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Fucoidan Characterization: Determination of Purity and Physicochemical and Chemical Properties
Fucoidans are marine sulfated biopolysaccharides that have heterogenous and complicated chemical structures. Various sugar monomers, glycosidic linkages, molecular masses, branching sites, and sulfate ester pattern and content are involved within their backbones. Additionally, sources, downstream pr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699409/ https://www.ncbi.nlm.nih.gov/pubmed/33228066 http://dx.doi.org/10.3390/md18110571 |
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author | Zayed, Ahmed El-Aasr, Mona Ibrahim, Abdel-Rahim S. Ulber, Roland |
author_facet | Zayed, Ahmed El-Aasr, Mona Ibrahim, Abdel-Rahim S. Ulber, Roland |
author_sort | Zayed, Ahmed |
collection | PubMed |
description | Fucoidans are marine sulfated biopolysaccharides that have heterogenous and complicated chemical structures. Various sugar monomers, glycosidic linkages, molecular masses, branching sites, and sulfate ester pattern and content are involved within their backbones. Additionally, sources, downstream processes, and geographical and seasonal factors show potential effects on fucoidan structural characteristics. These characteristics are documented to be highly related to fucoidan potential activities. Therefore, numerous chemical qualitative and quantitative determinations and structural elucidation methods are conducted to characterize fucoidans regarding their physicochemical and chemical features. Characterization of fucoidan polymers is considered a bottleneck for further biological and industrial applications. Consequently, the obtained results may be related to different activities, which could be improved afterward by further functional modifications. The current article highlights the different spectrometric and nonspectrometric methods applied for the characterization of native fucoidans, including degree of purity, sugar monomeric composition, sulfation pattern and content, molecular mass, and glycosidic linkages. |
format | Online Article Text |
id | pubmed-7699409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76994092020-11-29 Fucoidan Characterization: Determination of Purity and Physicochemical and Chemical Properties Zayed, Ahmed El-Aasr, Mona Ibrahim, Abdel-Rahim S. Ulber, Roland Mar Drugs Review Fucoidans are marine sulfated biopolysaccharides that have heterogenous and complicated chemical structures. Various sugar monomers, glycosidic linkages, molecular masses, branching sites, and sulfate ester pattern and content are involved within their backbones. Additionally, sources, downstream processes, and geographical and seasonal factors show potential effects on fucoidan structural characteristics. These characteristics are documented to be highly related to fucoidan potential activities. Therefore, numerous chemical qualitative and quantitative determinations and structural elucidation methods are conducted to characterize fucoidans regarding their physicochemical and chemical features. Characterization of fucoidan polymers is considered a bottleneck for further biological and industrial applications. Consequently, the obtained results may be related to different activities, which could be improved afterward by further functional modifications. The current article highlights the different spectrometric and nonspectrometric methods applied for the characterization of native fucoidans, including degree of purity, sugar monomeric composition, sulfation pattern and content, molecular mass, and glycosidic linkages. MDPI 2020-11-19 /pmc/articles/PMC7699409/ /pubmed/33228066 http://dx.doi.org/10.3390/md18110571 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zayed, Ahmed El-Aasr, Mona Ibrahim, Abdel-Rahim S. Ulber, Roland Fucoidan Characterization: Determination of Purity and Physicochemical and Chemical Properties |
title | Fucoidan Characterization: Determination of Purity and Physicochemical and Chemical Properties |
title_full | Fucoidan Characterization: Determination of Purity and Physicochemical and Chemical Properties |
title_fullStr | Fucoidan Characterization: Determination of Purity and Physicochemical and Chemical Properties |
title_full_unstemmed | Fucoidan Characterization: Determination of Purity and Physicochemical and Chemical Properties |
title_short | Fucoidan Characterization: Determination of Purity and Physicochemical and Chemical Properties |
title_sort | fucoidan characterization: determination of purity and physicochemical and chemical properties |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699409/ https://www.ncbi.nlm.nih.gov/pubmed/33228066 http://dx.doi.org/10.3390/md18110571 |
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