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Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality

Intra-lysosomal accumulation of the autofluorescent “residue” known as lipofuscin, which is found within postmitotic cells, remains controversial. Although it was considered a harmless hallmark of aging, its presence is detrimental as it continually accumulates. The latest evidence highlighted that...

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Autores principales: Ilie, Ovidiu-Dumitru, Ciobica, Alin, Riga, Sorin, Dhunna, Nitasha, McKenna, Jack, Mavroudis, Ioannis, Doroftei, Bogdan, Ciobanu, Adela-Magdalena, Riga, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699382/
https://www.ncbi.nlm.nih.gov/pubmed/33228124
http://dx.doi.org/10.3390/medicina56110626
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author Ilie, Ovidiu-Dumitru
Ciobica, Alin
Riga, Sorin
Dhunna, Nitasha
McKenna, Jack
Mavroudis, Ioannis
Doroftei, Bogdan
Ciobanu, Adela-Magdalena
Riga, Dan
author_facet Ilie, Ovidiu-Dumitru
Ciobica, Alin
Riga, Sorin
Dhunna, Nitasha
McKenna, Jack
Mavroudis, Ioannis
Doroftei, Bogdan
Ciobanu, Adela-Magdalena
Riga, Dan
author_sort Ilie, Ovidiu-Dumitru
collection PubMed
description Intra-lysosomal accumulation of the autofluorescent “residue” known as lipofuscin, which is found within postmitotic cells, remains controversial. Although it was considered a harmless hallmark of aging, its presence is detrimental as it continually accumulates. The latest evidence highlighted that lipofuscin strongly correlates with the excessive production of reactive oxygen species; however, despite this, lipofuscin cannot be removed by the biological recycling mechanisms. The antagonistic effects exerted at the DNA level culminate in a dysregulation of the cell cycle, by inducing a loss of the entire internal environment and abnormal gene(s) expression. Additionally, it appears that a crucial role in the production of reactive oxygen species can be attributed to gut microbiota, due to their ability to shape our behavior and neurodevelopment through their maintenance of the central nervous system.
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spelling pubmed-76993822020-11-29 Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality Ilie, Ovidiu-Dumitru Ciobica, Alin Riga, Sorin Dhunna, Nitasha McKenna, Jack Mavroudis, Ioannis Doroftei, Bogdan Ciobanu, Adela-Magdalena Riga, Dan Medicina (Kaunas) Review Intra-lysosomal accumulation of the autofluorescent “residue” known as lipofuscin, which is found within postmitotic cells, remains controversial. Although it was considered a harmless hallmark of aging, its presence is detrimental as it continually accumulates. The latest evidence highlighted that lipofuscin strongly correlates with the excessive production of reactive oxygen species; however, despite this, lipofuscin cannot be removed by the biological recycling mechanisms. The antagonistic effects exerted at the DNA level culminate in a dysregulation of the cell cycle, by inducing a loss of the entire internal environment and abnormal gene(s) expression. Additionally, it appears that a crucial role in the production of reactive oxygen species can be attributed to gut microbiota, due to their ability to shape our behavior and neurodevelopment through their maintenance of the central nervous system. MDPI 2020-11-19 /pmc/articles/PMC7699382/ /pubmed/33228124 http://dx.doi.org/10.3390/medicina56110626 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ilie, Ovidiu-Dumitru
Ciobica, Alin
Riga, Sorin
Dhunna, Nitasha
McKenna, Jack
Mavroudis, Ioannis
Doroftei, Bogdan
Ciobanu, Adela-Magdalena
Riga, Dan
Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality
title Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality
title_full Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality
title_fullStr Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality
title_full_unstemmed Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality
title_short Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality
title_sort mini-review on lipofuscin and aging: focusing on the molecular interface, the biological recycling mechanism, oxidative stress, and the gut-brain axis functionality
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699382/
https://www.ncbi.nlm.nih.gov/pubmed/33228124
http://dx.doi.org/10.3390/medicina56110626
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