TOX is a critical regulator of tumour-specific T cell differentiation

Tumour-specific CD8 T cell dysfunction is a differentiation state that is distinct from the functional effector or memory T cell states(1–6). Here we identify the nuclear factor TOX as a crucial regulator of the differentiation of tumour-specific T (TST) cells. We show that TOX is highly expressed i...

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Detalles Bibliográficos
Autores principales: Scott, Andrew C., Dündar, Friederike, Zumbo, Paul, Chandran, Smita S., Klebanoff, Christopher A., Shakiba, Mojdeh, Trivedi, Prerak, Menocal, Laura, Appleby, Heather, Camara, Steven, Zamarin, Dmitriy, Walther, tyler, Snyder, Alexandra, Femia, Matthew R., Comen, Elizabeth A., Wen, Hannah Y., Hellmann, Matthew D., Anandasabapathy, Niroshana, Liu, Yong, Altorki, Nasser K., Lauer, Peter, Levy, Olivier, Glickman, Michael S., Kaye, Jonathan, Betel, Doron, Philip, Mary, Schietinger, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698992/
https://www.ncbi.nlm.nih.gov/pubmed/31207604
http://dx.doi.org/10.1038/s41586-019-1324-y

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