Efficacy of Intravenous Hydrocortisone Treatment in Refractory Neonatal Seizures: A Report on Three Cases

Neonatal seizures are the most common neurological emergency, and neonatal status epilepticus (NSE) remains a controversial entity, with no general consensus about its definition and treatment. Here, we report on three newborns with NSE refractory to first- and second-line antiepileptic drugs succes...

Descripción completa

Detalles Bibliográficos
Autores principales: Di Rosa, Gabriella, Dicanio, Daniela, Nicotera, Antonio Gennaro, Mondello, Patrizia, Cannavò, Laura, Gitto, Eloisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699678/
https://www.ncbi.nlm.nih.gov/pubmed/33233684
http://dx.doi.org/10.3390/brainsci10110885
_version_ 1783616104155840512
author Di Rosa, Gabriella
Dicanio, Daniela
Nicotera, Antonio Gennaro
Mondello, Patrizia
Cannavò, Laura
Gitto, Eloisa
author_facet Di Rosa, Gabriella
Dicanio, Daniela
Nicotera, Antonio Gennaro
Mondello, Patrizia
Cannavò, Laura
Gitto, Eloisa
author_sort Di Rosa, Gabriella
collection PubMed
description Neonatal seizures are the most common neurological emergency, and neonatal status epilepticus (NSE) remains a controversial entity, with no general consensus about its definition and treatment. Here, we report on three newborns with NSE refractory to first- and second-line antiepileptic drugs successfully treated with intravenous (IV) hydrocortisone. The patients had previously failed therapy with levetiracetam, phenobarbital and midazolam, showing persistent clinical and electrical seizures. Modulation of brain inflammation triggered during prolonged epileptic activity has been thought to potentially explain the beneficial effects of anti-inflammatory treatment.
format Online
Article
Text
id pubmed-7699678
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-76996782020-11-29 Efficacy of Intravenous Hydrocortisone Treatment in Refractory Neonatal Seizures: A Report on Three Cases Di Rosa, Gabriella Dicanio, Daniela Nicotera, Antonio Gennaro Mondello, Patrizia Cannavò, Laura Gitto, Eloisa Brain Sci Case Report Neonatal seizures are the most common neurological emergency, and neonatal status epilepticus (NSE) remains a controversial entity, with no general consensus about its definition and treatment. Here, we report on three newborns with NSE refractory to first- and second-line antiepileptic drugs successfully treated with intravenous (IV) hydrocortisone. The patients had previously failed therapy with levetiracetam, phenobarbital and midazolam, showing persistent clinical and electrical seizures. Modulation of brain inflammation triggered during prolonged epileptic activity has been thought to potentially explain the beneficial effects of anti-inflammatory treatment. MDPI 2020-11-20 /pmc/articles/PMC7699678/ /pubmed/33233684 http://dx.doi.org/10.3390/brainsci10110885 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Di Rosa, Gabriella
Dicanio, Daniela
Nicotera, Antonio Gennaro
Mondello, Patrizia
Cannavò, Laura
Gitto, Eloisa
Efficacy of Intravenous Hydrocortisone Treatment in Refractory Neonatal Seizures: A Report on Three Cases
title Efficacy of Intravenous Hydrocortisone Treatment in Refractory Neonatal Seizures: A Report on Three Cases
title_full Efficacy of Intravenous Hydrocortisone Treatment in Refractory Neonatal Seizures: A Report on Three Cases
title_fullStr Efficacy of Intravenous Hydrocortisone Treatment in Refractory Neonatal Seizures: A Report on Three Cases
title_full_unstemmed Efficacy of Intravenous Hydrocortisone Treatment in Refractory Neonatal Seizures: A Report on Three Cases
title_short Efficacy of Intravenous Hydrocortisone Treatment in Refractory Neonatal Seizures: A Report on Three Cases
title_sort efficacy of intravenous hydrocortisone treatment in refractory neonatal seizures: a report on three cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699678/
https://www.ncbi.nlm.nih.gov/pubmed/33233684
http://dx.doi.org/10.3390/brainsci10110885
work_keys_str_mv AT dirosagabriella efficacyofintravenoushydrocortisonetreatmentinrefractoryneonatalseizuresareportonthreecases
AT dicaniodaniela efficacyofintravenoushydrocortisonetreatmentinrefractoryneonatalseizuresareportonthreecases
AT nicoteraantoniogennaro efficacyofintravenoushydrocortisonetreatmentinrefractoryneonatalseizuresareportonthreecases
AT mondellopatrizia efficacyofintravenoushydrocortisonetreatmentinrefractoryneonatalseizuresareportonthreecases
AT cannavolaura efficacyofintravenoushydrocortisonetreatmentinrefractoryneonatalseizuresareportonthreecases
AT gittoeloisa efficacyofintravenoushydrocortisonetreatmentinrefractoryneonatalseizuresareportonthreecases

Ejemplares similares