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Deimination, Intermediate Filaments and Associated Proteins

Deimination (or citrullination) is a post-translational modification catalyzed by a calcium-dependent enzyme family of five peptidylarginine deiminases (PADs). Deimination is involved in physiological processes (cell differentiation, embryogenesis, innate and adaptive immunity, etc.) and in autoimmu...

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Autores principales: Briot, Julie, Simon, Michel, Méchin, Marie-Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699402/
https://www.ncbi.nlm.nih.gov/pubmed/33228136
http://dx.doi.org/10.3390/ijms21228746
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author Briot, Julie
Simon, Michel
Méchin, Marie-Claire
author_facet Briot, Julie
Simon, Michel
Méchin, Marie-Claire
author_sort Briot, Julie
collection PubMed
description Deimination (or citrullination) is a post-translational modification catalyzed by a calcium-dependent enzyme family of five peptidylarginine deiminases (PADs). Deimination is involved in physiological processes (cell differentiation, embryogenesis, innate and adaptive immunity, etc.) and in autoimmune diseases (rheumatoid arthritis, multiple sclerosis and lupus), cancers and neurodegenerative diseases. Intermediate filaments (IF) and associated proteins (IFAP) are major substrates of PADs. Here, we focus on the effects of deimination on the polymerization and solubility properties of IF proteins and on the proteolysis and cross-linking of IFAP, to finally expose some features of interest and some limitations of citrullinomes.
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spelling pubmed-76994022020-11-29 Deimination, Intermediate Filaments and Associated Proteins Briot, Julie Simon, Michel Méchin, Marie-Claire Int J Mol Sci Review Deimination (or citrullination) is a post-translational modification catalyzed by a calcium-dependent enzyme family of five peptidylarginine deiminases (PADs). Deimination is involved in physiological processes (cell differentiation, embryogenesis, innate and adaptive immunity, etc.) and in autoimmune diseases (rheumatoid arthritis, multiple sclerosis and lupus), cancers and neurodegenerative diseases. Intermediate filaments (IF) and associated proteins (IFAP) are major substrates of PADs. Here, we focus on the effects of deimination on the polymerization and solubility properties of IF proteins and on the proteolysis and cross-linking of IFAP, to finally expose some features of interest and some limitations of citrullinomes. MDPI 2020-11-19 /pmc/articles/PMC7699402/ /pubmed/33228136 http://dx.doi.org/10.3390/ijms21228746 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Briot, Julie
Simon, Michel
Méchin, Marie-Claire
Deimination, Intermediate Filaments and Associated Proteins
title Deimination, Intermediate Filaments and Associated Proteins
title_full Deimination, Intermediate Filaments and Associated Proteins
title_fullStr Deimination, Intermediate Filaments and Associated Proteins
title_full_unstemmed Deimination, Intermediate Filaments and Associated Proteins
title_short Deimination, Intermediate Filaments and Associated Proteins
title_sort deimination, intermediate filaments and associated proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699402/
https://www.ncbi.nlm.nih.gov/pubmed/33228136
http://dx.doi.org/10.3390/ijms21228746
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