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Predictors of HbA1c among Adipocytokine Biomarkers in African-American Men with Varied Glucose Tolerance
This study explored adipocytokine associations with acute and chronic hyperglycemia in African-American men (AAM). Fourteen adipocytokines were measured from men with normal glucose tolerance (NGT) or type 2 diabetes (T2D, drug-naïve MF(−) or using metformin MF(+)). Acute and chronic hyperglycemia w...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699586/ https://www.ncbi.nlm.nih.gov/pubmed/33233515 http://dx.doi.org/10.3390/biomedicines8110520 |
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author | Barengolts, Elena Akbar, Arfana Layden, Brian T. Eisenberg, Yuval Priyadarshini, Medha Borgia, Jeffrey A. Fhied, Cristina L. Salim, Michael Dugas, Lara R. |
author_facet | Barengolts, Elena Akbar, Arfana Layden, Brian T. Eisenberg, Yuval Priyadarshini, Medha Borgia, Jeffrey A. Fhied, Cristina L. Salim, Michael Dugas, Lara R. |
author_sort | Barengolts, Elena |
collection | PubMed |
description | This study explored adipocytokine associations with acute and chronic hyperglycemia in African-American men (AAM). Fourteen adipocytokines were measured from men with normal glucose tolerance (NGT) or type 2 diabetes (T2D, drug-naïve MF(−) or using metformin MF(+)). Acute and chronic hyperglycemia were evaluated by 120 min oral glucose tolerance test (OGTT) and glycohemoglobin A1c (HbA1c). AAM with T2D (n = 21) compared to NGT (n = 20) were older, had higher BMI and slightly higher glucose and insulin. In the fasted state, TNF-α, IL-6, PAI-1, IL-13, adiponectin, adipsin, and lipocalin were lower in T2D vs. NGT. At 120 min post-glucose load, TNF-α, IL-6, IL-13, IL-8, PAI-1, adiponectin, adipsin, lipocalin, and resistin were lower in T2D vs. NGT. There were no statistical differences for GM-CSF, IL-7, IL-10, IP-10, and MCP-1. Regression analysis showed that fasting IL-8, TNF-α, adiponectin, lipocalin, resistin, adipsin, and PAI-1 were associated with HbA1c. After adjusting for age, BMI, glucose tolerance, and metformin use, only adipsin remained significantly associated with HbA1c (p = 0.021). The model including adipsin, TNF-α, age, BMI, and group designation (i.e., NGT, MF(−), MF(+)) explained 86% of HbA1c variability. The data suggested that adipsin could be associated with HbA1c in AAM with varied glucose tolerance. |
format | Online Article Text |
id | pubmed-7699586 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76995862020-11-29 Predictors of HbA1c among Adipocytokine Biomarkers in African-American Men with Varied Glucose Tolerance Barengolts, Elena Akbar, Arfana Layden, Brian T. Eisenberg, Yuval Priyadarshini, Medha Borgia, Jeffrey A. Fhied, Cristina L. Salim, Michael Dugas, Lara R. Biomedicines Article This study explored adipocytokine associations with acute and chronic hyperglycemia in African-American men (AAM). Fourteen adipocytokines were measured from men with normal glucose tolerance (NGT) or type 2 diabetes (T2D, drug-naïve MF(−) or using metformin MF(+)). Acute and chronic hyperglycemia were evaluated by 120 min oral glucose tolerance test (OGTT) and glycohemoglobin A1c (HbA1c). AAM with T2D (n = 21) compared to NGT (n = 20) were older, had higher BMI and slightly higher glucose and insulin. In the fasted state, TNF-α, IL-6, PAI-1, IL-13, adiponectin, adipsin, and lipocalin were lower in T2D vs. NGT. At 120 min post-glucose load, TNF-α, IL-6, IL-13, IL-8, PAI-1, adiponectin, adipsin, lipocalin, and resistin were lower in T2D vs. NGT. There were no statistical differences for GM-CSF, IL-7, IL-10, IP-10, and MCP-1. Regression analysis showed that fasting IL-8, TNF-α, adiponectin, lipocalin, resistin, adipsin, and PAI-1 were associated with HbA1c. After adjusting for age, BMI, glucose tolerance, and metformin use, only adipsin remained significantly associated with HbA1c (p = 0.021). The model including adipsin, TNF-α, age, BMI, and group designation (i.e., NGT, MF(−), MF(+)) explained 86% of HbA1c variability. The data suggested that adipsin could be associated with HbA1c in AAM with varied glucose tolerance. MDPI 2020-11-20 /pmc/articles/PMC7699586/ /pubmed/33233515 http://dx.doi.org/10.3390/biomedicines8110520 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Barengolts, Elena Akbar, Arfana Layden, Brian T. Eisenberg, Yuval Priyadarshini, Medha Borgia, Jeffrey A. Fhied, Cristina L. Salim, Michael Dugas, Lara R. Predictors of HbA1c among Adipocytokine Biomarkers in African-American Men with Varied Glucose Tolerance |
title | Predictors of HbA1c among Adipocytokine Biomarkers in African-American Men with Varied Glucose Tolerance |
title_full | Predictors of HbA1c among Adipocytokine Biomarkers in African-American Men with Varied Glucose Tolerance |
title_fullStr | Predictors of HbA1c among Adipocytokine Biomarkers in African-American Men with Varied Glucose Tolerance |
title_full_unstemmed | Predictors of HbA1c among Adipocytokine Biomarkers in African-American Men with Varied Glucose Tolerance |
title_short | Predictors of HbA1c among Adipocytokine Biomarkers in African-American Men with Varied Glucose Tolerance |
title_sort | predictors of hba1c among adipocytokine biomarkers in african-american men with varied glucose tolerance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699586/ https://www.ncbi.nlm.nih.gov/pubmed/33233515 http://dx.doi.org/10.3390/biomedicines8110520 |
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