A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy

Antimicrobial peptides (AMPs) are a potential alternative to classical antibiotics that are yet to achieve a therapeutic breakthrough for treatment of systemic infections. The antibacterial potency of pleurocidin, an AMP from Winter Flounder, is linked to its ability to cross bacterial plasma membra...

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Detalles Bibliográficos
Autores principales: Manzo, Giorgia, Hind, Charlotte K., Ferguson, Philip M., Amison, Richard T., Hodgson-Casson, Alice C., Ciazynska, Katarzyna A., Weller, Bethany J., Clarke, Maria, Lam, Carolyn, Man, Rico C. H., Shaughnessy, Blaze G. O’, Clifford, Melanie, Bui, Tam T., Drake, Alex F., Atkinson, R. Andrew, Lam, Jenny K. W., Pitchford, Simon C., Page, Clive P., Phoenix, David A., Lorenz, Christian D., Sutton, J. Mark, Mason, A. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699649/
https://www.ncbi.nlm.nih.gov/pubmed/33247193
http://dx.doi.org/10.1038/s42003-020-01420-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699649/
https://www.ncbi.nlm.nih.gov/pubmed/33247193
http://dx.doi.org/10.1038/s42003-020-01420-3

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