Cargando…

Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease

The aim of this systematic review and meta-analysis was to assess the blood concentrations of the total and reduced forms of the low-molecular-weight antioxidant thiol glutathione (GSH) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. A literature search...

Descripción completa

Detalles Bibliográficos
Autores principales: Sotgia, Salvatore, Paliogiannis, Panagiotis, Sotgiu, Elisabetta, Mellino, Sabrina, Zinellu, Elisabetta, Fois, Alessandro G., Pirina, Pietro, Carru, Ciriaco, Mangoni, Arduino A., Zinellu, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698942/
https://www.ncbi.nlm.nih.gov/pubmed/33218130
http://dx.doi.org/10.3390/antiox9111146
_version_ 1783615941601394688
author Sotgia, Salvatore
Paliogiannis, Panagiotis
Sotgiu, Elisabetta
Mellino, Sabrina
Zinellu, Elisabetta
Fois, Alessandro G.
Pirina, Pietro
Carru, Ciriaco
Mangoni, Arduino A.
Zinellu, Angelo
author_facet Sotgia, Salvatore
Paliogiannis, Panagiotis
Sotgiu, Elisabetta
Mellino, Sabrina
Zinellu, Elisabetta
Fois, Alessandro G.
Pirina, Pietro
Carru, Ciriaco
Mangoni, Arduino A.
Zinellu, Angelo
author_sort Sotgia, Salvatore
collection PubMed
description The aim of this systematic review and meta-analysis was to assess the blood concentrations of the total and reduced forms of the low-molecular-weight antioxidant thiol glutathione (GSH) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. A literature search was conducted in the PubMed and Web of Science databases from inception until June 2020. In the 18 studies identified (involving a total of 974 COPD patients and 631 healthy controls), the pooled reduced GSH concentrations were significantly lower in patients with COPD than controls (SMD  =  −3.04, 95% CI = −4.42 to −1.67; p  <  0.001). By contrast, the pooled total GSH concentrations were significantly higher in patients with COPD than controls (SMD = 0.42, 95% CI = 0.11 to 0.73; p = 0.009). Our meta-analysis showed that the blood concentrations of reduced GSH, even in the presence of higher total GSH concentrations, were significantly lower in patients with COPD when compared to healthy controls. This suggests that an impaired antioxidant defense system plays an important role in the pathogenesis of COPD.
format Online
Article
Text
id pubmed-7698942
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-76989422020-11-29 Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease Sotgia, Salvatore Paliogiannis, Panagiotis Sotgiu, Elisabetta Mellino, Sabrina Zinellu, Elisabetta Fois, Alessandro G. Pirina, Pietro Carru, Ciriaco Mangoni, Arduino A. Zinellu, Angelo Antioxidants (Basel) Review The aim of this systematic review and meta-analysis was to assess the blood concentrations of the total and reduced forms of the low-molecular-weight antioxidant thiol glutathione (GSH) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. A literature search was conducted in the PubMed and Web of Science databases from inception until June 2020. In the 18 studies identified (involving a total of 974 COPD patients and 631 healthy controls), the pooled reduced GSH concentrations were significantly lower in patients with COPD than controls (SMD  =  −3.04, 95% CI = −4.42 to −1.67; p  <  0.001). By contrast, the pooled total GSH concentrations were significantly higher in patients with COPD than controls (SMD = 0.42, 95% CI = 0.11 to 0.73; p = 0.009). Our meta-analysis showed that the blood concentrations of reduced GSH, even in the presence of higher total GSH concentrations, were significantly lower in patients with COPD when compared to healthy controls. This suggests that an impaired antioxidant defense system plays an important role in the pathogenesis of COPD. MDPI 2020-11-18 /pmc/articles/PMC7698942/ /pubmed/33218130 http://dx.doi.org/10.3390/antiox9111146 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sotgia, Salvatore
Paliogiannis, Panagiotis
Sotgiu, Elisabetta
Mellino, Sabrina
Zinellu, Elisabetta
Fois, Alessandro G.
Pirina, Pietro
Carru, Ciriaco
Mangoni, Arduino A.
Zinellu, Angelo
Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease
title Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease
title_full Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease
title_fullStr Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease
title_full_unstemmed Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease
title_short Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease
title_sort systematic review and meta-analysis of the blood glutathione redox state in chronic obstructive pulmonary disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698942/
https://www.ncbi.nlm.nih.gov/pubmed/33218130
http://dx.doi.org/10.3390/antiox9111146
work_keys_str_mv AT sotgiasalvatore systematicreviewandmetaanalysisofthebloodglutathioneredoxstateinchronicobstructivepulmonarydisease
AT paliogiannispanagiotis systematicreviewandmetaanalysisofthebloodglutathioneredoxstateinchronicobstructivepulmonarydisease
AT sotgiuelisabetta systematicreviewandmetaanalysisofthebloodglutathioneredoxstateinchronicobstructivepulmonarydisease
AT mellinosabrina systematicreviewandmetaanalysisofthebloodglutathioneredoxstateinchronicobstructivepulmonarydisease
AT zinelluelisabetta systematicreviewandmetaanalysisofthebloodglutathioneredoxstateinchronicobstructivepulmonarydisease
AT foisalessandrog systematicreviewandmetaanalysisofthebloodglutathioneredoxstateinchronicobstructivepulmonarydisease
AT pirinapietro systematicreviewandmetaanalysisofthebloodglutathioneredoxstateinchronicobstructivepulmonarydisease
AT carruciriaco systematicreviewandmetaanalysisofthebloodglutathioneredoxstateinchronicobstructivepulmonarydisease
AT mangoniarduinoa systematicreviewandmetaanalysisofthebloodglutathioneredoxstateinchronicobstructivepulmonarydisease
AT zinelluangelo systematicreviewandmetaanalysisofthebloodglutathioneredoxstateinchronicobstructivepulmonarydisease