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Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease
The aim of this systematic review and meta-analysis was to assess the blood concentrations of the total and reduced forms of the low-molecular-weight antioxidant thiol glutathione (GSH) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. A literature search...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698942/ https://www.ncbi.nlm.nih.gov/pubmed/33218130 http://dx.doi.org/10.3390/antiox9111146 |
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author | Sotgia, Salvatore Paliogiannis, Panagiotis Sotgiu, Elisabetta Mellino, Sabrina Zinellu, Elisabetta Fois, Alessandro G. Pirina, Pietro Carru, Ciriaco Mangoni, Arduino A. Zinellu, Angelo |
author_facet | Sotgia, Salvatore Paliogiannis, Panagiotis Sotgiu, Elisabetta Mellino, Sabrina Zinellu, Elisabetta Fois, Alessandro G. Pirina, Pietro Carru, Ciriaco Mangoni, Arduino A. Zinellu, Angelo |
author_sort | Sotgia, Salvatore |
collection | PubMed |
description | The aim of this systematic review and meta-analysis was to assess the blood concentrations of the total and reduced forms of the low-molecular-weight antioxidant thiol glutathione (GSH) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. A literature search was conducted in the PubMed and Web of Science databases from inception until June 2020. In the 18 studies identified (involving a total of 974 COPD patients and 631 healthy controls), the pooled reduced GSH concentrations were significantly lower in patients with COPD than controls (SMD = −3.04, 95% CI = −4.42 to −1.67; p < 0.001). By contrast, the pooled total GSH concentrations were significantly higher in patients with COPD than controls (SMD = 0.42, 95% CI = 0.11 to 0.73; p = 0.009). Our meta-analysis showed that the blood concentrations of reduced GSH, even in the presence of higher total GSH concentrations, were significantly lower in patients with COPD when compared to healthy controls. This suggests that an impaired antioxidant defense system plays an important role in the pathogenesis of COPD. |
format | Online Article Text |
id | pubmed-7698942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76989422020-11-29 Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease Sotgia, Salvatore Paliogiannis, Panagiotis Sotgiu, Elisabetta Mellino, Sabrina Zinellu, Elisabetta Fois, Alessandro G. Pirina, Pietro Carru, Ciriaco Mangoni, Arduino A. Zinellu, Angelo Antioxidants (Basel) Review The aim of this systematic review and meta-analysis was to assess the blood concentrations of the total and reduced forms of the low-molecular-weight antioxidant thiol glutathione (GSH) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. A literature search was conducted in the PubMed and Web of Science databases from inception until June 2020. In the 18 studies identified (involving a total of 974 COPD patients and 631 healthy controls), the pooled reduced GSH concentrations were significantly lower in patients with COPD than controls (SMD = −3.04, 95% CI = −4.42 to −1.67; p < 0.001). By contrast, the pooled total GSH concentrations were significantly higher in patients with COPD than controls (SMD = 0.42, 95% CI = 0.11 to 0.73; p = 0.009). Our meta-analysis showed that the blood concentrations of reduced GSH, even in the presence of higher total GSH concentrations, were significantly lower in patients with COPD when compared to healthy controls. This suggests that an impaired antioxidant defense system plays an important role in the pathogenesis of COPD. MDPI 2020-11-18 /pmc/articles/PMC7698942/ /pubmed/33218130 http://dx.doi.org/10.3390/antiox9111146 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sotgia, Salvatore Paliogiannis, Panagiotis Sotgiu, Elisabetta Mellino, Sabrina Zinellu, Elisabetta Fois, Alessandro G. Pirina, Pietro Carru, Ciriaco Mangoni, Arduino A. Zinellu, Angelo Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease |
title | Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease |
title_full | Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease |
title_fullStr | Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease |
title_full_unstemmed | Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease |
title_short | Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease |
title_sort | systematic review and meta-analysis of the blood glutathione redox state in chronic obstructive pulmonary disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698942/ https://www.ncbi.nlm.nih.gov/pubmed/33218130 http://dx.doi.org/10.3390/antiox9111146 |
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