GEN-09 Pursuing the function of microRNA targeting (Pro)renin receptor against glioma

(Pro)renin receptor((P)RR) is a part of the Wnt receptor complex. Wnt/β-catenin signaling pathway (Wnt signaling) plays important role in pathogenesis and self-renewal of glioblastoma (GBM), or differentiation of glioma stem cell. We previously reported that (P)RR activated Wnt signaling, (P)RR expr...

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Detalles Bibliográficos
Autores principales: Ogawa, Daisuke, Fujimori, Takeshi, Toyota, Yasunori, Hatakeyama, Tetsuhiro, Okauchi, Masanobu, Kawanishi, Masahiko, Miyake, Keisuke, Masaki, Tsutomu, Nishiyama, Akira, Tamiya, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699105/
http://dx.doi.org/10.1093/noajnl/vdaa143.021
Descripción
Sumario:(Pro)renin receptor((P)RR) is a part of the Wnt receptor complex. Wnt/β-catenin signaling pathway (Wnt signaling) plays important role in pathogenesis and self-renewal of glioblastoma (GBM), or differentiation of glioma stem cell. We previously reported that (P)RR activated Wnt signaling, (P)RR expression correlated with malignancy of glioma, and treatment with (P)RR siRNA reduced the proliferative capacity. This time, we have searched for over 2632 microRNAs by microRNA microarray that its expression is affected by (P)RR whether overexpressed or suppressed and examined their effects in GBM cell lines or its glioma stem cells.

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