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Novel Benchtop Magnetic Particle Spectrometer for Process Monitoring of Magnetic Nanoparticle Synthesis

Magnetic nanoparticles combine unique magnetic properties that can be used in a variety of biomedical applications for therapy and diagnostics. These applications place high demands on the magnetic properties of nanoparticles. Thus, research, development, and quality assurance of magnetic nanopartic...

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Autores principales: Löwa, Norbert, Gutkelch, Dirk, Welge, Ernst-Albrecht, Welz, Roland, Meier, Florian, Baki, Abdulkader, Bleul, Regina, Klein, Thorsten, Wiekhorst, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698567/
https://www.ncbi.nlm.nih.gov/pubmed/33213004
http://dx.doi.org/10.3390/nano10112277
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author Löwa, Norbert
Gutkelch, Dirk
Welge, Ernst-Albrecht
Welz, Roland
Meier, Florian
Baki, Abdulkader
Bleul, Regina
Klein, Thorsten
Wiekhorst, Frank
author_facet Löwa, Norbert
Gutkelch, Dirk
Welge, Ernst-Albrecht
Welz, Roland
Meier, Florian
Baki, Abdulkader
Bleul, Regina
Klein, Thorsten
Wiekhorst, Frank
author_sort Löwa, Norbert
collection PubMed
description Magnetic nanoparticles combine unique magnetic properties that can be used in a variety of biomedical applications for therapy and diagnostics. These applications place high demands on the magnetic properties of nanoparticles. Thus, research, development, and quality assurance of magnetic nanoparticles requires powerful analytical methods that are capable of detecting relevant structural and, above all, magnetic parameters. By directly coupling nanoparticle synthesis with magnetic detectors, relevant nanoparticle properties can be obtained and evaluated, and adjustments can be made to the manufacturing process in real time. This work presents a sensitive and fast magnetic detector for online characterization of magnetic nanoparticles during their continuous micromixer synthesis. The detector is based on the measurement of the nonlinear dynamic magnetic response of magnetic nanoparticles exposed to an oscillating excitation at a frequency of 25 kHz, a technique also known as magnetic particle spectroscopy. Our results underline the excellent suitability of the developed magnetic online detection for coupling with magnetic nanoparticle synthesis based on the micromixer approach. The proven practicability and reliability of the detector for process monitoring forms the basis for further application fields, e.g., as a monitoring tool for chromatographic separation processes.
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spelling pubmed-76985672020-11-29 Novel Benchtop Magnetic Particle Spectrometer for Process Monitoring of Magnetic Nanoparticle Synthesis Löwa, Norbert Gutkelch, Dirk Welge, Ernst-Albrecht Welz, Roland Meier, Florian Baki, Abdulkader Bleul, Regina Klein, Thorsten Wiekhorst, Frank Nanomaterials (Basel) Article Magnetic nanoparticles combine unique magnetic properties that can be used in a variety of biomedical applications for therapy and diagnostics. These applications place high demands on the magnetic properties of nanoparticles. Thus, research, development, and quality assurance of magnetic nanoparticles requires powerful analytical methods that are capable of detecting relevant structural and, above all, magnetic parameters. By directly coupling nanoparticle synthesis with magnetic detectors, relevant nanoparticle properties can be obtained and evaluated, and adjustments can be made to the manufacturing process in real time. This work presents a sensitive and fast magnetic detector for online characterization of magnetic nanoparticles during their continuous micromixer synthesis. The detector is based on the measurement of the nonlinear dynamic magnetic response of magnetic nanoparticles exposed to an oscillating excitation at a frequency of 25 kHz, a technique also known as magnetic particle spectroscopy. Our results underline the excellent suitability of the developed magnetic online detection for coupling with magnetic nanoparticle synthesis based on the micromixer approach. The proven practicability and reliability of the detector for process monitoring forms the basis for further application fields, e.g., as a monitoring tool for chromatographic separation processes. MDPI 2020-11-17 /pmc/articles/PMC7698567/ /pubmed/33213004 http://dx.doi.org/10.3390/nano10112277 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Löwa, Norbert
Gutkelch, Dirk
Welge, Ernst-Albrecht
Welz, Roland
Meier, Florian
Baki, Abdulkader
Bleul, Regina
Klein, Thorsten
Wiekhorst, Frank
Novel Benchtop Magnetic Particle Spectrometer for Process Monitoring of Magnetic Nanoparticle Synthesis
title Novel Benchtop Magnetic Particle Spectrometer for Process Monitoring of Magnetic Nanoparticle Synthesis
title_full Novel Benchtop Magnetic Particle Spectrometer for Process Monitoring of Magnetic Nanoparticle Synthesis
title_fullStr Novel Benchtop Magnetic Particle Spectrometer for Process Monitoring of Magnetic Nanoparticle Synthesis
title_full_unstemmed Novel Benchtop Magnetic Particle Spectrometer for Process Monitoring of Magnetic Nanoparticle Synthesis
title_short Novel Benchtop Magnetic Particle Spectrometer for Process Monitoring of Magnetic Nanoparticle Synthesis
title_sort novel benchtop magnetic particle spectrometer for process monitoring of magnetic nanoparticle synthesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698567/
https://www.ncbi.nlm.nih.gov/pubmed/33213004
http://dx.doi.org/10.3390/nano10112277
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