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New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems
New grafted copolymers possessing structural units of 1-vinyl-3-(1-carboxymethyl) imidazolium betaine were obtained by graft copolymerization of N-vinylimidazole onto gellan gum followed by the polymer-analogous reactions on grafted polymer with the highest grafting percentage using sodium chloroace...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699957/ https://www.ncbi.nlm.nih.gov/pubmed/33233752 http://dx.doi.org/10.3390/molecules25225451 |
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author | Racovita, Stefania Baranov, Nicolae Macsim, Ana Maria Lionte, Catalina Cheptea, Corina Sunel, Valeriu Popa, Marcel Vasiliu, Silvia Desbrieres, Jacques |
author_facet | Racovita, Stefania Baranov, Nicolae Macsim, Ana Maria Lionte, Catalina Cheptea, Corina Sunel, Valeriu Popa, Marcel Vasiliu, Silvia Desbrieres, Jacques |
author_sort | Racovita, Stefania |
collection | PubMed |
description | New grafted copolymers possessing structural units of 1-vinyl-3-(1-carboxymethyl) imidazolium betaine were obtained by graft copolymerization of N-vinylimidazole onto gellan gum followed by the polymer-analogous reactions on grafted polymer with the highest grafting percentage using sodium chloroacetate as the betainization agent. The grafted copolymers were prepared using ammonium persulfate/N,N,N′,N′ tetramethylethylenediamine in a nitrogen atmosphere. The grafting reaction conditions were optimized by changing one of the following reaction parameters: initiator concentration, monomer concentration, polymer concentration, reaction time or temperature, while the other parameters remained constant. The highest grafting yield was obtained under the following reaction conditions: c(i) = 0.08 mol/L, c(m) = 0.8 mol/L, c(p) = 8 g/L, t(r) = 4 h and T = 50 °C. The kinetics of the graft copolymerization of N-vinylimidazole onto gellan was discussed and a suitable reaction mechanism was proposed. The evidence of the grafting reaction was confirmed through FTIR spectroscopy, X-ray diffraction, (1)H-NMR spectroscopy and scanning electron microscopy. The grafted copolymer with betaine structure was obtained by a nucleophilic substitution reaction where the betainization agent was sodium chloroacetate. Preliminary results prove the ability of the grafted copolymers to bind amphoteric drugs (cefotaxime) and, therefore, the possibility of developing the new sustained drug release systems. |
format | Online Article Text |
id | pubmed-7699957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76999572020-11-29 New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems Racovita, Stefania Baranov, Nicolae Macsim, Ana Maria Lionte, Catalina Cheptea, Corina Sunel, Valeriu Popa, Marcel Vasiliu, Silvia Desbrieres, Jacques Molecules Article New grafted copolymers possessing structural units of 1-vinyl-3-(1-carboxymethyl) imidazolium betaine were obtained by graft copolymerization of N-vinylimidazole onto gellan gum followed by the polymer-analogous reactions on grafted polymer with the highest grafting percentage using sodium chloroacetate as the betainization agent. The grafted copolymers were prepared using ammonium persulfate/N,N,N′,N′ tetramethylethylenediamine in a nitrogen atmosphere. The grafting reaction conditions were optimized by changing one of the following reaction parameters: initiator concentration, monomer concentration, polymer concentration, reaction time or temperature, while the other parameters remained constant. The highest grafting yield was obtained under the following reaction conditions: c(i) = 0.08 mol/L, c(m) = 0.8 mol/L, c(p) = 8 g/L, t(r) = 4 h and T = 50 °C. The kinetics of the graft copolymerization of N-vinylimidazole onto gellan was discussed and a suitable reaction mechanism was proposed. The evidence of the grafting reaction was confirmed through FTIR spectroscopy, X-ray diffraction, (1)H-NMR spectroscopy and scanning electron microscopy. The grafted copolymer with betaine structure was obtained by a nucleophilic substitution reaction where the betainization agent was sodium chloroacetate. Preliminary results prove the ability of the grafted copolymers to bind amphoteric drugs (cefotaxime) and, therefore, the possibility of developing the new sustained drug release systems. MDPI 2020-11-20 /pmc/articles/PMC7699957/ /pubmed/33233752 http://dx.doi.org/10.3390/molecules25225451 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Racovita, Stefania Baranov, Nicolae Macsim, Ana Maria Lionte, Catalina Cheptea, Corina Sunel, Valeriu Popa, Marcel Vasiliu, Silvia Desbrieres, Jacques New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems |
title | New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems |
title_full | New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems |
title_fullStr | New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems |
title_full_unstemmed | New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems |
title_short | New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems |
title_sort | new grafted copolymers carrying betaine units based on gellan and n-vinylimidazole as precursors for design of drug delivery systems |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699957/ https://www.ncbi.nlm.nih.gov/pubmed/33233752 http://dx.doi.org/10.3390/molecules25225451 |
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