Ligand-induced conformational rearrangements regulate the switch between membrane-proximal and distal functions of Rho kinase 2

Rho-associated protein kinase 2 (ROCK2) is a membrane-anchored, long, flexible, multidomain, multifunctional protein. Its functions can be divided into two categories: membrane-proximal and membrane-distal. A recent study concluded that membrane-distal functions require the fully extended conformati...

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Detalles Bibliográficos
Autores principales: Hajdú, István, Szilágyi, András, Végh, Barbara M., Wacha, András, Györffy, Dániel, Gráczer, Éva, Somogyi, Márk, Gál, Péter, Závodszky, Péter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699638/
https://www.ncbi.nlm.nih.gov/pubmed/33247217
http://dx.doi.org/10.1038/s42003-020-01450-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699638/
https://www.ncbi.nlm.nih.gov/pubmed/33247217
http://dx.doi.org/10.1038/s42003-020-01450-x

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