Cargando…

Transferrin-Conjugated pH-Responsive γ-Cyclodextrin Nanoparticles for Antitumoral Topotecan Delivery

In this study, we developed γ-cyclodextrin-based multifunctional nanoparticles (NPs) for tumor-targeted therapy. The NPs were self-assembled using a γ-cyclodextrin (γCD) coupled with phenylacetic acid (PA), 2,3-dimethylmaleic anhydride (DMA), poly(ethylene glycol) (PEG), and transferrin (Tf), termed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yoon, Seonyoung, Kim, Yoonyoung, Youn, Yu Seok, Oh, Kyung Taek, Kim, Dongin, Lee, Eun Seong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698888/ https://www.ncbi.nlm.nih.gov/pubmed/33218116 http://dx.doi.org/10.3390/pharmaceutics12111109

Ejemplares similares

Transferrin-Conjugated Polymeric Nanoparticle for Receptor-Mediated Delivery of Doxorubicin in Doxorubicin-Resistant Breast Cancer Cells
por: Soe, Zar Chi, et al.
Publicado: (2019)

Alendronate/cRGD-Decorated Ultrafine Hyaluronate Dot Targeting Bone Metastasis
por: Lee, Eunsol, et al.
Publicado: (2020)

Transferrin Conjugated pH- and Redox-Responsive Poly(Amidoamine) Dendrimer Conjugate as an Efficient Drug Delivery Carrier for Cancer Therapy
por: Hu, Qing, et al.
Publicado: (2020)

Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan.
por: Vukovic, V., et al.
Publicado: (1997)

Endosomal pH-Responsive Fe-Based Hyaluronate Nanoparticles for Doxorubicin Delivery
por: Bae, Yangmun, et al.
Publicado: (2021)

The Lipophilic Purine Nucleoside—Tdp1 Inhibitor—Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo
por: Chernyshova, Irina A., et al.
Publicado: (2022)

Lactone Stabilized by Crosslinked Cyclodextrin Metal-Organic Frameworks to Improve Local Bioavailability of Topotecan in Lung Cancer
por: Xiong, Ting, et al.
Publicado: (2022)

Development of pH-Responsive Hyaluronic Acid-Conjugated Cyclodextrin Nanoparticles for Chemo-/CO-Gas Dual Therapy
por: Lee, Eunsol, et al.
Publicado: (2023)

Tumor-Homing pH-Sensitive Extracellular Vesicles for Targeting Heterogeneous Tumors
por: Park, Jaeduk, et al.
Publicado: (2020)

Hyaluronan-Cyclodextrin Conjugates as Doxorubicin Delivery Systems
por: Bognanni, Noemi, et al.
Publicado: (2023)

Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response
por: Kim, Oh Youn, et al.
Publicado: (2017)

2-Hydroxychalcone−β-Cyclodextrin Conjugate with pH-Modulated Photoresponsive Binding Properties
por: Paulino, Micael, et al.
Publicado: (2022)

Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan
por: Munkuev, Aldar A., et al.
Publicado: (2022)

Cyclic RGD-conjugated Pluronic(®) blending system for active, targeted drug delivery
por: Lim, Chaemin, et al.
Publicado: (2018)

Fluorescence Modulation of Conjugated Polymer Nanoparticles Embedded in Poly(N-Isopropylacrylamide) Hydrogel
por: Namgung, Ho, et al.
Publicado: (2021)

Transferrin-Conjugated PLGA Nanoparticles for Co-Delivery of Temozolomide and Bortezomib to Glioblastoma Cells
por: Ramalho, Maria João, et al.
Publicado: (2023)

Phase II Study to Topotecan and Cisplatin in Advanced Hepatocellular Carcinoma
por: Lee, Ga Young, et al.
Publicado: (2003)

Folic acid-conjugated mesoporous silica nanoparticles for enhanced therapeutic efficacy of topotecan in retina cancers
por: Qu, Wei, et al.
Publicado: (2018)

