Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver

COVID-19 is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early reported symptoms include fever, cough, and respiratory symptoms. There were few reports of digestive symptoms. However, with COVID-19 spreading worldwide, symptoms such as vomiting, diarrhoea, and a...

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Detalles Bibliográficos
Autores principales: Lei, Han-Yu, Ding, Ying-He, Nie, Kai, Dong, Yin-Miao, Xu, Jia-Hao, Yang, Meng-Ling, Liu, Meng-Qi, Wei, Le, Nasser, MI, Xu, Lin-Yong, Zhu, Ping, Zhao, Ming-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Masson SAS. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700011/
https://www.ncbi.nlm.nih.gov/pubmed/33378966
http://dx.doi.org/10.1016/j.biopha.2020.111064
Descripción
Sumario:COVID-19 is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early reported symptoms include fever, cough, and respiratory symptoms. There were few reports of digestive symptoms. However, with COVID-19 spreading worldwide, symptoms such as vomiting, diarrhoea, and abdominal pain have gained increasing attention. Research has found that angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 receptor, is strongly expressed in the gastrointestinal tract and liver. Whether theoretically or clinically, many studies have suggested a close connection between COVID-19 and the digestive system. In this review, we summarize the digestive symptoms reported in existing research, discuss the impact of SARS-CoV-2 on the gastrointestinal tract and liver, and determine the possible mechanisms and aetiology, such as cytokine storm. In-depth exploration of the relationship between COVID-19 and the digestive system is urgently needed.

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