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New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems

New grafted copolymers possessing structural units of 1-vinyl-3-(1-carboxymethyl) imidazolium betaine were obtained by graft copolymerization of N-vinylimidazole onto gellan gum followed by the polymer-analogous reactions on grafted polymer with the highest grafting percentage using sodium chloroace...

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Autores principales: Racovita, Stefania, Baranov, Nicolae, Macsim, Ana Maria, Lionte, Catalina, Cheptea, Corina, Sunel, Valeriu, Popa, Marcel, Vasiliu, Silvia, Desbrieres, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699957/
https://www.ncbi.nlm.nih.gov/pubmed/33233752
http://dx.doi.org/10.3390/molecules25225451
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author Racovita, Stefania
Baranov, Nicolae
Macsim, Ana Maria
Lionte, Catalina
Cheptea, Corina
Sunel, Valeriu
Popa, Marcel
Vasiliu, Silvia
Desbrieres, Jacques
author_facet Racovita, Stefania
Baranov, Nicolae
Macsim, Ana Maria
Lionte, Catalina
Cheptea, Corina
Sunel, Valeriu
Popa, Marcel
Vasiliu, Silvia
Desbrieres, Jacques
author_sort Racovita, Stefania
collection PubMed
description New grafted copolymers possessing structural units of 1-vinyl-3-(1-carboxymethyl) imidazolium betaine were obtained by graft copolymerization of N-vinylimidazole onto gellan gum followed by the polymer-analogous reactions on grafted polymer with the highest grafting percentage using sodium chloroacetate as the betainization agent. The grafted copolymers were prepared using ammonium persulfate/N,N,N′,N′ tetramethylethylenediamine in a nitrogen atmosphere. The grafting reaction conditions were optimized by changing one of the following reaction parameters: initiator concentration, monomer concentration, polymer concentration, reaction time or temperature, while the other parameters remained constant. The highest grafting yield was obtained under the following reaction conditions: c(i) = 0.08 mol/L, c(m) = 0.8 mol/L, c(p) = 8 g/L, t(r) = 4 h and T = 50 °C. The kinetics of the graft copolymerization of N-vinylimidazole onto gellan was discussed and a suitable reaction mechanism was proposed. The evidence of the grafting reaction was confirmed through FTIR spectroscopy, X-ray diffraction, (1)H-NMR spectroscopy and scanning electron microscopy. The grafted copolymer with betaine structure was obtained by a nucleophilic substitution reaction where the betainization agent was sodium chloroacetate. Preliminary results prove the ability of the grafted copolymers to bind amphoteric drugs (cefotaxime) and, therefore, the possibility of developing the new sustained drug release systems.
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spelling pubmed-76999572020-11-29 New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems Racovita, Stefania Baranov, Nicolae Macsim, Ana Maria Lionte, Catalina Cheptea, Corina Sunel, Valeriu Popa, Marcel Vasiliu, Silvia Desbrieres, Jacques Molecules Article New grafted copolymers possessing structural units of 1-vinyl-3-(1-carboxymethyl) imidazolium betaine were obtained by graft copolymerization of N-vinylimidazole onto gellan gum followed by the polymer-analogous reactions on grafted polymer with the highest grafting percentage using sodium chloroacetate as the betainization agent. The grafted copolymers were prepared using ammonium persulfate/N,N,N′,N′ tetramethylethylenediamine in a nitrogen atmosphere. The grafting reaction conditions were optimized by changing one of the following reaction parameters: initiator concentration, monomer concentration, polymer concentration, reaction time or temperature, while the other parameters remained constant. The highest grafting yield was obtained under the following reaction conditions: c(i) = 0.08 mol/L, c(m) = 0.8 mol/L, c(p) = 8 g/L, t(r) = 4 h and T = 50 °C. The kinetics of the graft copolymerization of N-vinylimidazole onto gellan was discussed and a suitable reaction mechanism was proposed. The evidence of the grafting reaction was confirmed through FTIR spectroscopy, X-ray diffraction, (1)H-NMR spectroscopy and scanning electron microscopy. The grafted copolymer with betaine structure was obtained by a nucleophilic substitution reaction where the betainization agent was sodium chloroacetate. Preliminary results prove the ability of the grafted copolymers to bind amphoteric drugs (cefotaxime) and, therefore, the possibility of developing the new sustained drug release systems. MDPI 2020-11-20 /pmc/articles/PMC7699957/ /pubmed/33233752 http://dx.doi.org/10.3390/molecules25225451 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Racovita, Stefania
Baranov, Nicolae
Macsim, Ana Maria
Lionte, Catalina
Cheptea, Corina
Sunel, Valeriu
Popa, Marcel
Vasiliu, Silvia
Desbrieres, Jacques
New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems
title New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems
title_full New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems
title_fullStr New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems
title_full_unstemmed New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems
title_short New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems
title_sort new grafted copolymers carrying betaine units based on gellan and n-vinylimidazole as precursors for design of drug delivery systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699957/
https://www.ncbi.nlm.nih.gov/pubmed/33233752
http://dx.doi.org/10.3390/molecules25225451
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