Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma

Drug resistance and dose-limiting toxicities are significant barriers for treatment of multiple myeloma (MM). Bone marrow microenvironment (BMME) plays a major role in drug resistance in MM. Drug delivery with targeted nanoparticles have been shown to improve specificity and efficacy and reduce toxi...

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Detalles Bibliográficos
Autores principales: Federico, Cinzia, Alhallak, Kinan, Sun, Jennifer, Duncan, Kathleen, Azab, Feda, Sudlow, Gail P., de la Puente, Pilar, Muz, Barbara, Kapoor, Vaishali, Zhang, Luna, Yuan, Fangzheng, Markovic, Matea, Kotsybar, Joseph, Wasden, Katherine, Guenthner, Nicole, Gurley, Shannon, King, Justin, Kohnen, Daniel, Salama, Noha N., Thotala, Dinesh, Hallahan, Dennis E., Vij, Ravi, DiPersio, John F., Achilefu, Samuel, Azab, Abdel Kareem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699624/
https://www.ncbi.nlm.nih.gov/pubmed/33247158
http://dx.doi.org/10.1038/s41467-020-19932-1

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