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Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity
The recognition of ACE2 by the receptor-binding domain (RBD) of spike protein mediates host cell entry. The objective of the work is to identify SARS-CoV2 spike variants that emerged during the pandemic and evaluate their binding affinity with ACE2. Evolutionary analysis of 2178 SARS-CoV2 genomes id...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier Inc.
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699163/ https://www.ncbi.nlm.nih.gov/pubmed/33272568 http://dx.doi.org/10.1016/j.bbrc.2020.11.075 |