Cargando…
Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer
Prostate cancer is among the most common malignant tumors worldwide. Matrix metalloproteinase (MMP)-11 is involved in extracellular matrix degradation and remodeling and plays an essential role in cancer development and metastasis. This study investigated the association of MMP-11 polymorphisms with...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699319/ https://www.ncbi.nlm.nih.gov/pubmed/33228130 http://dx.doi.org/10.3390/ijerph17228603 |
_version_ | 1783616021541683200 |
---|---|
author | Hsieh, Chun-Yu Chou, Ying-Erh Lin, Chia-Yen Wang, Shian-Shiang Chien, Ming-Hsien Tang, Chih-Hsin Lin, Jian-Cheng Wen, Yu-Ching Yang, Shun-Fa |
author_facet | Hsieh, Chun-Yu Chou, Ying-Erh Lin, Chia-Yen Wang, Shian-Shiang Chien, Ming-Hsien Tang, Chih-Hsin Lin, Jian-Cheng Wen, Yu-Ching Yang, Shun-Fa |
author_sort | Hsieh, Chun-Yu |
collection | PubMed |
description | Prostate cancer is among the most common malignant tumors worldwide. Matrix metalloproteinase (MMP)-11 is involved in extracellular matrix degradation and remodeling and plays an essential role in cancer development and metastasis. This study investigated the association of MMP-11 polymorphisms with the clinicopathological characteristics and biochemical recurrence of prostate cancer. Five single-nucleotide polymorphisms (SNPs) of the MMP-11 were analyzed in 578 patients with prostate cancer through real-time polymerase chain reaction analysis. A prostate-specific antigen level of >10 ng/mL, Gleason grade groups 4 + 5, advanced tumor stage, lymph node metastasis, invasion, and high-risk D’Amico classification were significantly associated with biochemical recurrence in the patients (p < 0.001). MMP-11 rs131451 “TC + CC” polymorphic variants were associated with advanced clinical stage (T stage; p = 0.007) and high-risk D’Amico classification (p = 0.015) in patients with biochemical recurrence. These findings demonstrate that MMP-11 polymorphisms were not associated with prostate cancer susceptibility; however, the rs131451 polymorphic variant was associated with late-stage tumors and high-risk D’Amico classification in prostate cancer patients with biochemical recurrence. Thus, the MMP-11 SNP rs131451 may contribute to the tumor development in prostate cancer patients with biochemical recurrence. |
format | Online Article Text |
id | pubmed-7699319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76993192020-11-29 Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer Hsieh, Chun-Yu Chou, Ying-Erh Lin, Chia-Yen Wang, Shian-Shiang Chien, Ming-Hsien Tang, Chih-Hsin Lin, Jian-Cheng Wen, Yu-Ching Yang, Shun-Fa Int J Environ Res Public Health Article Prostate cancer is among the most common malignant tumors worldwide. Matrix metalloproteinase (MMP)-11 is involved in extracellular matrix degradation and remodeling and plays an essential role in cancer development and metastasis. This study investigated the association of MMP-11 polymorphisms with the clinicopathological characteristics and biochemical recurrence of prostate cancer. Five single-nucleotide polymorphisms (SNPs) of the MMP-11 were analyzed in 578 patients with prostate cancer through real-time polymerase chain reaction analysis. A prostate-specific antigen level of >10 ng/mL, Gleason grade groups 4 + 5, advanced tumor stage, lymph node metastasis, invasion, and high-risk D’Amico classification were significantly associated with biochemical recurrence in the patients (p < 0.001). MMP-11 rs131451 “TC + CC” polymorphic variants were associated with advanced clinical stage (T stage; p = 0.007) and high-risk D’Amico classification (p = 0.015) in patients with biochemical recurrence. These findings demonstrate that MMP-11 polymorphisms were not associated with prostate cancer susceptibility; however, the rs131451 polymorphic variant was associated with late-stage tumors and high-risk D’Amico classification in prostate cancer patients with biochemical recurrence. Thus, the MMP-11 SNP rs131451 may contribute to the tumor development in prostate cancer patients with biochemical recurrence. MDPI 2020-11-19 2020-11 /pmc/articles/PMC7699319/ /pubmed/33228130 http://dx.doi.org/10.3390/ijerph17228603 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hsieh, Chun-Yu Chou, Ying-Erh Lin, Chia-Yen Wang, Shian-Shiang Chien, Ming-Hsien Tang, Chih-Hsin Lin, Jian-Cheng Wen, Yu-Ching Yang, Shun-Fa Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer |
title | Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer |
title_full | Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer |
title_fullStr | Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer |
title_full_unstemmed | Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer |
title_short | Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer |
title_sort | impact of matrix metalloproteinase-11 gene polymorphisms on biochemical recurrence and clinicopathological characteristics of prostate cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699319/ https://www.ncbi.nlm.nih.gov/pubmed/33228130 http://dx.doi.org/10.3390/ijerph17228603 |
work_keys_str_mv | AT hsiehchunyu impactofmatrixmetalloproteinase11genepolymorphismsonbiochemicalrecurrenceandclinicopathologicalcharacteristicsofprostatecancer AT chouyingerh impactofmatrixmetalloproteinase11genepolymorphismsonbiochemicalrecurrenceandclinicopathologicalcharacteristicsofprostatecancer AT linchiayen impactofmatrixmetalloproteinase11genepolymorphismsonbiochemicalrecurrenceandclinicopathologicalcharacteristicsofprostatecancer AT wangshianshiang impactofmatrixmetalloproteinase11genepolymorphismsonbiochemicalrecurrenceandclinicopathologicalcharacteristicsofprostatecancer AT chienminghsien impactofmatrixmetalloproteinase11genepolymorphismsonbiochemicalrecurrenceandclinicopathologicalcharacteristicsofprostatecancer AT tangchihhsin impactofmatrixmetalloproteinase11genepolymorphismsonbiochemicalrecurrenceandclinicopathologicalcharacteristicsofprostatecancer AT linjiancheng impactofmatrixmetalloproteinase11genepolymorphismsonbiochemicalrecurrenceandclinicopathologicalcharacteristicsofprostatecancer AT wenyuching impactofmatrixmetalloproteinase11genepolymorphismsonbiochemicalrecurrenceandclinicopathologicalcharacteristicsofprostatecancer AT yangshunfa impactofmatrixmetalloproteinase11genepolymorphismsonbiochemicalrecurrenceandclinicopathologicalcharacteristicsofprostatecancer |