Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons

Cancer is the second most fatal disease in the world and an early diagnosis is important for a successful treatment. Thus, it is necessary to develop fast, sensitive, simple, and inexpensive analytical tools for cancer biomarker detection. MicroRNA (miRNA) is an RNA cancer biomarker where the expres...

Descripción completa

Detalles Bibliográficos
Autores principales: El Aamri, Maliana, Yammouri, Ghita, Mohammadi, Hasna, Amine, Aziz, Korri-Youssoufi, Hafsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699780/
https://www.ncbi.nlm.nih.gov/pubmed/33233700
http://dx.doi.org/10.3390/bios10110186
_version_ 1783616128516358144
author El Aamri, Maliana
Yammouri, Ghita
Mohammadi, Hasna
Amine, Aziz
Korri-Youssoufi, Hafsa
author_facet El Aamri, Maliana
Yammouri, Ghita
Mohammadi, Hasna
Amine, Aziz
Korri-Youssoufi, Hafsa
author_sort El Aamri, Maliana
collection PubMed
description Cancer is the second most fatal disease in the world and an early diagnosis is important for a successful treatment. Thus, it is necessary to develop fast, sensitive, simple, and inexpensive analytical tools for cancer biomarker detection. MicroRNA (miRNA) is an RNA cancer biomarker where the expression level in body fluid is strongly correlated to cancer. Various biosensors involving the detection of miRNA for cancer diagnosis were developed. The present review offers a comprehensive overview of the recent developments in electrochemical biosensor for miRNA cancer marker detection from 2015 to 2020. The review focuses on the approaches to direct miRNA detection based on the electrochemical signal. It includes a RedOx-labeled probe with different designs, RedOx DNA-intercalating agents, various kinds of RedOx catalysts used to produce a signal response, and finally a free RedOx indicator. Furthermore, the advantages and drawbacks of these approaches are highlighted.
format Online
Article
Text
id pubmed-7699780
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-76997802020-11-29 Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons El Aamri, Maliana Yammouri, Ghita Mohammadi, Hasna Amine, Aziz Korri-Youssoufi, Hafsa Biosensors (Basel) Review Cancer is the second most fatal disease in the world and an early diagnosis is important for a successful treatment. Thus, it is necessary to develop fast, sensitive, simple, and inexpensive analytical tools for cancer biomarker detection. MicroRNA (miRNA) is an RNA cancer biomarker where the expression level in body fluid is strongly correlated to cancer. Various biosensors involving the detection of miRNA for cancer diagnosis were developed. The present review offers a comprehensive overview of the recent developments in electrochemical biosensor for miRNA cancer marker detection from 2015 to 2020. The review focuses on the approaches to direct miRNA detection based on the electrochemical signal. It includes a RedOx-labeled probe with different designs, RedOx DNA-intercalating agents, various kinds of RedOx catalysts used to produce a signal response, and finally a free RedOx indicator. Furthermore, the advantages and drawbacks of these approaches are highlighted. MDPI 2020-11-20 /pmc/articles/PMC7699780/ /pubmed/33233700 http://dx.doi.org/10.3390/bios10110186 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
El Aamri, Maliana
Yammouri, Ghita
Mohammadi, Hasna
Amine, Aziz
Korri-Youssoufi, Hafsa
Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons
title Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons
title_full Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons
title_fullStr Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons
title_full_unstemmed Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons
title_short Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons
title_sort electrochemical biosensors for detection of microrna as a cancer biomarker: pros and cons
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699780/
https://www.ncbi.nlm.nih.gov/pubmed/33233700
http://dx.doi.org/10.3390/bios10110186
work_keys_str_mv AT elaamrimaliana electrochemicalbiosensorsfordetectionofmicrornaasacancerbiomarkerprosandcons
AT yammourighita electrochemicalbiosensorsfordetectionofmicrornaasacancerbiomarkerprosandcons
AT mohammadihasna electrochemicalbiosensorsfordetectionofmicrornaasacancerbiomarkerprosandcons
AT amineaziz electrochemicalbiosensorsfordetectionofmicrornaasacancerbiomarkerprosandcons
AT korriyoussoufihafsa electrochemicalbiosensorsfordetectionofmicrornaasacancerbiomarkerprosandcons

Ejemplares similares