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Deformable Liposomal Hydrogel for Dermal and Transdermal Delivery of Meloxicam

BACKGROUND AND AIM: Meloxicam (MX) is a potent hydrophobic non-steroidal anti-inflammatory drug used to reduce inflammation and pain. However, its oral dosage form can cause many adverse gastrointestinal effects. In the present study, a poloxamer P407 based hydrogel system containing transfersomes o...

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Autores principales: Zhang, Zhang Julia, Osmałek, Tomasz, Michniak-Kohn, Bozena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700092/
https://www.ncbi.nlm.nih.gov/pubmed/33262590
http://dx.doi.org/10.2147/IJN.S274954
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author Zhang, Zhang Julia
Osmałek, Tomasz
Michniak-Kohn, Bozena
author_facet Zhang, Zhang Julia
Osmałek, Tomasz
Michniak-Kohn, Bozena
author_sort Zhang, Zhang Julia
collection PubMed
description BACKGROUND AND AIM: Meloxicam (MX) is a potent hydrophobic non-steroidal anti-inflammatory drug used to reduce inflammation and pain. However, its oral dosage form can cause many adverse gastrointestinal effects. In the present study, a poloxamer P407 based hydrogel system containing transfersomes or flavosomes has been prepared as a potential therapeutic vehicle for the topical delivery of MX. METHODS: In this study, MX was encapsulated in conventional liposomes, transfersomes, and flavosomes. The obtained liposomal vesicles were characterized in terms of size, drug entrapment efficiency, zeta potential, and stability. These MX-loaded liposomal formulations were further incorporated into a poloxamer P407 gel and evaluated using rheological properties, a stability study and an ex vivo permeation study through human cadaver skin by both HPLC analysis and confocal laser scanning microscopy (CLSM). RESULTS: The developed deformable liposomes exhibited homogeneous vesicle sizes less than 120 nm with a higher entrapment efficiency as compared to conventional liposomes. The deformable liposomal gel formulations showed improved permeability compared to a conventional liposomal gel and a liposome-free gel. The enhancement effect was also clearly visible by CLSM. CONCLUSION: These deformable liposomal hydrogel formulations can be a promising alternative to conventional oral delivery of MX by topical administration. Notably, flavosome-loaded gel formulations displayed the highest permeability through the deeper layers of the skin and shortened lag time, indicating a potential faster on-site pain relief and anti-inflammatory effect.
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spelling pubmed-77000922020-11-30 Deformable Liposomal Hydrogel for Dermal and Transdermal Delivery of Meloxicam Zhang, Zhang Julia Osmałek, Tomasz Michniak-Kohn, Bozena Int J Nanomedicine Original Research BACKGROUND AND AIM: Meloxicam (MX) is a potent hydrophobic non-steroidal anti-inflammatory drug used to reduce inflammation and pain. However, its oral dosage form can cause many adverse gastrointestinal effects. In the present study, a poloxamer P407 based hydrogel system containing transfersomes or flavosomes has been prepared as a potential therapeutic vehicle for the topical delivery of MX. METHODS: In this study, MX was encapsulated in conventional liposomes, transfersomes, and flavosomes. The obtained liposomal vesicles were characterized in terms of size, drug entrapment efficiency, zeta potential, and stability. These MX-loaded liposomal formulations were further incorporated into a poloxamer P407 gel and evaluated using rheological properties, a stability study and an ex vivo permeation study through human cadaver skin by both HPLC analysis and confocal laser scanning microscopy (CLSM). RESULTS: The developed deformable liposomes exhibited homogeneous vesicle sizes less than 120 nm with a higher entrapment efficiency as compared to conventional liposomes. The deformable liposomal gel formulations showed improved permeability compared to a conventional liposomal gel and a liposome-free gel. The enhancement effect was also clearly visible by CLSM. CONCLUSION: These deformable liposomal hydrogel formulations can be a promising alternative to conventional oral delivery of MX by topical administration. Notably, flavosome-loaded gel formulations displayed the highest permeability through the deeper layers of the skin and shortened lag time, indicating a potential faster on-site pain relief and anti-inflammatory effect. Dove 2020-11-24 /pmc/articles/PMC7700092/ /pubmed/33262590 http://dx.doi.org/10.2147/IJN.S274954 Text en © 2020 Zhang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Zhang, Zhang Julia
Osmałek, Tomasz
Michniak-Kohn, Bozena
Deformable Liposomal Hydrogel for Dermal and Transdermal Delivery of Meloxicam
title Deformable Liposomal Hydrogel for Dermal and Transdermal Delivery of Meloxicam
title_full Deformable Liposomal Hydrogel for Dermal and Transdermal Delivery of Meloxicam
title_fullStr Deformable Liposomal Hydrogel for Dermal and Transdermal Delivery of Meloxicam
title_full_unstemmed Deformable Liposomal Hydrogel for Dermal and Transdermal Delivery of Meloxicam
title_short Deformable Liposomal Hydrogel for Dermal and Transdermal Delivery of Meloxicam
title_sort deformable liposomal hydrogel for dermal and transdermal delivery of meloxicam
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700092/
https://www.ncbi.nlm.nih.gov/pubmed/33262590
http://dx.doi.org/10.2147/IJN.S274954
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