Possible A2E Mutagenic Effects on RPE Mitochondrial DNA from Innovative RNA-Seq Bioinformatics Pipeline

Mitochondria are subject to continuous oxidative stress stimuli that, over time, can impair their genome and lead to several pathologies, like retinal degenerations. Our main purpose was the identification of mtDNA variants that might be induced by intense oxidative stress determined by N-retinylide...

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Detalles Bibliográficos
Autores principales: Donato, Luigi, Scimone, Concetta, Alibrandi, Simona, Pitruzzella, Alessandro, Scalia, Federica, D’Angelo, Rosalia, Sidoti, Antonina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699917/
https://www.ncbi.nlm.nih.gov/pubmed/33233726
http://dx.doi.org/10.3390/antiox9111158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699917/
https://www.ncbi.nlm.nih.gov/pubmed/33233726
http://dx.doi.org/10.3390/antiox9111158

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