A Perspective on Organoids for Virology Research

Animal models and cell lines are invaluable for virology research and host–pathogen interaction studies. However, it is increasingly evident that these models are not sufficient to fully understand human viral diseases. With the advent of three-dimensional organotypic cultures, it is now possible to...

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Detalles Bibliográficos
Autores principales: Sridhar, Adithya, Simmini, Salvatore, Ribeiro, Carla M. S., Tapparel, Caroline, Evers, Melvin M., Pajkrt, Dasja, Wolthers, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700289/
https://www.ncbi.nlm.nih.gov/pubmed/33238561
http://dx.doi.org/10.3390/v12111341
Descripción
Sumario:Animal models and cell lines are invaluable for virology research and host–pathogen interaction studies. However, it is increasingly evident that these models are not sufficient to fully understand human viral diseases. With the advent of three-dimensional organotypic cultures, it is now possible to study viral infections in the human context. This perspective explores the potential of these organotypic cultures, also known as organoids, for virology research, antiviral testing, and shaping the virology landscape.

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