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Hypertensive Disorders of Pregnancy and Medication Use in the 2015 Pelotas (Brazil) Birth Cohort Study

Hypertensive disorders of pregnancy account for approximately 22% of all maternal deaths in Latin America and the Caribbean. Pharmacotherapies play an important role in preventing and reducing the occurrence of adverse outcomes. However, the patterns of medications used for treating women with hyper...

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Autores principales: Leal, Lisiane Freitas, Grandi, Sonia Marzia, Miranda, Vanessa Iribarrem Avena, Dal Pizzol, Tatiane da Silva, Platt, Robert William, da Silveira, Mariângela Freitas, Bertoldi, Andréa Dâmaso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698775/
https://www.ncbi.nlm.nih.gov/pubmed/33217917
http://dx.doi.org/10.3390/ijerph17228541
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author Leal, Lisiane Freitas
Grandi, Sonia Marzia
Miranda, Vanessa Iribarrem Avena
Dal Pizzol, Tatiane da Silva
Platt, Robert William
da Silveira, Mariângela Freitas
Bertoldi, Andréa Dâmaso
author_facet Leal, Lisiane Freitas
Grandi, Sonia Marzia
Miranda, Vanessa Iribarrem Avena
Dal Pizzol, Tatiane da Silva
Platt, Robert William
da Silveira, Mariângela Freitas
Bertoldi, Andréa Dâmaso
author_sort Leal, Lisiane Freitas
collection PubMed
description Hypertensive disorders of pregnancy account for approximately 22% of all maternal deaths in Latin America and the Caribbean. Pharmacotherapies play an important role in preventing and reducing the occurrence of adverse outcomes. However, the patterns of medications used for treating women with hypertensive disorders of pregnancy (HDP) living in this country is unclear. A population-based birth cohort study including 4262 women was conducted to describe the pattern of use of cardiovascular agents and acetylsalicylic acid between women with and without HDP in the 2015 Pelotas (Brazil) Birth Cohort. The prevalence of maternal and perinatal outcomes in this population was also assessed. HDP were classified according to Ministry of Health recommendations. Medications were defined using the Anatomical Therapeutic Chemical Classification System and the substance name. In this cohort, 1336 (31.3%) of women had HDP. Gestational hypertension was present in 636 (47.6%) women, 409 (30.6%) had chronic hypertension, 191 (14.3%) pre-eclampsia, and 89 (6.7%) pre-eclampsia superimposed on chronic hypertension. Approximately 70% of women with HDP reported not using any cardiovascular medications. Methyldopa in monotherapy was the most frequent treatment (16%), regardless of the type of HDP. Omega-3 was the medication most frequently reported by women without HDP. Preterm delivery, caesarean section, low birth weight, and neonatal intensive care admissions were more prevalent in women with HDP. Patterns of use of methyldopa were in-line with the Brazilian guidelines as the first-line therapy for HDP. However, the large number of women with HDP not using medications to manage HDP requires further investigation.
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spelling pubmed-76987752020-11-29 Hypertensive Disorders of Pregnancy and Medication Use in the 2015 Pelotas (Brazil) Birth Cohort Study Leal, Lisiane Freitas Grandi, Sonia Marzia Miranda, Vanessa Iribarrem Avena Dal Pizzol, Tatiane da Silva Platt, Robert William da Silveira, Mariângela Freitas Bertoldi, Andréa Dâmaso Int J Environ Res Public Health Article Hypertensive disorders of pregnancy account for approximately 22% of all maternal deaths in Latin America and the Caribbean. Pharmacotherapies play an important role in preventing and reducing the occurrence of adverse outcomes. However, the patterns of medications used for treating women with hypertensive disorders of pregnancy (HDP) living in this country is unclear. A population-based birth cohort study including 4262 women was conducted to describe the pattern of use of cardiovascular agents and acetylsalicylic acid between women with and without HDP in the 2015 Pelotas (Brazil) Birth Cohort. The prevalence of maternal and perinatal outcomes in this population was also assessed. HDP were classified according to Ministry of Health recommendations. Medications were defined using the Anatomical Therapeutic Chemical Classification System and the substance name. In this cohort, 1336 (31.3%) of women had HDP. Gestational hypertension was present in 636 (47.6%) women, 409 (30.6%) had chronic hypertension, 191 (14.3%) pre-eclampsia, and 89 (6.7%) pre-eclampsia superimposed on chronic hypertension. Approximately 70% of women with HDP reported not using any cardiovascular medications. Methyldopa in monotherapy was the most frequent treatment (16%), regardless of the type of HDP. Omega-3 was the medication most frequently reported by women without HDP. Preterm delivery, caesarean section, low birth weight, and neonatal intensive care admissions were more prevalent in women with HDP. Patterns of use of methyldopa were in-line with the Brazilian guidelines as the first-line therapy for HDP. However, the large number of women with HDP not using medications to manage HDP requires further investigation. MDPI 2020-11-18 2020-11 /pmc/articles/PMC7698775/ /pubmed/33217917 http://dx.doi.org/10.3390/ijerph17228541 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Leal, Lisiane Freitas
Grandi, Sonia Marzia
Miranda, Vanessa Iribarrem Avena
Dal Pizzol, Tatiane da Silva
Platt, Robert William
da Silveira, Mariângela Freitas
Bertoldi, Andréa Dâmaso
Hypertensive Disorders of Pregnancy and Medication Use in the 2015 Pelotas (Brazil) Birth Cohort Study
title Hypertensive Disorders of Pregnancy and Medication Use in the 2015 Pelotas (Brazil) Birth Cohort Study
title_full Hypertensive Disorders of Pregnancy and Medication Use in the 2015 Pelotas (Brazil) Birth Cohort Study
title_fullStr Hypertensive Disorders of Pregnancy and Medication Use in the 2015 Pelotas (Brazil) Birth Cohort Study
title_full_unstemmed Hypertensive Disorders of Pregnancy and Medication Use in the 2015 Pelotas (Brazil) Birth Cohort Study
title_short Hypertensive Disorders of Pregnancy and Medication Use in the 2015 Pelotas (Brazil) Birth Cohort Study
title_sort hypertensive disorders of pregnancy and medication use in the 2015 pelotas (brazil) birth cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698775/
https://www.ncbi.nlm.nih.gov/pubmed/33217917
http://dx.doi.org/10.3390/ijerph17228541
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