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Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer

Prostate cancer is among the most common malignant tumors worldwide. Matrix metalloproteinase (MMP)-11 is involved in extracellular matrix degradation and remodeling and plays an essential role in cancer development and metastasis. This study investigated the association of MMP-11 polymorphisms with...

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Autores principales: Hsieh, Chun-Yu, Chou, Ying-Erh, Lin, Chia-Yen, Wang, Shian-Shiang, Chien, Ming-Hsien, Tang, Chih-Hsin, Lin, Jian-Cheng, Wen, Yu-Ching, Yang, Shun-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699319/
https://www.ncbi.nlm.nih.gov/pubmed/33228130
http://dx.doi.org/10.3390/ijerph17228603
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author Hsieh, Chun-Yu
Chou, Ying-Erh
Lin, Chia-Yen
Wang, Shian-Shiang
Chien, Ming-Hsien
Tang, Chih-Hsin
Lin, Jian-Cheng
Wen, Yu-Ching
Yang, Shun-Fa
author_facet Hsieh, Chun-Yu
Chou, Ying-Erh
Lin, Chia-Yen
Wang, Shian-Shiang
Chien, Ming-Hsien
Tang, Chih-Hsin
Lin, Jian-Cheng
Wen, Yu-Ching
Yang, Shun-Fa
author_sort Hsieh, Chun-Yu
collection PubMed
description Prostate cancer is among the most common malignant tumors worldwide. Matrix metalloproteinase (MMP)-11 is involved in extracellular matrix degradation and remodeling and plays an essential role in cancer development and metastasis. This study investigated the association of MMP-11 polymorphisms with the clinicopathological characteristics and biochemical recurrence of prostate cancer. Five single-nucleotide polymorphisms (SNPs) of the MMP-11 were analyzed in 578 patients with prostate cancer through real-time polymerase chain reaction analysis. A prostate-specific antigen level of >10 ng/mL, Gleason grade groups 4 + 5, advanced tumor stage, lymph node metastasis, invasion, and high-risk D’Amico classification were significantly associated with biochemical recurrence in the patients (p < 0.001). MMP-11 rs131451 “TC + CC” polymorphic variants were associated with advanced clinical stage (T stage; p = 0.007) and high-risk D’Amico classification (p = 0.015) in patients with biochemical recurrence. These findings demonstrate that MMP-11 polymorphisms were not associated with prostate cancer susceptibility; however, the rs131451 polymorphic variant was associated with late-stage tumors and high-risk D’Amico classification in prostate cancer patients with biochemical recurrence. Thus, the MMP-11 SNP rs131451 may contribute to the tumor development in prostate cancer patients with biochemical recurrence.
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spelling pubmed-76993192020-11-29 Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer Hsieh, Chun-Yu Chou, Ying-Erh Lin, Chia-Yen Wang, Shian-Shiang Chien, Ming-Hsien Tang, Chih-Hsin Lin, Jian-Cheng Wen, Yu-Ching Yang, Shun-Fa Int J Environ Res Public Health Article Prostate cancer is among the most common malignant tumors worldwide. Matrix metalloproteinase (MMP)-11 is involved in extracellular matrix degradation and remodeling and plays an essential role in cancer development and metastasis. This study investigated the association of MMP-11 polymorphisms with the clinicopathological characteristics and biochemical recurrence of prostate cancer. Five single-nucleotide polymorphisms (SNPs) of the MMP-11 were analyzed in 578 patients with prostate cancer through real-time polymerase chain reaction analysis. A prostate-specific antigen level of >10 ng/mL, Gleason grade groups 4 + 5, advanced tumor stage, lymph node metastasis, invasion, and high-risk D’Amico classification were significantly associated with biochemical recurrence in the patients (p < 0.001). MMP-11 rs131451 “TC + CC” polymorphic variants were associated with advanced clinical stage (T stage; p = 0.007) and high-risk D’Amico classification (p = 0.015) in patients with biochemical recurrence. These findings demonstrate that MMP-11 polymorphisms were not associated with prostate cancer susceptibility; however, the rs131451 polymorphic variant was associated with late-stage tumors and high-risk D’Amico classification in prostate cancer patients with biochemical recurrence. Thus, the MMP-11 SNP rs131451 may contribute to the tumor development in prostate cancer patients with biochemical recurrence. MDPI 2020-11-19 2020-11 /pmc/articles/PMC7699319/ /pubmed/33228130 http://dx.doi.org/10.3390/ijerph17228603 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hsieh, Chun-Yu
Chou, Ying-Erh
Lin, Chia-Yen
Wang, Shian-Shiang
Chien, Ming-Hsien
Tang, Chih-Hsin
Lin, Jian-Cheng
Wen, Yu-Ching
Yang, Shun-Fa
Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer
title Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer
title_full Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer
title_fullStr Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer
title_full_unstemmed Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer
title_short Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer
title_sort impact of matrix metalloproteinase-11 gene polymorphisms on biochemical recurrence and clinicopathological characteristics of prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699319/
https://www.ncbi.nlm.nih.gov/pubmed/33228130
http://dx.doi.org/10.3390/ijerph17228603
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