Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection

In patients coinfected with SARS-CoV-2 and HBV, liver injury was common. However, the interactions between SARS-CoV-2 and HBV coinfection remained unknown. Sixty-seven COVID-19 patients from the previous cohort were enrolled and classified into 2 groups (7 with HBsAg+ and 60 with HBsAg-). The associ...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Rentao, Tan, Shun, Dan, Yunjie, Lu, Yanqiu, Zhang, Juan, Tan, Zhaoxia, He, Xiaoqing, Xiang, Xiaomei, Zhou, Yi, Guo, Yanzhi, Deng, Guohong, Chen, Yaokai, Tan, Wenting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698656/
https://www.ncbi.nlm.nih.gov/pubmed/33276282
http://dx.doi.org/10.1016/j.virol.2020.11.012
_version_ 1783615880392867840
author Yu, Rentao
Tan, Shun
Dan, Yunjie
Lu, Yanqiu
Zhang, Juan
Tan, Zhaoxia
He, Xiaoqing
Xiang, Xiaomei
Zhou, Yi
Guo, Yanzhi
Deng, Guohong
Chen, Yaokai
Tan, Wenting
author_facet Yu, Rentao
Tan, Shun
Dan, Yunjie
Lu, Yanqiu
Zhang, Juan
Tan, Zhaoxia
He, Xiaoqing
Xiang, Xiaomei
Zhou, Yi
Guo, Yanzhi
Deng, Guohong
Chen, Yaokai
Tan, Wenting
author_sort Yu, Rentao
collection PubMed
description In patients coinfected with SARS-CoV-2 and HBV, liver injury was common. However, the interactions between SARS-CoV-2 and HBV coinfection remained unknown. Sixty-seven COVID-19 patients from the previous cohort were enrolled and classified into 2 groups (7 with HBsAg+ and 60 with HBsAg-). The association of HBV- and SARS-CoV-2-related markers were analyzed. During the acute course of SARS-CoV-2 infection, markers of HBV replication did not extensively fluctuate during SARS-CoV-2 infection. Coinfection with HBV did not extend the viral shedding cycle or incubation periods of SARS-CoV-2. Effects of SARS-CoV-2 on the dynamics of chronic HBV infection seemed not apparent. SARS-CoV-2 infection would not be the source of HBV reactivation in these individuals.
format Online
Article
Text
id pubmed-7698656
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-76986562020-12-01 Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection Yu, Rentao Tan, Shun Dan, Yunjie Lu, Yanqiu Zhang, Juan Tan, Zhaoxia He, Xiaoqing Xiang, Xiaomei Zhou, Yi Guo, Yanzhi Deng, Guohong Chen, Yaokai Tan, Wenting Virology Article In patients coinfected with SARS-CoV-2 and HBV, liver injury was common. However, the interactions between SARS-CoV-2 and HBV coinfection remained unknown. Sixty-seven COVID-19 patients from the previous cohort were enrolled and classified into 2 groups (7 with HBsAg+ and 60 with HBsAg-). The association of HBV- and SARS-CoV-2-related markers were analyzed. During the acute course of SARS-CoV-2 infection, markers of HBV replication did not extensively fluctuate during SARS-CoV-2 infection. Coinfection with HBV did not extend the viral shedding cycle or incubation periods of SARS-CoV-2. Effects of SARS-CoV-2 on the dynamics of chronic HBV infection seemed not apparent. SARS-CoV-2 infection would not be the source of HBV reactivation in these individuals. Elsevier Inc. 2021-01-15 2020-11-28 /pmc/articles/PMC7698656/ /pubmed/33276282 http://dx.doi.org/10.1016/j.virol.2020.11.012 Text en © 2020 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Yu, Rentao
Tan, Shun
Dan, Yunjie
Lu, Yanqiu
Zhang, Juan
Tan, Zhaoxia
He, Xiaoqing
Xiang, Xiaomei
Zhou, Yi
Guo, Yanzhi
Deng, Guohong
Chen, Yaokai
Tan, Wenting
Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection
title Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection
title_full Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection
title_fullStr Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection
title_full_unstemmed Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection
title_short Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection
title_sort effect of sars-cov-2 coinfection was not apparent on the dynamics of chronic hepatitis b infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698656/
https://www.ncbi.nlm.nih.gov/pubmed/33276282
http://dx.doi.org/10.1016/j.virol.2020.11.012
work_keys_str_mv AT yurentao effectofsarscov2coinfectionwasnotapparentonthedynamicsofchronichepatitisbinfection
AT tanshun effectofsarscov2coinfectionwasnotapparentonthedynamicsofchronichepatitisbinfection
AT danyunjie effectofsarscov2coinfectionwasnotapparentonthedynamicsofchronichepatitisbinfection
AT luyanqiu effectofsarscov2coinfectionwasnotapparentonthedynamicsofchronichepatitisbinfection
AT zhangjuan effectofsarscov2coinfectionwasnotapparentonthedynamicsofchronichepatitisbinfection
AT tanzhaoxia effectofsarscov2coinfectionwasnotapparentonthedynamicsofchronichepatitisbinfection
AT hexiaoqing effectofsarscov2coinfectionwasnotapparentonthedynamicsofchronichepatitisbinfection
AT xiangxiaomei effectofsarscov2coinfectionwasnotapparentonthedynamicsofchronichepatitisbinfection
AT zhouyi effectofsarscov2coinfectionwasnotapparentonthedynamicsofchronichepatitisbinfection
AT guoyanzhi effectofsarscov2coinfectionwasnotapparentonthedynamicsofchronichepatitisbinfection
AT dengguohong effectofsarscov2coinfectionwasnotapparentonthedynamicsofchronichepatitisbinfection
AT chenyaokai effectofsarscov2coinfectionwasnotapparentonthedynamicsofchronichepatitisbinfection
AT tanwenting effectofsarscov2coinfectionwasnotapparentonthedynamicsofchronichepatitisbinfection

Ejemplares similares