Cargando…

Role of iRhoms 1 and 2 in Endochondral Ossification

Growth of the axial and appendicular skeleton depends on endochondral ossification, which is controlled by tightly regulated cell–cell interactions in the developing growth plates. Previous studies have uncovered an important role of a disintegrin and metalloprotease 17 (ADAM17) in the normal develo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fang, Renpeng, Haxaire, Coline, Otero, Miguel, Lessard, Samantha, Weskamp, Gisela, McIlwain, David R., Mak, Tak W., Lichtenthaler, Stefan F., Blobel, Carl P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699240/ https://www.ncbi.nlm.nih.gov/pubmed/33227998 http://dx.doi.org/10.3390/ijms21228732

Ejemplares similares

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
por: Oikonomidi, Ioanna, et al.
Publicado: (2018)

Association of iRhom1 and iRhom2 expression with prognosis in patients with cervical cancer and possible signaling pathways
por: Xu, Qin, et al.
Publicado: (2020)

iRhoms; Its Functions and Essential Roles
por: Lee, Min-Young, et al.
Publicado: (2016)

The molecular, cellular and pathophysiological roles of iRhom pseudoproteases
por: Dulloo, Iqbal, et al.
Publicado: (2019)

iRhom2: An Emerging Adaptor Regulating Immunity and Disease
por: Al-Salihi, Mazin A., et al.
Publicado: (2020)

iRhom2 in the pathogenesis of oral squamous cell carcinoma
por: Agwae, Matthew E., et al.
Publicado: (2020)

The Role of iRhom2 in Metabolic and Cardiovascular-Related Disorders
por: Geesala, Ramasatyaveni, et al.
Publicado: (2020)

Identification of Molecular Determinants in iRhoms1 and 2 That Contribute to the Substrate Selectivity of Stimulated ADAM17
por: Zhao, Yi, et al.
Publicado: (2022)

The Threshold Effect: Lipopolysaccharide-Induced Inflammatory Responses in Primary Macrophages Are Differentially Regulated in an iRhom2-Dependent Manner
por: Skurski, Joseph, et al.
Publicado: (2021)

Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis
por: Badenes, Marina, et al.
Publicado: (2019)

Differential Induction of the ADAM17 Regulators iRhom1 and 2 in Endothelial Cells
por: Babendreyer, Aaron, et al.
Publicado: (2020)

iRhom2 Mutation Leads to Aberrant Hair Follicle Differentiation in Mice
por: Leilei, Yang, et al.
Publicado: (2014)

iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral Susceptibility
por: Chao-Chu, Jennifer, et al.
Publicado: (2020)

Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice
por: Siggs, Owen M., et al.
Publicado: (2014)

Proteomic analysis of differentially expressed skin proteins in iRhom2(Uncv) mice
por: Liu, Bing, et al.
Publicado: (2015)

Role of iRhom2 in intestinal ischemia-reperfusion-mediated acute lung injury
por: Kim, Jee Hyun, et al.
Publicado: (2018)

Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution
por: Calligaris, Matteo, et al.
Publicado: (2021)

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE
por: Cavadas, Miguel, et al.
Publicado: (2017)

Inflammatory activation of surface molecule shedding by upregulation of the pseudoprotease iRhom2 in colon epithelial cells
por: Giese, Anja Adelina, et al.
Publicado: (2021)

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response
por: Arcidiacono, Paola, et al.
Publicado: (2018)

iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction
por: Barnette, Damien N., et al.
Publicado: (2018)

The iRhom2/ADAM17 Axis Attenuates Bacterial Uptake by Phagocytes in a Cell Autonomous Manner
por: Seifert, Anke, et al.
Publicado: (2020)

The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release
por: Düsterhöft, Stefan, et al.
Publicado: (2021)

iRhom1 regulates proteasome activity via PAC1/2 under ER stress
por: Lee, WonJae, et al.
Publicado: (2015)

Author Correction: Role of iRhom2 in intestinal ischemia-reperfusion-mediated acute lung injury
por: Kim, Jee Hyun, et al.
Publicado: (2018)

iRHOM2 regulates inflammation and endothelial barrier permeability via CX3CL1
por: Yan, Huiyuan, et al.
Publicado: (2023)

Hedgehog Signaling in Endochondral Ossification
por: Ohba, Shinsuke
Publicado: (2016)

A structural model of the iRhom–ADAM17 sheddase complex reveals functional insights into its trafficking and activity
por: Kahveci-Türköz, Selcan, et al.
Publicado: (2023)

iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA
por: Luo, Wei-Wei, et al.
Publicado: (2017)

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex
por: Künzel, Ulrike, et al.
Publicado: (2018)

Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling
por: Grieve, Adam Graham, et al.
Publicado: (2017)

Inactive rhomboid proteins RHBDF1 and RHBDF2 (iRhoms): a decade of research in murine models
por: Burzenski, Lisa M., et al.
Publicado: (2021)

iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells
por: Sieber, Boris, et al.
Publicado: (2022)

Transcriptional Network Controlling Endochondral Ossification
por: Hata, Kenji, et al.
Publicado: (2017)

iRhom pseudoproteases regulate ER stress-induced cell death through IP(3) receptors and BCL-2
por: Dulloo, Iqbal, et al.
Publicado: (2022)

Total flavones of Abelmoschus manihot improve diabetic nephropathy by inhibiting the iRhom2/TACE signalling pathway activity in rats
por: Liu, Su, et al.
Publicado: (2017)

4-Hydroxyisoleucine relieves inflammation through iRhom2-dependent pathway in co-cultured macrophages and adipocytes with LPS stimulation
por: Zhou, Cong, et al.
Publicado: (2020)

Deficiency in Inactive Rhomboid Protein2 (iRhom2) Alleviates Alcoholic Liver Fibrosis by Suppressing Inflammation and Oxidative Stress
por: Liu, Yangwenshu, et al.
Publicado: (2022)

Collagenous bone matrix-induced endochondral ossification hemopoiesis
Publicado: (1976)

iRhom2 loss alleviates renal injury in long-term PM2.5-exposed mice by suppression of inflammation and oxidative stress
por: Chenxu, Ge, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_958aeqfkac6c9qpiur1vr7t7p0