Andrographolide potentiates the antitumor effect of topotecan in acute myeloid leukemia cells through an intrinsic apoptotic pathway
por: Hodroj, Mohammad Hassan, et al.
Publicado: (2018)

Robust Inclusion Complex of Topotecan Comprised within a Rhodamine-Labeled β-Cyclodextrin: Competing Proton and Energy Transfer Processes
por: Di Nunzio, Maria Rosaria, et al.
Publicado: (2023)

Commentary: Periocular topotecan for retinoblastoma
por: Sharma, Minal, et al.
Publicado: (2018)

Development of a robust pH-sensitive polyelectrolyte ionomer complex for anticancer nanocarriers
por: Lim, Chaemin, et al.
Publicado: (2016)

Metronomic Chemotherapy Based on Topotecan or Topotecan and Cyclophosphamide Combination (CyTo) in Advanced, Pretreated Ovarian Cancer
por: Wysocki, Piotr J., et al.
Publicado: (2023)

Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan
por: Rosa-Teijeiro, Chloé, et al.
Publicado: (2021)

The Antitumor Effect of Topotecan Loaded Thiolated Chitosan-Dextran Nanoparticles for Intravitreal Chemotherapy: A Xenograft Retinoblastoma Model
por: Delrish, Elham, et al.
Publicado: (2023)

Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery
por: Taich, Paula, et al.
Publicado: (2016)

Antitumor Activity of the Carboplatin-α-Cyclodextrin Adduct
por: Liu, Weiping, et al.
Publicado: (1997)

Novel β-cyclodextrin–eosin conjugates
por: Benkovics, Gábor, et al.
Publicado: (2017)

Preparation of Doxorubicin-Loaded Carboxymethyl-β-Cyclodextrin/Chitosan Nanoparticles with Antioxidant, Antitumor Activities and pH-Sensitive Release
por: Mi, Yingqi, et al.
Publicado: (2022)

Topotecan and Cyclophosphamide in Adults with Relapsed Sarcoma
por: Blanchette, P., et al.
Publicado: (2012)

Periocular topotecan for vitreous seeds in retinoblastoma
por: Sthapit, Purnima R, et al.
Publicado: (2018)

A Polyethylenimine-Containing and Transferrin-Conjugated Lipid Nanoparticle System for Antisense Oligonucleotide Delivery to AML
por: Yuan, Yiming, et al.
Publicado: (2016)

Carbohydrate-Deficient Transferrin as a Biomarker for Screening At-Risk Drinking in Elderly Men
por: Youn, Kwangmi, et al.
Publicado: (2017)

An On-Demand pH-Sensitive Nanocluster for Cancer Treatment by Combining Photothermal Therapy and Chemotherapy
por: Sim, Taehoon, et al.
Publicado: (2020)

Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience
por: Upadhyayula, Pavan S., et al.
Publicado: (2020)

Nanoplatform for the Delivery of Topotecan in the Cancer Milieu: An Appraisal of its Therapeutic Efficacy
por: Alshammari, Mohammed Kanan, et al.
Publicado: (2022)

Photoreactive-proton-generating hyaluronidase/albumin nanoparticles-loaded PEG-hydrogel enhances antitumor efficacy and disruption of the hyaluronic acid extracellular matrix in AsPC-1 tumors
por: Lee, Woo Tak, et al.
Publicado: (2021)

Transferrin-Modified Nanoparticles for Photodynamic Therapy Enhance the Antitumor Efficacy of Hypocrellin A
por: Lin, Xi, et al.
Publicado: (2017)

Intracellular Metabolism and Cytotoxicity of Transferrin‐Neocarzinostatin Conjugates of Differing Molar Ratios
por: Sasaki, Katsunori, et al.
Publicado: (1993)

Doxorubicin-transferrin conjugate selectively overcomes multidrug resistance in leukaemia cells
por: Łubgan, Dorota, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_9p1a5iiroirn3rcm7el1ourbtu