Cargando…
The Search for New Anticonvulsants in a Group of (2,5-Dioxopyrrolidin-1-yl)(phenyl)Acetamides with Hybrid Structure—Synthesis and In Vivo/In Vitro Studies
Epilepsy belongs to the most common and debilitating neurological disorders with multifactorial pathophysiology and a high level of drug resistance. Therefore, with the aim of searching for new, more effective, and/or safer therapeutics, we discovered a focused series of original hybrid pyrrolidine-...
Autores principales: | Abram, Michał, Jakubiec, Marcin, Rapacz, Anna, Mogilski, Szczepan, Latacz, Gniewomir, Kamiński, Rafał M., Kamiński, Krzysztof |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699745/ https://www.ncbi.nlm.nih.gov/pubmed/33233618 http://dx.doi.org/10.3390/ijms21228780 |
Ejemplares similares
-
Identification of New Compounds with Anticonvulsant and Antinociceptive Properties in a Group of 3-substituted (2,5-dioxo-pyrrolidin-1-yl)(phenyl)-Acetamides
por: Abram, Michał, et al.
Publicado: (2021) -
N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug
por: Kamiński, Krzysztof, et al.
Publicado: (2019) -
Discovery of
(R)-N-Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide
[(R)-AS-1], a Novel Orally Bioavailable
EAAT2
Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo
por: Abram, Michał, et al.
Publicado: (2022) -
Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy
por: Rapacz, Anna, et al.
Publicado: (2017) -
New Phenylglycinamide Derivatives with Hybrid Structure as Candidates for New Broad-Spectrum Anticonvulsants
por: Jakubiec, Marcin, et al.
Publicado: (2022)