Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection

In patients coinfected with SARS-CoV-2 and HBV, liver injury was common. However, the interactions between SARS-CoV-2 and HBV coinfection remained unknown. Sixty-seven COVID-19 patients from the previous cohort were enrolled and classified into 2 groups (7 with HBsAg+ and 60 with HBsAg-). The associ...

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Detalles Bibliográficos
Autores principales: Yu, Rentao, Tan, Shun, Dan, Yunjie, Lu, Yanqiu, Zhang, Juan, Tan, Zhaoxia, He, Xiaoqing, Xiang, Xiaomei, Zhou, Yi, Guo, Yanzhi, Deng, Guohong, Chen, Yaokai, Tan, Wenting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698656/
https://www.ncbi.nlm.nih.gov/pubmed/33276282
http://dx.doi.org/10.1016/j.virol.2020.11.012
Descripción
Sumario:In patients coinfected with SARS-CoV-2 and HBV, liver injury was common. However, the interactions between SARS-CoV-2 and HBV coinfection remained unknown. Sixty-seven COVID-19 patients from the previous cohort were enrolled and classified into 2 groups (7 with HBsAg+ and 60 with HBsAg-). The association of HBV- and SARS-CoV-2-related markers were analyzed. During the acute course of SARS-CoV-2 infection, markers of HBV replication did not extensively fluctuate during SARS-CoV-2 infection. Coinfection with HBV did not extend the viral shedding cycle or incubation periods of SARS-CoV-2. Effects of SARS-CoV-2 on the dynamics of chronic HBV infection seemed not apparent. SARS-CoV-2 infection would not be the source of HBV reactivation in these individuals.

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