PLGA Nanoparticle Platform for Trans-Ocular Barrier to Enhance Drug Delivery: A Comparative Study Based on the Application of Oligosaccharides in the Outer Membrane of Carriers

PURPOSE: The trans-ocular barrier is a key factor limiting the therapeutic efficacy of triamcinolone acetonide. We developed a poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) surface modified respectively with 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD), chitosan oligosaccharide and trehalose....

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Detalles Bibliográficos
Autores principales: Jiang, Ge, Jia, Huanhuan, Qiu, Jindi, Mo, Zhenjie, Wen, Yifeng, Zhang, Yan, Wen, Yuqin, Xie, Qingchun, Ban, Junfeng, Lu, Zhufen, Chen, Yanzhong, Wu, Hao, Ni, Qingchun, Chen, Fohua, Lu, Jiashu, Wang, Zhijiong, Li, Haoting, Chen, Junming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699454/
https://www.ncbi.nlm.nih.gov/pubmed/33262593
http://dx.doi.org/10.2147/IJN.S272750

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