GEN-09 Pursuing the function of microRNA targeting (Pro)renin receptor against glioma

(Pro)renin receptor((P)RR) is a part of the Wnt receptor complex. Wnt/β-catenin signaling pathway (Wnt signaling) plays important role in pathogenesis and self-renewal of glioblastoma (GBM), or differentiation of glioma stem cell. We previously reported that (P)RR activated Wnt signaling, (P)RR expr...

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Autores principales: Ogawa, Daisuke, Fujimori, Takeshi, Toyota, Yasunori, Hatakeyama, Tetsuhiro, Okauchi, Masanobu, Kawanishi, Masahiko, Miyake, Keisuke, Masaki, Tsutomu, Nishiyama, Akira, Tamiya, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699105/
http://dx.doi.org/10.1093/noajnl/vdaa143.021
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author Ogawa, Daisuke
Fujimori, Takeshi
Toyota, Yasunori
Hatakeyama, Tetsuhiro
Okauchi, Masanobu
Kawanishi, Masahiko
Miyake, Keisuke
Masaki, Tsutomu
Nishiyama, Akira
Tamiya, Takashi
author_facet Ogawa, Daisuke
Fujimori, Takeshi
Toyota, Yasunori
Hatakeyama, Tetsuhiro
Okauchi, Masanobu
Kawanishi, Masahiko
Miyake, Keisuke
Masaki, Tsutomu
Nishiyama, Akira
Tamiya, Takashi
author_sort Ogawa, Daisuke
collection PubMed
description (Pro)renin receptor((P)RR) is a part of the Wnt receptor complex. Wnt/β-catenin signaling pathway (Wnt signaling) plays important role in pathogenesis and self-renewal of glioblastoma (GBM), or differentiation of glioma stem cell. We previously reported that (P)RR activated Wnt signaling, (P)RR expression correlated with malignancy of glioma, and treatment with (P)RR siRNA reduced the proliferative capacity. This time, we have searched for over 2632 microRNAs by microRNA microarray that its expression is affected by (P)RR whether overexpressed or suppressed and examined their effects in GBM cell lines or its glioma stem cells.
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spelling pubmed-76991052020-12-02 GEN-09 Pursuing the function of microRNA targeting (Pro)renin receptor against glioma Ogawa, Daisuke Fujimori, Takeshi Toyota, Yasunori Hatakeyama, Tetsuhiro Okauchi, Masanobu Kawanishi, Masahiko Miyake, Keisuke Masaki, Tsutomu Nishiyama, Akira Tamiya, Takashi Neurooncol Adv Supplement Abstracts (Pro)renin receptor((P)RR) is a part of the Wnt receptor complex. Wnt/β-catenin signaling pathway (Wnt signaling) plays important role in pathogenesis and self-renewal of glioblastoma (GBM), or differentiation of glioma stem cell. We previously reported that (P)RR activated Wnt signaling, (P)RR expression correlated with malignancy of glioma, and treatment with (P)RR siRNA reduced the proliferative capacity. This time, we have searched for over 2632 microRNAs by microRNA microarray that its expression is affected by (P)RR whether overexpressed or suppressed and examined their effects in GBM cell lines or its glioma stem cells. Oxford University Press 2020-11-28 /pmc/articles/PMC7699105/ http://dx.doi.org/10.1093/noajnl/vdaa143.021 Text en © The Author(s) 2020. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Supplement Abstracts
Ogawa, Daisuke
Fujimori, Takeshi
Toyota, Yasunori
Hatakeyama, Tetsuhiro
Okauchi, Masanobu
Kawanishi, Masahiko
Miyake, Keisuke
Masaki, Tsutomu
Nishiyama, Akira
Tamiya, Takashi
GEN-09 Pursuing the function of microRNA targeting (Pro)renin receptor against glioma
title GEN-09 Pursuing the function of microRNA targeting (Pro)renin receptor against glioma
title_full GEN-09 Pursuing the function of microRNA targeting (Pro)renin receptor against glioma
title_fullStr GEN-09 Pursuing the function of microRNA targeting (Pro)renin receptor against glioma
title_full_unstemmed GEN-09 Pursuing the function of microRNA targeting (Pro)renin receptor against glioma
title_short GEN-09 Pursuing the function of microRNA targeting (Pro)renin receptor against glioma
title_sort gen-09 pursuing the function of microrna targeting (pro)renin receptor against glioma
topic Supplement Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699105/
http://dx.doi.org/10.1093/noajnl/vdaa143.021
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