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E3 Ubiquitin Ligase APC/C(Cdh1) Negatively Regulates FAH Protein Stability by Promoting Its Polyubiquitination

Fumarylacetoacetate hydrolase (FAH) is the last enzyme in the degradation pathway of the amino acids tyrosine and phenylalanine in mammals that catalyzes the hydrolysis of 4-fumarylacetoacetate into acetoacetate and fumarate. Mutations of the FAH gene are associated with hereditary tyrosinemia type...

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Detalles Bibliográficos
Autores principales:	Kaushal, Kamini, Woo, Sang Hyeon, Tyagi, Apoorvi, Kim, Dong Ha, Suresh, Bharathi, Kim, Kye-Seong, Ramakrishna, Suresh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699203/ https://www.ncbi.nlm.nih.gov/pubmed/33218190 http://dx.doi.org/10.3390/ijms21228719

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