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The Acquisition of Multidrug-Resistant Bacteria in Patients Admitted to COVID-19 Intensive Care Units: A Monocentric Retrospective Case Control Study
Whether the risk of multidrug-resistant bacteria (MDRB) acquisition in the intensive care unit (ICU) is modified by the COVID-19 crisis is unknown. In this single center case control study, we measured the rate of MDRB acquisition in patients admitted in COVID-19 ICU and compared it with patients ad...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699265/ https://www.ncbi.nlm.nih.gov/pubmed/33227956 http://dx.doi.org/10.3390/microorganisms8111821 |
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author | Bogossian, Elisa G. Taccone, Fabio S. Izzi, Antonio Yin, Nicolas Garufi, Alessandra Hublet, Stephane Njimi, Hassane Ego, Amedee Gorham, Julie Byl, Baudouin Brasseur, Alexandre Hites, Maya Vincent, Jean-Louis Creteur, Jacques Grimaldi, David |
author_facet | Bogossian, Elisa G. Taccone, Fabio S. Izzi, Antonio Yin, Nicolas Garufi, Alessandra Hublet, Stephane Njimi, Hassane Ego, Amedee Gorham, Julie Byl, Baudouin Brasseur, Alexandre Hites, Maya Vincent, Jean-Louis Creteur, Jacques Grimaldi, David |
author_sort | Bogossian, Elisa G. |
collection | PubMed |
description | Whether the risk of multidrug-resistant bacteria (MDRB) acquisition in the intensive care unit (ICU) is modified by the COVID-19 crisis is unknown. In this single center case control study, we measured the rate of MDRB acquisition in patients admitted in COVID-19 ICU and compared it with patients admitted in the same ICU for subarachnoid hemorrhage (controls) matched 1:1 on length of ICU stay and mechanical ventilation. All patients were systematically and repeatedly screened for MDRB carriage. We compared the rate of MDRB acquisition in COVID-19 patients and in control using a competing risk analysis. Of note, although we tried to match COVID-19 patients with septic shock patients, we were unable due to the longer stay of COVID-19 patients. Among 72 patients admitted to the COVID-19 ICUs, 33% acquired 31 MDRB during ICU stay. The incidence density of MDRB acquisition was 30/1000 patient days. Antimicrobial therapy and exposure time were associated with higher rate of MDRB acquisition. Among the 72 SAH patients, 21% acquired MDRB, with an incidence density was 18/1000 patient days. The septic patients had more comorbidities and a greater number of previous hospitalizations than the COVID-19 patients. The incidence density of MDRB acquisition was 30/1000 patient days. The association between COVID-19 and MDRB acquisition (compared to control) risk did not reach statistical significance in the multivariable competing risk analysis (sHR 1.71 (CI 95% 0.93–3.21)). Thus, we conclude that, despite strong physical isolation, acquisition rate of MDRB in ICU patients was at least similar during the COVID-19 first wave compared to previous period. |
format | Online Article Text |
id | pubmed-7699265 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76992652020-11-29 The Acquisition of Multidrug-Resistant Bacteria in Patients Admitted to COVID-19 Intensive Care Units: A Monocentric Retrospective Case Control Study Bogossian, Elisa G. Taccone, Fabio S. Izzi, Antonio Yin, Nicolas Garufi, Alessandra Hublet, Stephane Njimi, Hassane Ego, Amedee Gorham, Julie Byl, Baudouin Brasseur, Alexandre Hites, Maya Vincent, Jean-Louis Creteur, Jacques Grimaldi, David Microorganisms Article Whether the risk of multidrug-resistant bacteria (MDRB) acquisition in the intensive care unit (ICU) is modified by the COVID-19 crisis is unknown. In this single center case control study, we measured the rate of MDRB acquisition in patients admitted in COVID-19 ICU and compared it with patients admitted in the same ICU for subarachnoid hemorrhage (controls) matched 1:1 on length of ICU stay and mechanical ventilation. All patients were systematically and repeatedly screened for MDRB carriage. We compared the rate of MDRB acquisition in COVID-19 patients and in control using a competing risk analysis. Of note, although we tried to match COVID-19 patients with septic shock patients, we were unable due to the longer stay of COVID-19 patients. Among 72 patients admitted to the COVID-19 ICUs, 33% acquired 31 MDRB during ICU stay. The incidence density of MDRB acquisition was 30/1000 patient days. Antimicrobial therapy and exposure time were associated with higher rate of MDRB acquisition. Among the 72 SAH patients, 21% acquired MDRB, with an incidence density was 18/1000 patient days. The septic patients had more comorbidities and a greater number of previous hospitalizations than the COVID-19 patients. The incidence density of MDRB acquisition was 30/1000 patient days. The association between COVID-19 and MDRB acquisition (compared to control) risk did not reach statistical significance in the multivariable competing risk analysis (sHR 1.71 (CI 95% 0.93–3.21)). Thus, we conclude that, despite strong physical isolation, acquisition rate of MDRB in ICU patients was at least similar during the COVID-19 first wave compared to previous period. MDPI 2020-11-19 /pmc/articles/PMC7699265/ /pubmed/33227956 http://dx.doi.org/10.3390/microorganisms8111821 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bogossian, Elisa G. Taccone, Fabio S. Izzi, Antonio Yin, Nicolas Garufi, Alessandra Hublet, Stephane Njimi, Hassane Ego, Amedee Gorham, Julie Byl, Baudouin Brasseur, Alexandre Hites, Maya Vincent, Jean-Louis Creteur, Jacques Grimaldi, David The Acquisition of Multidrug-Resistant Bacteria in Patients Admitted to COVID-19 Intensive Care Units: A Monocentric Retrospective Case Control Study |
title | The Acquisition of Multidrug-Resistant Bacteria in Patients Admitted to COVID-19 Intensive Care Units: A Monocentric Retrospective Case Control Study |
title_full | The Acquisition of Multidrug-Resistant Bacteria in Patients Admitted to COVID-19 Intensive Care Units: A Monocentric Retrospective Case Control Study |
title_fullStr | The Acquisition of Multidrug-Resistant Bacteria in Patients Admitted to COVID-19 Intensive Care Units: A Monocentric Retrospective Case Control Study |
title_full_unstemmed | The Acquisition of Multidrug-Resistant Bacteria in Patients Admitted to COVID-19 Intensive Care Units: A Monocentric Retrospective Case Control Study |
title_short | The Acquisition of Multidrug-Resistant Bacteria in Patients Admitted to COVID-19 Intensive Care Units: A Monocentric Retrospective Case Control Study |
title_sort | acquisition of multidrug-resistant bacteria in patients admitted to covid-19 intensive care units: a monocentric retrospective case control study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699265/ https://www.ncbi.nlm.nih.gov/pubmed/33227956 http://dx.doi.org/10.3390/microorganisms8111821 |
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