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Selective Ablation of Descending Serotonin from the Rostral Ventromedial Medulla Unmasks Its Pro-Nociceptive Role in Chemotherapy-Induced Painful Neuropathy

PURPOSE: Chemotherapy-induced painful neuropathy (CIPN) is a severe adverse effect of many anti-neoplastic drugs that is difficult to manage. Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter in the rostral ventromedial medulla (RVM), which modulates descending spinal nociceptiv...

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Detalles Bibliográficos
Autores principales:	Liu, Xijiang, Wang, Gongming, Ai, Geyi, Xu, Xiqiang, Niu, Xinhuan, Zhang, Mengyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700091/ https://www.ncbi.nlm.nih.gov/pubmed/33262643 http://dx.doi.org/10.2147/JPR.S275254

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