SGLT2 Inhibition by Intraperitoneal Dapagliflozin Mitigates Peritoneal Fibrosis and Ultrafiltration Failure in a Mouse Model of Chronic Peritoneal Exposure to High-Glucose Dialysate

Peritoneal dialysis (PD) is limited by glucose-mediated peritoneal membrane (PM) fibrosis, angiogenesis, and ultrafiltration failure. Influencing PM integrity by pharmacologically targeting sodium-dependent glucose transporter (SGLT)-mediated glucose uptake has not been studied. In this study, wildt...

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Detalles Bibliográficos
Autores principales: Balzer, Michael S., Rong, Song, Nordlohne, Johannes, Zemtsovski, Jan D., Schmidt, Sonja, Stapel, Britta, Bartosova, Maria, von Vietinghoff, Sibylle, Haller, Hermann, Schmitt, Claus P., Shushakova, Nelli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699342/
https://www.ncbi.nlm.nih.gov/pubmed/33228017
http://dx.doi.org/10.3390/biom10111573

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