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Utility of Blood Parameters to Detect Complications during Long-Term Follow-Up in Patients with Diabetic Foot Osteomyelitis

The evidence is still unclear regarding the role of blood parameters in detecting complications in patients who suffer from diabetic foot osteomyelitis (DFO). In this study, the aim was to identify the capacity of different blood parameters in the diagnosis and prediction of the onset of complicatio...

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Autores principales: Tardáguila-García, Aroa, García Álvarez, Yolanda, García-Morales, Esther, Álvaro-Afonso, Francisco Javier, Sanz-Corbalán, Irene, Lázaro-Martínez, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700132/
https://www.ncbi.nlm.nih.gov/pubmed/33266483
http://dx.doi.org/10.3390/jcm9113768
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author Tardáguila-García, Aroa
García Álvarez, Yolanda
García-Morales, Esther
Álvaro-Afonso, Francisco Javier
Sanz-Corbalán, Irene
Lázaro-Martínez, José Luis
author_facet Tardáguila-García, Aroa
García Álvarez, Yolanda
García-Morales, Esther
Álvaro-Afonso, Francisco Javier
Sanz-Corbalán, Irene
Lázaro-Martínez, José Luis
author_sort Tardáguila-García, Aroa
collection PubMed
description The evidence is still unclear regarding the role of blood parameters in detecting complications in patients who suffer from diabetic foot osteomyelitis (DFO). In this study, the aim was to identify the capacity of different blood parameters in the diagnosis and prediction of the onset of complications. A cross-sectional prospective study was carried out with 116 DFO patients. The following blood parameters were evaluated during 1 year of follow-up: leukocytes, neutrophils, lymphocytes, monocytes, eosinophils, basophils, erythrocyte sedimentation rate (ESR), glycemia, glycosylated hemoglobin, C-reactive protein (CRP), alkaline phosphatase, albumin, and creatinine. Complication events were assessed for each participant during the study period. We investigated the association between blood parameter values and the onset of complication events by conducting a receiver operating characteristic curve analysis. Eighty-five (73.3%) patients developed complications. Regarding blood parameters, higher values of lymphocytes and albumin were predictive factors at the 12-month follow-up once the ulcer had healed. Higher values of ESR had predictive and diagnostic value for the onset of complication events, and higher values of CRP and hyperglycemia were diagnostic factors since they were elevated during the occurrence of an event. In conclusion, after suffering from DFO, the elevation of lymphocytes, ESR, CRP, albumin, and glycemia could be useful in detecting and diagnosing patients who are likely to develop a complication. Serial blood tests are a useful tool for early detection by healthcare professionals to prevent complications.
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spelling pubmed-77001322020-11-30 Utility of Blood Parameters to Detect Complications during Long-Term Follow-Up in Patients with Diabetic Foot Osteomyelitis Tardáguila-García, Aroa García Álvarez, Yolanda García-Morales, Esther Álvaro-Afonso, Francisco Javier Sanz-Corbalán, Irene Lázaro-Martínez, José Luis J Clin Med Article The evidence is still unclear regarding the role of blood parameters in detecting complications in patients who suffer from diabetic foot osteomyelitis (DFO). In this study, the aim was to identify the capacity of different blood parameters in the diagnosis and prediction of the onset of complications. A cross-sectional prospective study was carried out with 116 DFO patients. The following blood parameters were evaluated during 1 year of follow-up: leukocytes, neutrophils, lymphocytes, monocytes, eosinophils, basophils, erythrocyte sedimentation rate (ESR), glycemia, glycosylated hemoglobin, C-reactive protein (CRP), alkaline phosphatase, albumin, and creatinine. Complication events were assessed for each participant during the study period. We investigated the association between blood parameter values and the onset of complication events by conducting a receiver operating characteristic curve analysis. Eighty-five (73.3%) patients developed complications. Regarding blood parameters, higher values of lymphocytes and albumin were predictive factors at the 12-month follow-up once the ulcer had healed. Higher values of ESR had predictive and diagnostic value for the onset of complication events, and higher values of CRP and hyperglycemia were diagnostic factors since they were elevated during the occurrence of an event. In conclusion, after suffering from DFO, the elevation of lymphocytes, ESR, CRP, albumin, and glycemia could be useful in detecting and diagnosing patients who are likely to develop a complication. Serial blood tests are a useful tool for early detection by healthcare professionals to prevent complications. MDPI 2020-11-22 /pmc/articles/PMC7700132/ /pubmed/33266483 http://dx.doi.org/10.3390/jcm9113768 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tardáguila-García, Aroa
García Álvarez, Yolanda
García-Morales, Esther
Álvaro-Afonso, Francisco Javier
Sanz-Corbalán, Irene
Lázaro-Martínez, José Luis
Utility of Blood Parameters to Detect Complications during Long-Term Follow-Up in Patients with Diabetic Foot Osteomyelitis
title Utility of Blood Parameters to Detect Complications during Long-Term Follow-Up in Patients with Diabetic Foot Osteomyelitis
title_full Utility of Blood Parameters to Detect Complications during Long-Term Follow-Up in Patients with Diabetic Foot Osteomyelitis
title_fullStr Utility of Blood Parameters to Detect Complications during Long-Term Follow-Up in Patients with Diabetic Foot Osteomyelitis
title_full_unstemmed Utility of Blood Parameters to Detect Complications during Long-Term Follow-Up in Patients with Diabetic Foot Osteomyelitis
title_short Utility of Blood Parameters to Detect Complications during Long-Term Follow-Up in Patients with Diabetic Foot Osteomyelitis
title_sort utility of blood parameters to detect complications during long-term follow-up in patients with diabetic foot osteomyelitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700132/
https://www.ncbi.nlm.nih.gov/pubmed/33266483
http://dx.doi.org/10.3390/jcm9113768
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