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Fully Automated Breast Density Segmentation and Classification Using Deep Learning

Breast density estimation with visual evaluation is still challenging due to low contrast and significant fluctuations in the mammograms’ fatty tissue background. The primary key to breast density classification is to detect the dense tissues in the mammographic images correctly. Many methods have b...

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Autores principales: Saffari, Nasibeh, Rashwan, Hatem A., Abdel-Nasser, Mohamed, Kumar Singh, Vivek, Arenas, Meritxell, Mangina, Eleni, Herrera, Blas, Puig, Domenec
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700286/
https://www.ncbi.nlm.nih.gov/pubmed/33238512
http://dx.doi.org/10.3390/diagnostics10110988
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author Saffari, Nasibeh
Rashwan, Hatem A.
Abdel-Nasser, Mohamed
Kumar Singh, Vivek
Arenas, Meritxell
Mangina, Eleni
Herrera, Blas
Puig, Domenec
author_facet Saffari, Nasibeh
Rashwan, Hatem A.
Abdel-Nasser, Mohamed
Kumar Singh, Vivek
Arenas, Meritxell
Mangina, Eleni
Herrera, Blas
Puig, Domenec
author_sort Saffari, Nasibeh
collection PubMed
description Breast density estimation with visual evaluation is still challenging due to low contrast and significant fluctuations in the mammograms’ fatty tissue background. The primary key to breast density classification is to detect the dense tissues in the mammographic images correctly. Many methods have been proposed for breast density estimation; nevertheless, most of them are not fully automated. Besides, they have been badly affected by low signal-to-noise ratio and variability of density in appearance and texture. This study intends to develop a fully automated and digitalized breast tissue segmentation and classification using advanced deep learning techniques. The conditional Generative Adversarial Networks (cGAN) network is applied to segment the dense tissues in mammograms. To have a complete system for breast density classification, we propose a Convolutional Neural Network (CNN) to classify mammograms based on the standardization of Breast Imaging-Reporting and Data System (BI-RADS). The classification network is fed by the segmented masks of dense tissues generated by the cGAN network. For screening mammography, 410 images of 115 patients from the INbreast dataset were used. The proposed framework can segment the dense regions with an accuracy, Dice coefficient, Jaccard index of 98%, 88%, and 78%, respectively. Furthermore, we obtained precision, sensitivity, and specificity of 97.85%, 97.85%, and 99.28%, respectively, for breast density classification. This study’s findings are promising and show that the proposed deep learning-based techniques can produce a clinically useful computer-aided tool for breast density analysis by digital mammography.
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spelling pubmed-77002862020-11-30 Fully Automated Breast Density Segmentation and Classification Using Deep Learning Saffari, Nasibeh Rashwan, Hatem A. Abdel-Nasser, Mohamed Kumar Singh, Vivek Arenas, Meritxell Mangina, Eleni Herrera, Blas Puig, Domenec Diagnostics (Basel) Article Breast density estimation with visual evaluation is still challenging due to low contrast and significant fluctuations in the mammograms’ fatty tissue background. The primary key to breast density classification is to detect the dense tissues in the mammographic images correctly. Many methods have been proposed for breast density estimation; nevertheless, most of them are not fully automated. Besides, they have been badly affected by low signal-to-noise ratio and variability of density in appearance and texture. This study intends to develop a fully automated and digitalized breast tissue segmentation and classification using advanced deep learning techniques. The conditional Generative Adversarial Networks (cGAN) network is applied to segment the dense tissues in mammograms. To have a complete system for breast density classification, we propose a Convolutional Neural Network (CNN) to classify mammograms based on the standardization of Breast Imaging-Reporting and Data System (BI-RADS). The classification network is fed by the segmented masks of dense tissues generated by the cGAN network. For screening mammography, 410 images of 115 patients from the INbreast dataset were used. The proposed framework can segment the dense regions with an accuracy, Dice coefficient, Jaccard index of 98%, 88%, and 78%, respectively. Furthermore, we obtained precision, sensitivity, and specificity of 97.85%, 97.85%, and 99.28%, respectively, for breast density classification. This study’s findings are promising and show that the proposed deep learning-based techniques can produce a clinically useful computer-aided tool for breast density analysis by digital mammography. MDPI 2020-11-23 /pmc/articles/PMC7700286/ /pubmed/33238512 http://dx.doi.org/10.3390/diagnostics10110988 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Saffari, Nasibeh
Rashwan, Hatem A.
Abdel-Nasser, Mohamed
Kumar Singh, Vivek
Arenas, Meritxell
Mangina, Eleni
Herrera, Blas
Puig, Domenec
Fully Automated Breast Density Segmentation and Classification Using Deep Learning
title Fully Automated Breast Density Segmentation and Classification Using Deep Learning
title_full Fully Automated Breast Density Segmentation and Classification Using Deep Learning
title_fullStr Fully Automated Breast Density Segmentation and Classification Using Deep Learning
title_full_unstemmed Fully Automated Breast Density Segmentation and Classification Using Deep Learning
title_short Fully Automated Breast Density Segmentation and Classification Using Deep Learning
title_sort fully automated breast density segmentation and classification using deep learning
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700286/
https://www.ncbi.nlm.nih.gov/pubmed/33238512
http://dx.doi.org/10.3390/diagnostics10110988
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