Cargando…

New Evidence on the Role of D-Aspartate Metabolism in Regulating Brain and Endocrine System Physiology: From Preclinical Observations to Clinical Applications

The endogenous amino acids serine and aspartate occur at high concentrations in free D-form in mammalian organs, including the central nervous system and endocrine glands. D-serine (D-Ser) is largely localized in the forebrain structures throughout pre and postnatal life. Pharmacologically, D-Ser pl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Usiello, Alessandro, Di Fiore, Maria Maddalena, De Rosa, Arianna, Falvo, Sara, Errico, Francesco, Santillo, Alessandra, Nuzzo, Tommaso, Chieffi Baccari, Gabriella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698810/ https://www.ncbi.nlm.nih.gov/pubmed/33218144 http://dx.doi.org/10.3390/ijms21228718

Ejemplares similares

D-Aspartate Depletion Perturbs Steroidogenesis and Spermatogenesis in Mice
por: Santillo, Alessandra, et al.
Publicado: (2023)

Molecular Mechanisms Elicited by d-Aspartate in Leydig Cells and Spermatogonia
por: Di Fiore, Maria Maddalena, et al.
Publicado: (2016)

D-Aspartic Acid in Vertebrate Reproduction: Animal Models and Experimental Designs ‡
por: Di Fiore, Maria Maddalena, et al.
Publicado: (2019)

D-Aspartate Upregulates DAAM1 Protein Levels in the Rat Testis and Induces Its Localization in Spermatogonia Nucleus
por: Venditti, Massimo, et al.
Publicado: (2020)

The Aromatase–Estrogen System in the Testes of Non-Mammalian Vertebrates
por: Rosati, Luigi, et al.
Publicado: (2021)

Mast Cell Population and Histamine Content in Hypothyroid Rat Tissues
por: Chieffi Baccari, Gabriella, et al.
Publicado: (2022)

The Emerging Role of Altered d-Aspartate Metabolism in Schizophrenia: New Insights From Preclinical Models and Human Studies
por: Errico, Francesco, et al.
Publicado: (2018)

Proliferative and Apoptotic Pathways in the Testis of Quail Coturnix coturnix during the Seasonal Reproductive Cycle
por: Falvo, Sara, et al.
Publicado: (2021)

A short-term high-fat diet alters rat testicular activity and blood-testis barrier integrity through the SIRT1/NRF2/MAPKs signaling pathways
por: Falvo, Sara, et al.
Publicado: (2023)

Mild Exercise Rescues Steroidogenesis and Spermatogenesis in Rats Submitted to Food Withdrawal
por: Santillo, Alessandra, et al.
Publicado: (2020)

Male Germ Cell Telomeres and Chemical Pollutants
por: Chieffi Baccari, Gabriella, et al.
Publicado: (2023)

Recovering Cucurbita pepo cv. ‘Lungo Fiorentino’ Wastes: UHPLC-HRMS/MS Metabolic Profile, the Basis for Establishing Their Nutra- and Cosmeceutical Valorisation
por: Piccolella, Simona, et al.
Publicado: (2019)

Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients
por: Nuzzo, Tommaso, et al.
Publicado: (2017)

D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans
por: Lombardo, Barbara, et al.
Publicado: (2022)

Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity
por: Sacchi, Silvia, et al.
Publicado: (2017)

Quantitative determination of free D-Asp, L-Asp and N-methyl-D-aspartate in mouse brain tissues by chiral separation and Multiple Reaction Monitoring tandem mass spectrometry
por: Fontanarosa, Carolina, et al.
Publicado: (2017)

Abnormal RasGRP1 Expression in the Post-Mortem Brain and Blood Serum of Schizophrenia Patients
por: De Rosa, Arianna, et al.
Publicado: (2022)

Machine Learning algorithm unveils glutamatergic alterations in the post-mortem schizophrenia brain
por: De Rosa, Arianna, et al.
Publicado: (2022)

D-Aspartate Modulates Nociceptive-Specific Neuron Activity and Pain Threshold in Inflammatory and Neuropathic Pain Condition in Mice
por: Boccella, Serena, et al.
Publicado: (2015)

Analysis of mRNA and Protein Levels of CAP2, DLG1 and ADAM10 Genes in Post-Mortem Brain of Schizophrenia, Parkinson’s and Alzheimer’s Disease Patients
por: Di Maio, Anna, et al.
Publicado: (2022)

Tracking the evolution of epialleles during neural differentiation and brain development: D-Aspartate oxidase as a model gene
por: Florio, Ermanno, et al.
Publicado: (2016)

DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia
por: Keller, Simona, et al.
Publicado: (2018)

A role for D-aspartate oxidase in schizophrenia and in schizophrenia-related symptoms induced by phencyclidine in mice
por: Errico, F, et al.
Publicado: (2015)

Physiology of the Endocrine Glands
por: Goodall, Alexander
Publicado: (1926)

Free D-aspartate regulates neuronal dendritic morphology, synaptic plasticity, gray matter volume and brain activity in mammals
por: Errico, F, et al.
Publicado: (2014)

Selective demethylation of two CpG sites causes postnatal activation of the Dao gene and consequent removal of d-serine within the mouse cerebellum
por: Cuomo, Mariella, et al.
Publicado: (2019)

Serum levels of N-acetyl-aspartate in migraine and tension-type headache
por: de Tommaso, Marina, et al.
Publicado: (2012)

A central role for aspartate in Mycobacterium tuberculosis physiology and virulence
por: Gouzy, Alexandre, et al.
Publicado: (2013)

The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses
por: Napolitano, Francesco, et al.
Publicado: (2019)

The Physiologic Effects of Pain on the Endocrine System
por: Tennant, Forest
Publicado: (2013)

Nusinersen mitigates neuroinflammation in severe spinal muscular atrophy patients
por: Nuzzo, Tommaso, et al.
Publicado: (2023)

Endocrine sensitivity of estrogen receptor‐positive breast cancer is negatively correlated with aspartate‐β‐hydroxylase expression
por: Shimoda, Masafumi, et al.
Publicado: (2017)

Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer
por: Bacci, Marina, et al.
Publicado: (2019)

Diabetic Encephalopathy in a Preclinical Experimental Model of Type 1 Diabetes Mellitus: Observations in Adult Female Rat
por: Falvo, Eva, et al.
Publicado: (2023)

Nusinersen Induces Disease-Severity-Specific Neurometabolic Effects in Spinal Muscular Atrophy
por: Errico, Francesco, et al.
Publicado: (2022)

Endocrine FGFs: Evolution, Physiology, Pathophysiology, and Pharmacotherapy
por: Itoh, Nobuyuki, et al.
Publicado: (2015)

Editorial: Mitochondrial Dynamics in Endocrine Physiology and Disease
por: Poderoso, Cecilia, et al.
Publicado: (2022)

Editorial: Redox and Nitrosative Signaling in Cardiovascular System: From Physiological Response to Disease
por: Santillo, Mariarosaria, et al.
Publicado: (2018)

SMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy
por: Valsecchi, Valeria, et al.
Publicado: (2023)

RasGRP1 is a causal factor in the development of l-DOPA–induced dyskinesia in Parkinson’s disease
por: Eshraghi, Mehdi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_tr2anlikebbinj7j79lvp5h9mo