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Application-Oriented Marine Isomerases in Biocatalysis

The class EC 5.xx, a group of enzymes that interconvert optical, geometric, or positional isomers are interesting biocatalysts for the synthesis of pharmaceuticals and pharmaceutical intermediates. This class, named “isomerases,” can transform cheap biomolecules into expensive isomers with suitable...

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Detalles Bibliográficos
Autor principal: Trincone, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700177/
https://www.ncbi.nlm.nih.gov/pubmed/33233366
http://dx.doi.org/10.3390/md18110580
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author Trincone, Antonio
author_facet Trincone, Antonio
author_sort Trincone, Antonio
collection PubMed
description The class EC 5.xx, a group of enzymes that interconvert optical, geometric, or positional isomers are interesting biocatalysts for the synthesis of pharmaceuticals and pharmaceutical intermediates. This class, named “isomerases,” can transform cheap biomolecules into expensive isomers with suitable stereochemistry useful in synthetic medicinal chemistry, and interesting cases of production of l-ribose, d-psicose, lactulose, and d-phenylalanine are known. However, in two published reports about potential biocatalysts of marine origin, isomerases are hardly mentioned. Therefore, it is of interest to deepen the knowledge of these biocatalysts from the marine environment with this specialized in-depth analysis conducted using a literature search without time limit constraints. In this review, the focus is dedicated mainly to example applications in biocatalysis that are not numerous confirming the general view previously reported. However, from this overall literature analysis, curiosity-driven scientific interest for marine isomerases seems to have been long-standing. However, the major fields in which application examples are framed are placed at the cutting edge of current biotechnological development. Since these enzymes can offer properties of industrial interest, this will act as a promoter for future studies of marine-originating isomerases in applied biocatalysis.
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spelling pubmed-77001772020-11-30 Application-Oriented Marine Isomerases in Biocatalysis Trincone, Antonio Mar Drugs Review The class EC 5.xx, a group of enzymes that interconvert optical, geometric, or positional isomers are interesting biocatalysts for the synthesis of pharmaceuticals and pharmaceutical intermediates. This class, named “isomerases,” can transform cheap biomolecules into expensive isomers with suitable stereochemistry useful in synthetic medicinal chemistry, and interesting cases of production of l-ribose, d-psicose, lactulose, and d-phenylalanine are known. However, in two published reports about potential biocatalysts of marine origin, isomerases are hardly mentioned. Therefore, it is of interest to deepen the knowledge of these biocatalysts from the marine environment with this specialized in-depth analysis conducted using a literature search without time limit constraints. In this review, the focus is dedicated mainly to example applications in biocatalysis that are not numerous confirming the general view previously reported. However, from this overall literature analysis, curiosity-driven scientific interest for marine isomerases seems to have been long-standing. However, the major fields in which application examples are framed are placed at the cutting edge of current biotechnological development. Since these enzymes can offer properties of industrial interest, this will act as a promoter for future studies of marine-originating isomerases in applied biocatalysis. MDPI 2020-11-21 /pmc/articles/PMC7700177/ /pubmed/33233366 http://dx.doi.org/10.3390/md18110580 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Trincone, Antonio
Application-Oriented Marine Isomerases in Biocatalysis
title Application-Oriented Marine Isomerases in Biocatalysis
title_full Application-Oriented Marine Isomerases in Biocatalysis
title_fullStr Application-Oriented Marine Isomerases in Biocatalysis
title_full_unstemmed Application-Oriented Marine Isomerases in Biocatalysis
title_short Application-Oriented Marine Isomerases in Biocatalysis
title_sort application-oriented marine isomerases in biocatalysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700177/
https://www.ncbi.nlm.nih.gov/pubmed/33233366
http://dx.doi.org/10.3390/md18110580
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