A Perspective on Organoids for Virology Research

Animal models and cell lines are invaluable for virology research and host–pathogen interaction studies. However, it is increasingly evident that these models are not sufficient to fully understand human viral diseases. With the advent of three-dimensional organotypic cultures, it is now possible to...

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Autores principales: Sridhar, Adithya, Simmini, Salvatore, Ribeiro, Carla M. S., Tapparel, Caroline, Evers, Melvin M., Pajkrt, Dasja, Wolthers, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700289/
https://www.ncbi.nlm.nih.gov/pubmed/33238561
http://dx.doi.org/10.3390/v12111341
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author Sridhar, Adithya
Simmini, Salvatore
Ribeiro, Carla M. S.
Tapparel, Caroline
Evers, Melvin M.
Pajkrt, Dasja
Wolthers, Katja
author_facet Sridhar, Adithya
Simmini, Salvatore
Ribeiro, Carla M. S.
Tapparel, Caroline
Evers, Melvin M.
Pajkrt, Dasja
Wolthers, Katja
author_sort Sridhar, Adithya
collection PubMed
description Animal models and cell lines are invaluable for virology research and host–pathogen interaction studies. However, it is increasingly evident that these models are not sufficient to fully understand human viral diseases. With the advent of three-dimensional organotypic cultures, it is now possible to study viral infections in the human context. This perspective explores the potential of these organotypic cultures, also known as organoids, for virology research, antiviral testing, and shaping the virology landscape.
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spelling pubmed-77002892020-11-30 A Perspective on Organoids for Virology Research Sridhar, Adithya Simmini, Salvatore Ribeiro, Carla M. S. Tapparel, Caroline Evers, Melvin M. Pajkrt, Dasja Wolthers, Katja Viruses Opinion Animal models and cell lines are invaluable for virology research and host–pathogen interaction studies. However, it is increasingly evident that these models are not sufficient to fully understand human viral diseases. With the advent of three-dimensional organotypic cultures, it is now possible to study viral infections in the human context. This perspective explores the potential of these organotypic cultures, also known as organoids, for virology research, antiviral testing, and shaping the virology landscape. MDPI 2020-11-23 /pmc/articles/PMC7700289/ /pubmed/33238561 http://dx.doi.org/10.3390/v12111341 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
Sridhar, Adithya
Simmini, Salvatore
Ribeiro, Carla M. S.
Tapparel, Caroline
Evers, Melvin M.
Pajkrt, Dasja
Wolthers, Katja
A Perspective on Organoids for Virology Research
title A Perspective on Organoids for Virology Research
title_full A Perspective on Organoids for Virology Research
title_fullStr A Perspective on Organoids for Virology Research
title_full_unstemmed A Perspective on Organoids for Virology Research
title_short A Perspective on Organoids for Virology Research
title_sort perspective on organoids for virology research
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700289/
https://www.ncbi.nlm.nih.gov/pubmed/33238561
http://dx.doi.org/10.3390/v12111341
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