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Viral Infections in Burn Patients: A State-Of-The-Art Review

Infections that are triggered by the accompanying immunosuppression in patients with burn wounds are very common regardless of age. Among burn patients, the most frequently diagnosed infections include the bacterial ones primarily caused by Pseudomonas aeruginosa or Klebsiella pneumonia, as well as...

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Autores principales: Baj, Jacek, Korona-Głowniak, Izabela, Buszewicz, Grzegorz, Forma, Alicja, Sitarz, Monika, Teresiński, Grzegorz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698518/
https://www.ncbi.nlm.nih.gov/pubmed/33213058
http://dx.doi.org/10.3390/v12111315
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author Baj, Jacek
Korona-Głowniak, Izabela
Buszewicz, Grzegorz
Forma, Alicja
Sitarz, Monika
Teresiński, Grzegorz
author_facet Baj, Jacek
Korona-Głowniak, Izabela
Buszewicz, Grzegorz
Forma, Alicja
Sitarz, Monika
Teresiński, Grzegorz
author_sort Baj, Jacek
collection PubMed
description Infections that are triggered by the accompanying immunosuppression in patients with burn wounds are very common regardless of age. Among burn patients, the most frequently diagnosed infections include the bacterial ones primarily caused by Pseudomonas aeruginosa or Klebsiella pneumonia, as well as fungal infections with the etiology of Candida spp. or Aspergillus spp. Besides, burn wounds are highly susceptible to viral infections mainly due to the impaired immune responses and defective functions of the immune cells within the wound microenvironment. The most prevalent viruses that invade burn wounds include herpes simplex virus (HSV), cytomegalovirus (CMV), human papilloma virus (HPV), and varicella zoster virus (VZV). Likewise, less prevalent infections such as those caused by the orf virus or Epstein–Barr Virus (EBV) might also occur in immunosuppressed burn patients. Viral infections result in increased morbidity and mortality rates in severely burned patients. Additionally, a positive correlation between the hospitalization duration and the severity of the viral infection has been demonstrated. Viral infections trigger the occurrence of various complications, ranging from mild symptoms to even fatal incidents. Accurate detection of viral infection is of great clinical importance because of the possibility for a quicker introduction of proper treatment therapy and shortening of hospitalization time. The aim of this paper is to provide a comprehensive review of the literature and summarize the findings regarding the most common viral infections in immunosuppressed burn patients.
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spelling pubmed-76985182020-11-29 Viral Infections in Burn Patients: A State-Of-The-Art Review Baj, Jacek Korona-Głowniak, Izabela Buszewicz, Grzegorz Forma, Alicja Sitarz, Monika Teresiński, Grzegorz Viruses Review Infections that are triggered by the accompanying immunosuppression in patients with burn wounds are very common regardless of age. Among burn patients, the most frequently diagnosed infections include the bacterial ones primarily caused by Pseudomonas aeruginosa or Klebsiella pneumonia, as well as fungal infections with the etiology of Candida spp. or Aspergillus spp. Besides, burn wounds are highly susceptible to viral infections mainly due to the impaired immune responses and defective functions of the immune cells within the wound microenvironment. The most prevalent viruses that invade burn wounds include herpes simplex virus (HSV), cytomegalovirus (CMV), human papilloma virus (HPV), and varicella zoster virus (VZV). Likewise, less prevalent infections such as those caused by the orf virus or Epstein–Barr Virus (EBV) might also occur in immunosuppressed burn patients. Viral infections result in increased morbidity and mortality rates in severely burned patients. Additionally, a positive correlation between the hospitalization duration and the severity of the viral infection has been demonstrated. Viral infections trigger the occurrence of various complications, ranging from mild symptoms to even fatal incidents. Accurate detection of viral infection is of great clinical importance because of the possibility for a quicker introduction of proper treatment therapy and shortening of hospitalization time. The aim of this paper is to provide a comprehensive review of the literature and summarize the findings regarding the most common viral infections in immunosuppressed burn patients. MDPI 2020-11-17 /pmc/articles/PMC7698518/ /pubmed/33213058 http://dx.doi.org/10.3390/v12111315 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Baj, Jacek
Korona-Głowniak, Izabela
Buszewicz, Grzegorz
Forma, Alicja
Sitarz, Monika
Teresiński, Grzegorz
Viral Infections in Burn Patients: A State-Of-The-Art Review
title Viral Infections in Burn Patients: A State-Of-The-Art Review
title_full Viral Infections in Burn Patients: A State-Of-The-Art Review
title_fullStr Viral Infections in Burn Patients: A State-Of-The-Art Review
title_full_unstemmed Viral Infections in Burn Patients: A State-Of-The-Art Review
title_short Viral Infections in Burn Patients: A State-Of-The-Art Review
title_sort viral infections in burn patients: a state-of-the-art review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698518/
https://www.ncbi.nlm.nih.gov/pubmed/33213058
http://dx.doi.org/10.3390/v12111315
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