the interaction with...

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Autores principales: Fliss-Isakov, Naomi, Zelber-Sagi, Shira, Ivancovsky-Wajcman, Dana, Shibolet, Oren, Kariv, Revital
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698317/
https://www.ncbi.nlm.nih.gov/pubmed/33202603
http://dx.doi.org/10.3390/nu12113507
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author Fliss-Isakov, Naomi
Zelber-Sagi, Shira
Ivancovsky-Wajcman, Dana
Shibolet, Oren
Kariv, Revital
author_facet Fliss-Isakov, Naomi
Zelber-Sagi, Shira
Ivancovsky-Wajcman, Dana
Shibolet, Oren
Kariv, Revital
author_sort Fliss-Isakov, Naomi
collection PubMed
description Smoking and ultra-processed foods (UPFs), a substantial part of the western diet, have been suggested to have a potential carcinogenic effect, though epidemiologic data are lacking. We aimed to examine the association between high UPF intake and colorectal adenomas, and to test the interaction with smoking. In a case-control study among consecutive subjects undergoing colonoscopy in a tertiary center during 2010–2015, UPF intake and smoking were compared between cases with colorectal adenomas and controls. Within 652 participants (cases, n = 294 and controls, n = 358), high UPF intake (defined as percent of kcal from UPF above the study sample upper tertile) was positively associated with adenomas (Odds ratio (OR) = 1.75, 95% Confidence interval (CI) 1.14–2.68), advanced and proximal adenomas (OR = 2.17, 1.29–3.65 and OR = 2.38, 1.37–4.11) among the whole study sample; and with adenomas (OR = 3.54, 1.90–6.61), non-advanced adenomas (OR = 2.60, 1.20–5.63), advanced adenomas (OR = 4.76, 2.20–10.30), proximal adenomas (OR = 6.23, 2.67–14.52), and distal adenomas (OR = 2.49, 1.21–5.13) among smokers. Additionally, a dose-dependent association was observed between tertiles of UPF intake and adenomas only among smokers (p for trend < 0.001). A significant interaction between smoking and high UPF intake was detected (p for interaction = 0.004). High intake of UPFs is strongly and independently associated with colorectal adenomas, especially advanced and proximal adenoma, and interacts with smoking. Results highlight smokers as more susceptible to the negative health effects of UPF consumption on colorectal neoplasia.
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spelling pubmed-76983172020-11-29 Ultra-Processed Food Intake and Smoking Interact in Relation with Colorectal Adenomas Fliss-Isakov, Naomi Zelber-Sagi, Shira Ivancovsky-Wajcman, Dana Shibolet, Oren Kariv, Revital Nutrients Article Smoking and ultra-processed foods (UPFs), a substantial part of the western diet, have been suggested to have a potential carcinogenic effect, though epidemiologic data are lacking. We aimed to examine the association between high UPF intake and colorectal adenomas, and to test the interaction with smoking. In a case-control study among consecutive subjects undergoing colonoscopy in a tertiary center during 2010–2015, UPF intake and smoking were compared between cases with colorectal adenomas and controls. Within 652 participants (cases, n = 294 and controls, n = 358), high UPF intake (defined as percent of kcal from UPF above the study sample upper tertile) was positively associated with adenomas (Odds ratio (OR) = 1.75, 95% Confidence interval (CI) 1.14–2.68), advanced and proximal adenomas (OR = 2.17, 1.29–3.65 and OR = 2.38, 1.37–4.11) among the whole study sample; and with adenomas (OR = 3.54, 1.90–6.61), non-advanced adenomas (OR = 2.60, 1.20–5.63), advanced adenomas (OR = 4.76, 2.20–10.30), proximal adenomas (OR = 6.23, 2.67–14.52), and distal adenomas (OR = 2.49, 1.21–5.13) among smokers. Additionally, a dose-dependent association was observed between tertiles of UPF intake and adenomas only among smokers (p for trend < 0.001). A significant interaction between smoking and high UPF intake was detected (p for interaction = 0.004). High intake of UPFs is strongly and independently associated with colorectal adenomas, especially advanced and proximal adenoma, and interacts with smoking. Results highlight smokers as more susceptible to the negative health effects of UPF consumption on colorectal neoplasia. MDPI 2020-11-14 /pmc/articles/PMC7698317/ /pubmed/33202603 http://dx.doi.org/10.3390/nu12113507 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fliss-Isakov, Naomi
Zelber-Sagi, Shira
Ivancovsky-Wajcman, Dana
Shibolet, Oren
Kariv, Revital
Ultra-Processed Food Intake and Smoking Interact in Relation with Colorectal Adenomas
title Ultra-Processed Food Intake and Smoking Interact in Relation with Colorectal Adenomas
title_full Ultra-Processed Food Intake and Smoking Interact in Relation with Colorectal Adenomas
title_fullStr Ultra-Processed Food Intake and Smoking Interact in Relation with Colorectal Adenomas
title_full_unstemmed Ultra-Processed Food Intake and Smoking Interact in Relation with Colorectal Adenomas
title_short Ultra-Processed Food Intake and Smoking Interact in Relation with Colorectal Adenomas
title_sort ultra-processed food intake and smoking interact in relation with colorectal adenomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698317/
https://www.ncbi.nlm.nih.gov/pubmed/33202603
http://dx.doi.org/10.3390/nu12113507
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