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Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease

Respiratory diseases place an immense burden on global health and there is a compelling need for the discovery of new compounds for therapeutic development. Here, we identify research priorities by critically reviewing pre-clinical and clinical studies using extracts and compounds derived from mollu...

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Autores principales: Summer, Kate, Browne, Jessica, Liu, Lei, Benkendorff, Kirsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699502/
https://www.ncbi.nlm.nih.gov/pubmed/33228163
http://dx.doi.org/10.3390/md18110570
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author Summer, Kate
Browne, Jessica
Liu, Lei
Benkendorff, Kirsten
author_facet Summer, Kate
Browne, Jessica
Liu, Lei
Benkendorff, Kirsten
author_sort Summer, Kate
collection PubMed
description Respiratory diseases place an immense burden on global health and there is a compelling need for the discovery of new compounds for therapeutic development. Here, we identify research priorities by critically reviewing pre-clinical and clinical studies using extracts and compounds derived from molluscs, as well as traditional molluscan medicines, used in the treatment of respiratory diseases. We reviewed 97 biomedical articles demonstrating the anti-inflammatory, antimicrobial, anticancer, and immunomodulatory properties of >320 molluscan extracts/compounds with direct relevance to respiratory disease, in addition to others with promising bioactivities yet to be tested in the respiratory context. Of pertinent interest are compounds demonstrating biofilm inhibition/disruption and antiviral activity, as well as synergism with approved antimicrobial and chemotherapeutic agents. At least 100 traditional medicines, incorporating over 300 different mollusc species, have been used to treat respiratory-related illness in cultures worldwide for thousands of years. These medicines provide useful clues for the discovery of bioactive components that likely underpin their continued use. There is particular incentive for investigations into anti-inflammatory compounds, given the extensive application of molluscan traditional medicines for symptoms of inflammation, and shells, which are the principal molluscan product used in these preparations. Overall, there is a need to target research toward specific respiratory disease-related hypotheses, purify bioactive compounds and elucidate their chemical structures, and develop an evidence base for the integration of quality-controlled traditional medicines.
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spelling pubmed-76995022020-11-29 Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease Summer, Kate Browne, Jessica Liu, Lei Benkendorff, Kirsten Mar Drugs Review Respiratory diseases place an immense burden on global health and there is a compelling need for the discovery of new compounds for therapeutic development. Here, we identify research priorities by critically reviewing pre-clinical and clinical studies using extracts and compounds derived from molluscs, as well as traditional molluscan medicines, used in the treatment of respiratory diseases. We reviewed 97 biomedical articles demonstrating the anti-inflammatory, antimicrobial, anticancer, and immunomodulatory properties of >320 molluscan extracts/compounds with direct relevance to respiratory disease, in addition to others with promising bioactivities yet to be tested in the respiratory context. Of pertinent interest are compounds demonstrating biofilm inhibition/disruption and antiviral activity, as well as synergism with approved antimicrobial and chemotherapeutic agents. At least 100 traditional medicines, incorporating over 300 different mollusc species, have been used to treat respiratory-related illness in cultures worldwide for thousands of years. These medicines provide useful clues for the discovery of bioactive components that likely underpin their continued use. There is particular incentive for investigations into anti-inflammatory compounds, given the extensive application of molluscan traditional medicines for symptoms of inflammation, and shells, which are the principal molluscan product used in these preparations. Overall, there is a need to target research toward specific respiratory disease-related hypotheses, purify bioactive compounds and elucidate their chemical structures, and develop an evidence base for the integration of quality-controlled traditional medicines. MDPI 2020-11-19 /pmc/articles/PMC7699502/ /pubmed/33228163 http://dx.doi.org/10.3390/md18110570 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Summer, Kate
Browne, Jessica
Liu, Lei
Benkendorff, Kirsten
Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease
title Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease
title_full Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease
title_fullStr Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease
title_full_unstemmed Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease
title_short Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease
title_sort molluscan compounds provide drug leads for the treatment and prevention of respiratory disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699502/
https://www.ncbi.nlm.nih.gov/pubmed/33228163
http://dx.doi.org/10.3390/md18110570
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