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Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study

Polyamines (including putrescine, spermidine, and spermine) are small, cationic molecules that are necessary for cell proliferation and differentiation. Few studies have examined the association of dietary polyamines intake with colorectal cancer risk. The aim of this study was to evaluate total pol...

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Autores principales: Huang, Chu-Yi, Fang, Yu-Jing, Abulimiti, Alinuer, Yang, Xia, Li, Lei, Liu, Kai-Yan, Zhang, Xin, Feng, Xiao-Li, Chen, Yu-Ming, Zhang, Cai-Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700244/
https://www.ncbi.nlm.nih.gov/pubmed/33266410
http://dx.doi.org/10.3390/nu12113575
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author Huang, Chu-Yi
Fang, Yu-Jing
Abulimiti, Alinuer
Yang, Xia
Li, Lei
Liu, Kai-Yan
Zhang, Xin
Feng, Xiao-Li
Chen, Yu-Ming
Zhang, Cai-Xia
author_facet Huang, Chu-Yi
Fang, Yu-Jing
Abulimiti, Alinuer
Yang, Xia
Li, Lei
Liu, Kai-Yan
Zhang, Xin
Feng, Xiao-Li
Chen, Yu-Ming
Zhang, Cai-Xia
author_sort Huang, Chu-Yi
collection PubMed
description Polyamines (including putrescine, spermidine, and spermine) are small, cationic molecules that are necessary for cell proliferation and differentiation. Few studies have examined the association of dietary polyamines intake with colorectal cancer risk. The aim of this study was to evaluate total polyamines, putrescine, spermidine, and spermine intake in relation to colorectal cancer risk in China. In total, 2502 colorectal cancer cases and 2538 age-(5-year interval) and sex-matched controls were recruited from July 2010 to April 2019. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by multivariable unconditional logistic regression after adjustment for various potential confounding factors. Higher intake of total polyamine, putrescine and spermidine was significantly associated with reduced risk of colorectal cancer. The adjusted ORs for the highest compared with the lowest quartile of intake were 0.60 (95% CI 0.50, 0.72; P(trend) < 0.001) for total polyamines, 0.35 (95% CI 0.29, 0.43; P(trend) < 0.001) for putrescine and 0.79 (95% CI 0.66, 0.95; P(trend) = 0.001) for spermidine, respectively. However, higher intake of spermine was associated with increased risk of colorectal cancer, with an adjusted OR of 1.58 (95% CI 1.29, 1.93; P(trend) < 0.001). This data indicate that higher intake of total polyamines, putrescine and spermidine, as well as lower intake of spermine, is associated with a decreased risk of colorectal cancer.
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spelling pubmed-77002442020-11-30 Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study Huang, Chu-Yi Fang, Yu-Jing Abulimiti, Alinuer Yang, Xia Li, Lei Liu, Kai-Yan Zhang, Xin Feng, Xiao-Li Chen, Yu-Ming Zhang, Cai-Xia Nutrients Article Polyamines (including putrescine, spermidine, and spermine) are small, cationic molecules that are necessary for cell proliferation and differentiation. Few studies have examined the association of dietary polyamines intake with colorectal cancer risk. The aim of this study was to evaluate total polyamines, putrescine, spermidine, and spermine intake in relation to colorectal cancer risk in China. In total, 2502 colorectal cancer cases and 2538 age-(5-year interval) and sex-matched controls were recruited from July 2010 to April 2019. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by multivariable unconditional logistic regression after adjustment for various potential confounding factors. Higher intake of total polyamine, putrescine and spermidine was significantly associated with reduced risk of colorectal cancer. The adjusted ORs for the highest compared with the lowest quartile of intake were 0.60 (95% CI 0.50, 0.72; P(trend) < 0.001) for total polyamines, 0.35 (95% CI 0.29, 0.43; P(trend) < 0.001) for putrescine and 0.79 (95% CI 0.66, 0.95; P(trend) = 0.001) for spermidine, respectively. However, higher intake of spermine was associated with increased risk of colorectal cancer, with an adjusted OR of 1.58 (95% CI 1.29, 1.93; P(trend) < 0.001). This data indicate that higher intake of total polyamines, putrescine and spermidine, as well as lower intake of spermine, is associated with a decreased risk of colorectal cancer. MDPI 2020-11-22 /pmc/articles/PMC7700244/ /pubmed/33266410 http://dx.doi.org/10.3390/nu12113575 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Chu-Yi
Fang, Yu-Jing
Abulimiti, Alinuer
Yang, Xia
Li, Lei
Liu, Kai-Yan
Zhang, Xin
Feng, Xiao-Li
Chen, Yu-Ming
Zhang, Cai-Xia
Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study
title Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study
title_full Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study
title_fullStr Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study
title_full_unstemmed Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study
title_short Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study
title_sort dietary polyamines intake and risk of colorectal cancer: a case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700244/
https://www.ncbi.nlm.nih.gov/pubmed/33266410
http://dx.doi.org/10.3390/nu12113575
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