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A Novel Sub-Lineage of Chikungunya Virus East/Central/South African Genotype Indian Ocean Lineage Caused Sequential Outbreaks in Bangladesh and Thailand

In recent decades, chikungunya virus (CHIKV) has become geographically widespread. In 2004, the CHIKV East/Central/South African (ECSA) genotype moved from Africa to Indian ocean islands and India followed by a large epidemic in Southeast Asia. In 2013, the CHIKV Asian genotype drove an outbreak in...

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Autores principales: Phadungsombat, Juthamas, Imad, Hisham, Rahman, Mizanur, Nakayama, Emi E., Kludkleeb, Sajikapon, Ponam, Thitiya, Rahim, Rummana, Hasan, Abu, Poltep, Kanaporn, Yamanaka, Atsushi, Matsee, Wasin, Piyaphanee, Watcharapong, Phumratanaprapin, Weerapong, Shioda, Tatsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698486/
https://www.ncbi.nlm.nih.gov/pubmed/33213040
http://dx.doi.org/10.3390/v12111319
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author Phadungsombat, Juthamas
Imad, Hisham
Rahman, Mizanur
Nakayama, Emi E.
Kludkleeb, Sajikapon
Ponam, Thitiya
Rahim, Rummana
Hasan, Abu
Poltep, Kanaporn
Yamanaka, Atsushi
Matsee, Wasin
Piyaphanee, Watcharapong
Phumratanaprapin, Weerapong
Shioda, Tatsuo
author_facet Phadungsombat, Juthamas
Imad, Hisham
Rahman, Mizanur
Nakayama, Emi E.
Kludkleeb, Sajikapon
Ponam, Thitiya
Rahim, Rummana
Hasan, Abu
Poltep, Kanaporn
Yamanaka, Atsushi
Matsee, Wasin
Piyaphanee, Watcharapong
Phumratanaprapin, Weerapong
Shioda, Tatsuo
author_sort Phadungsombat, Juthamas
collection PubMed
description In recent decades, chikungunya virus (CHIKV) has become geographically widespread. In 2004, the CHIKV East/Central/South African (ECSA) genotype moved from Africa to Indian ocean islands and India followed by a large epidemic in Southeast Asia. In 2013, the CHIKV Asian genotype drove an outbreak in the Americas. Since 2016, CHIKV has re-emerged in the Indian subcontinent and Southeast Asia. In the present study, CHIKVs were obtained from Bangladesh in 2017 and Thailand in 2019, and their nearly full genomes were sequenced. Phylogenetic analysis revealed that the recent CHIKVs were of Indian Ocean Lineage (IOL) of genotype ECSA, similar to the previous outbreak. However, these CHIKVs were all clustered into a new distinct sub-lineage apart from the past IOL CHIKVs, and they lacked an alanine-to-valine substitution at position 226 of the E1 envelope glycoprotein, which enhances CHIKV replication in Aedes albopictus. Instead, all the re-emerged CHIKVs possessed mutations of lysine-to-glutamic acid at position 211 of E1 and valine-to-alanine at position 264 of E2. Molecular clock analysis suggested that the new sub-lineage CHIKV was introduced to Bangladesh around late 2015 and Thailand in early 2017. These results suggest that re-emerged CHIKVs have acquired different adaptations than the previous CHIKVs.
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spelling pubmed-76984862020-11-29 A Novel Sub-Lineage of Chikungunya Virus East/Central/South African Genotype Indian Ocean Lineage Caused Sequential Outbreaks in Bangladesh and Thailand Phadungsombat, Juthamas Imad, Hisham Rahman, Mizanur Nakayama, Emi E. Kludkleeb, Sajikapon Ponam, Thitiya Rahim, Rummana Hasan, Abu Poltep, Kanaporn Yamanaka, Atsushi Matsee, Wasin Piyaphanee, Watcharapong Phumratanaprapin, Weerapong Shioda, Tatsuo Viruses Article In recent decades, chikungunya virus (CHIKV) has become geographically widespread. In 2004, the CHIKV East/Central/South African (ECSA) genotype moved from Africa to Indian ocean islands and India followed by a large epidemic in Southeast Asia. In 2013, the CHIKV Asian genotype drove an outbreak in the Americas. Since 2016, CHIKV has re-emerged in the Indian subcontinent and Southeast Asia. In the present study, CHIKVs were obtained from Bangladesh in 2017 and Thailand in 2019, and their nearly full genomes were sequenced. Phylogenetic analysis revealed that the recent CHIKVs were of Indian Ocean Lineage (IOL) of genotype ECSA, similar to the previous outbreak. However, these CHIKVs were all clustered into a new distinct sub-lineage apart from the past IOL CHIKVs, and they lacked an alanine-to-valine substitution at position 226 of the E1 envelope glycoprotein, which enhances CHIKV replication in Aedes albopictus. Instead, all the re-emerged CHIKVs possessed mutations of lysine-to-glutamic acid at position 211 of E1 and valine-to-alanine at position 264 of E2. Molecular clock analysis suggested that the new sub-lineage CHIKV was introduced to Bangladesh around late 2015 and Thailand in early 2017. These results suggest that re-emerged CHIKVs have acquired different adaptations than the previous CHIKVs. MDPI 2020-11-17 /pmc/articles/PMC7698486/ /pubmed/33213040 http://dx.doi.org/10.3390/v12111319 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Phadungsombat, Juthamas
Imad, Hisham
Rahman, Mizanur
Nakayama, Emi E.
Kludkleeb, Sajikapon
Ponam, Thitiya
Rahim, Rummana
Hasan, Abu
Poltep, Kanaporn
Yamanaka, Atsushi
Matsee, Wasin
Piyaphanee, Watcharapong
Phumratanaprapin, Weerapong
Shioda, Tatsuo
A Novel Sub-Lineage of Chikungunya Virus East/Central/South African Genotype Indian Ocean Lineage Caused Sequential Outbreaks in Bangladesh and Thailand
title A Novel Sub-Lineage of Chikungunya Virus East/Central/South African Genotype Indian Ocean Lineage Caused Sequential Outbreaks in Bangladesh and Thailand
title_full A Novel Sub-Lineage of Chikungunya Virus East/Central/South African Genotype Indian Ocean Lineage Caused Sequential Outbreaks in Bangladesh and Thailand
title_fullStr A Novel Sub-Lineage of Chikungunya Virus East/Central/South African Genotype Indian Ocean Lineage Caused Sequential Outbreaks in Bangladesh and Thailand
title_full_unstemmed A Novel Sub-Lineage of Chikungunya Virus East/Central/South African Genotype Indian Ocean Lineage Caused Sequential Outbreaks in Bangladesh and Thailand
title_short A Novel Sub-Lineage of Chikungunya Virus East/Central/South African Genotype Indian Ocean Lineage Caused Sequential Outbreaks in Bangladesh and Thailand
title_sort novel sub-lineage of chikungunya virus east/central/south african genotype indian ocean lineage caused sequential outbreaks in bangladesh and thailand
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698486/
https://www.ncbi.nlm.nih.gov/pubmed/33213040
http://dx.doi.org/10.3390/v12111319
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