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Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality
Intra-lysosomal accumulation of the autofluorescent “residue” known as lipofuscin, which is found within postmitotic cells, remains controversial. Although it was considered a harmless hallmark of aging, its presence is detrimental as it continually accumulates. The latest evidence highlighted that...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699382/ https://www.ncbi.nlm.nih.gov/pubmed/33228124 http://dx.doi.org/10.3390/medicina56110626 |
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author | Ilie, Ovidiu-Dumitru Ciobica, Alin Riga, Sorin Dhunna, Nitasha McKenna, Jack Mavroudis, Ioannis Doroftei, Bogdan Ciobanu, Adela-Magdalena Riga, Dan |
author_facet | Ilie, Ovidiu-Dumitru Ciobica, Alin Riga, Sorin Dhunna, Nitasha McKenna, Jack Mavroudis, Ioannis Doroftei, Bogdan Ciobanu, Adela-Magdalena Riga, Dan |
author_sort | Ilie, Ovidiu-Dumitru |
collection | PubMed |
description | Intra-lysosomal accumulation of the autofluorescent “residue” known as lipofuscin, which is found within postmitotic cells, remains controversial. Although it was considered a harmless hallmark of aging, its presence is detrimental as it continually accumulates. The latest evidence highlighted that lipofuscin strongly correlates with the excessive production of reactive oxygen species; however, despite this, lipofuscin cannot be removed by the biological recycling mechanisms. The antagonistic effects exerted at the DNA level culminate in a dysregulation of the cell cycle, by inducing a loss of the entire internal environment and abnormal gene(s) expression. Additionally, it appears that a crucial role in the production of reactive oxygen species can be attributed to gut microbiota, due to their ability to shape our behavior and neurodevelopment through their maintenance of the central nervous system. |
format | Online Article Text |
id | pubmed-7699382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76993822020-11-29 Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality Ilie, Ovidiu-Dumitru Ciobica, Alin Riga, Sorin Dhunna, Nitasha McKenna, Jack Mavroudis, Ioannis Doroftei, Bogdan Ciobanu, Adela-Magdalena Riga, Dan Medicina (Kaunas) Review Intra-lysosomal accumulation of the autofluorescent “residue” known as lipofuscin, which is found within postmitotic cells, remains controversial. Although it was considered a harmless hallmark of aging, its presence is detrimental as it continually accumulates. The latest evidence highlighted that lipofuscin strongly correlates with the excessive production of reactive oxygen species; however, despite this, lipofuscin cannot be removed by the biological recycling mechanisms. The antagonistic effects exerted at the DNA level culminate in a dysregulation of the cell cycle, by inducing a loss of the entire internal environment and abnormal gene(s) expression. Additionally, it appears that a crucial role in the production of reactive oxygen species can be attributed to gut microbiota, due to their ability to shape our behavior and neurodevelopment through their maintenance of the central nervous system. MDPI 2020-11-19 /pmc/articles/PMC7699382/ /pubmed/33228124 http://dx.doi.org/10.3390/medicina56110626 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ilie, Ovidiu-Dumitru Ciobica, Alin Riga, Sorin Dhunna, Nitasha McKenna, Jack Mavroudis, Ioannis Doroftei, Bogdan Ciobanu, Adela-Magdalena Riga, Dan Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality |
title | Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality |
title_full | Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality |
title_fullStr | Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality |
title_full_unstemmed | Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality |
title_short | Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality |
title_sort | mini-review on lipofuscin and aging: focusing on the molecular interface, the biological recycling mechanism, oxidative stress, and the gut-brain axis functionality |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699382/ https://www.ncbi.nlm.nih.gov/pubmed/33228124 http://dx.doi.org/10.3390/medicina56110626 |
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