Nimotuzumab Site-Specifically Labeled with (89)Zr and (225)Ac Using SpyTag/SpyCatcher for PET Imaging and Alpha Particle Radioimmunotherapy of Epidermal Growth Factor Receptor Positive Cancers

SIMPLE SUMMARY: Monoclonal antibodies (IgG) are excellent probes for targeting cell surface receptors for imaging and therapeutic applications. These theranostic agents are often developed by randomly conjugating radioisotopes/drugs/chelators to the primary amine of lysine or the sulfhydryl groups o...

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Detalles Bibliográficos
Autores principales: Solomon, Viswas Raja, Barreto, Kris, Bernhard, Wendy, Alizadeh, Elahe, Causey, Patrick, Perron, Randy, Gendron, Denise, Alam, Md. Kausar, Carr, Adriana, Geyer, C. Ronald, Fonge, Humphrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699480/
https://www.ncbi.nlm.nih.gov/pubmed/33233524
http://dx.doi.org/10.3390/cancers12113449

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