The Role of Histone Variants in the Epithelial-To-Mesenchymal Transition

The epithelial-to-mesenchymal transition (EMT) is a physiological process activated during early embryogenesis, which continues to shape tissues and organs later on. It is also hijacked by tumor cells during metastasis. The regulation of EMT has been the focus of many research groups culminating in...

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Autores principales: Lone, Imtiaz Nisar, Sengez, Burcu, Hamiche, Ali, Dimitrov, Stefan, Alotaibi, Hani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698467/
https://www.ncbi.nlm.nih.gov/pubmed/33213091
http://dx.doi.org/10.3390/cells9112499
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author Lone, Imtiaz Nisar
Sengez, Burcu
Hamiche, Ali
Dimitrov, Stefan
Alotaibi, Hani
author_facet Lone, Imtiaz Nisar
Sengez, Burcu
Hamiche, Ali
Dimitrov, Stefan
Alotaibi, Hani
author_sort Lone, Imtiaz Nisar
collection PubMed
description The epithelial-to-mesenchymal transition (EMT) is a physiological process activated during early embryogenesis, which continues to shape tissues and organs later on. It is also hijacked by tumor cells during metastasis. The regulation of EMT has been the focus of many research groups culminating in the last few years and resulting in an elaborate transcriptional network buildup. However, the implication of epigenetic factors in the control of EMT is still in its infancy. Recent discoveries pointed out that histone variants, which are key epigenetic players, appear to be involved in EMT control. This review summarizes the available data on histone variants’ function in EMT that would contribute to a better understanding of EMT itself and EMT-related diseases.
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spelling pubmed-76984672020-11-29 The Role of Histone Variants in the Epithelial-To-Mesenchymal Transition Lone, Imtiaz Nisar Sengez, Burcu Hamiche, Ali Dimitrov, Stefan Alotaibi, Hani Cells Review The epithelial-to-mesenchymal transition (EMT) is a physiological process activated during early embryogenesis, which continues to shape tissues and organs later on. It is also hijacked by tumor cells during metastasis. The regulation of EMT has been the focus of many research groups culminating in the last few years and resulting in an elaborate transcriptional network buildup. However, the implication of epigenetic factors in the control of EMT is still in its infancy. Recent discoveries pointed out that histone variants, which are key epigenetic players, appear to be involved in EMT control. This review summarizes the available data on histone variants’ function in EMT that would contribute to a better understanding of EMT itself and EMT-related diseases. MDPI 2020-11-17 /pmc/articles/PMC7698467/ /pubmed/33213091 http://dx.doi.org/10.3390/cells9112499 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lone, Imtiaz Nisar
Sengez, Burcu
Hamiche, Ali
Dimitrov, Stefan
Alotaibi, Hani
The Role of Histone Variants in the Epithelial-To-Mesenchymal Transition
title The Role of Histone Variants in the Epithelial-To-Mesenchymal Transition
title_full The Role of Histone Variants in the Epithelial-To-Mesenchymal Transition
title_fullStr The Role of Histone Variants in the Epithelial-To-Mesenchymal Transition
title_full_unstemmed The Role of Histone Variants in the Epithelial-To-Mesenchymal Transition
title_short The Role of Histone Variants in the Epithelial-To-Mesenchymal Transition
title_sort role of histone variants in the epithelial-to-mesenchymal transition
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698467/
https://www.ncbi.nlm.nih.gov/pubmed/33213091
http://dx.doi.org/10.3390/cells9112499
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