Efficient Suppression of Abdominal Aortic Aneurysm Expansion in Rats through Systemic Administration of Statin-Loaded Nanomedicine

Abdominal aortic aneurysm (AAA) is a life-threatening disease. However, no systemically injectable drug has been approved for AAA treatment due to low bioavailability. Polymeric micelles are nanomedicines that have the potential to improve therapeutic efficacy by selectively delivering drugs into di...

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Autores principales: Fukuhara, Natsumi, Honda, Yuto, Ukita, Nao, Matsui, Makoto, Miura, Yutaka, Hoshina, Katsuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699030/
https://www.ncbi.nlm.nih.gov/pubmed/33218045
http://dx.doi.org/10.3390/ijms21228702
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author Fukuhara, Natsumi
Honda, Yuto
Ukita, Nao
Matsui, Makoto
Miura, Yutaka
Hoshina, Katsuyuki
author_facet Fukuhara, Natsumi
Honda, Yuto
Ukita, Nao
Matsui, Makoto
Miura, Yutaka
Hoshina, Katsuyuki
author_sort Fukuhara, Natsumi
collection PubMed
description Abdominal aortic aneurysm (AAA) is a life-threatening disease. However, no systemically injectable drug has been approved for AAA treatment due to low bioavailability. Polymeric micelles are nanomedicines that have the potential to improve therapeutic efficacy by selectively delivering drugs into disease sites, and research has mainly focused on cancer treatments. Here, we developed a statin-loaded polymeric micelle to treat AAAs in rat models. The micelle showed medicinal efficacy by preventing aortic aneurysm expansion in a dose-dependent manner. Furthermore, the micelle-injected group showed decreased macrophage infiltration and decreased matrix metalloproteinase-9 activity in cases of AAA.
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spelling pubmed-76990302020-11-29 Efficient Suppression of Abdominal Aortic Aneurysm Expansion in Rats through Systemic Administration of Statin-Loaded Nanomedicine Fukuhara, Natsumi Honda, Yuto Ukita, Nao Matsui, Makoto Miura, Yutaka Hoshina, Katsuyuki Int J Mol Sci Article Abdominal aortic aneurysm (AAA) is a life-threatening disease. However, no systemically injectable drug has been approved for AAA treatment due to low bioavailability. Polymeric micelles are nanomedicines that have the potential to improve therapeutic efficacy by selectively delivering drugs into disease sites, and research has mainly focused on cancer treatments. Here, we developed a statin-loaded polymeric micelle to treat AAAs in rat models. The micelle showed medicinal efficacy by preventing aortic aneurysm expansion in a dose-dependent manner. Furthermore, the micelle-injected group showed decreased macrophage infiltration and decreased matrix metalloproteinase-9 activity in cases of AAA. MDPI 2020-11-18 /pmc/articles/PMC7699030/ /pubmed/33218045 http://dx.doi.org/10.3390/ijms21228702 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fukuhara, Natsumi
Honda, Yuto
Ukita, Nao
Matsui, Makoto
Miura, Yutaka
Hoshina, Katsuyuki
Efficient Suppression of Abdominal Aortic Aneurysm Expansion in Rats through Systemic Administration of Statin-Loaded Nanomedicine
title Efficient Suppression of Abdominal Aortic Aneurysm Expansion in Rats through Systemic Administration of Statin-Loaded Nanomedicine
title_full Efficient Suppression of Abdominal Aortic Aneurysm Expansion in Rats through Systemic Administration of Statin-Loaded Nanomedicine
title_fullStr Efficient Suppression of Abdominal Aortic Aneurysm Expansion in Rats through Systemic Administration of Statin-Loaded Nanomedicine
title_full_unstemmed Efficient Suppression of Abdominal Aortic Aneurysm Expansion in Rats through Systemic Administration of Statin-Loaded Nanomedicine
title_short Efficient Suppression of Abdominal Aortic Aneurysm Expansion in Rats through Systemic Administration of Statin-Loaded Nanomedicine
title_sort efficient suppression of abdominal aortic aneurysm expansion in rats through systemic administration of statin-loaded nanomedicine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699030/
https://www.ncbi.nlm.nih.gov/pubmed/33218045
http://dx.doi.org/10.3390/ijms21228702
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