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Anti-Adipogenic Effect of Theabrownin Is Mediated by Bile Acid Alternative Synthesis via Gut Microbiota Remodeling
Theabrownin is one of the most bioactive compounds in Pu-erh tea. Our previous study revealed that the hypocholesterolemic effect of theabrownin was mediated by the modulation of bile salt hydrolase (BSH)-enriched gut microbiota and bile acid metabolism. In this study, we demonstrated that theabrown...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700314/ https://www.ncbi.nlm.nih.gov/pubmed/33238385 http://dx.doi.org/10.3390/metabo10110475 |
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author | Kuang, Junliang Zheng, Xiaojiao Huang, Fengjie Wang, Shouli Li, Mengci Zhao, Mingliang Sang, Chao Ge, Kun Li, Yitao Li, Jiufeng Rajani, Cynthia Ma, Xiaohui Zhou, Shuiping Zhao, Aihua Jia, Wei |
author_facet | Kuang, Junliang Zheng, Xiaojiao Huang, Fengjie Wang, Shouli Li, Mengci Zhao, Mingliang Sang, Chao Ge, Kun Li, Yitao Li, Jiufeng Rajani, Cynthia Ma, Xiaohui Zhou, Shuiping Zhao, Aihua Jia, Wei |
author_sort | Kuang, Junliang |
collection | PubMed |
description | Theabrownin is one of the most bioactive compounds in Pu-erh tea. Our previous study revealed that the hypocholesterolemic effect of theabrownin was mediated by the modulation of bile salt hydrolase (BSH)-enriched gut microbiota and bile acid metabolism. In this study, we demonstrated that theabrownin ameliorated high-fat-diet (HFD)-induced obesity by modifying gut microbiota, especially those with 7α-dehydroxylation on the species level, and these changed microbes were positively correlated with secondary bile acid (BA) metabolism. Thus, altered intestinal BAs resulted in shifting bile acid biosynthesis from the classic to the alternative pathway. This shift changed the BA pool by increasing non-12α-hydroxylated-BAs (non-12OH-BAs) and decreasing 12α-hydroxylated BAs (12OH-BAs), which improved energy metabolism in white and brown adipose tissue. This study showed that theabrownin was a potential therapeutic modality for obesity and other metabolic disorders via gut microbiota-driven bile acid alternative synthesis. |
format | Online Article Text |
id | pubmed-7700314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77003142020-11-30 Anti-Adipogenic Effect of Theabrownin Is Mediated by Bile Acid Alternative Synthesis via Gut Microbiota Remodeling Kuang, Junliang Zheng, Xiaojiao Huang, Fengjie Wang, Shouli Li, Mengci Zhao, Mingliang Sang, Chao Ge, Kun Li, Yitao Li, Jiufeng Rajani, Cynthia Ma, Xiaohui Zhou, Shuiping Zhao, Aihua Jia, Wei Metabolites Article Theabrownin is one of the most bioactive compounds in Pu-erh tea. Our previous study revealed that the hypocholesterolemic effect of theabrownin was mediated by the modulation of bile salt hydrolase (BSH)-enriched gut microbiota and bile acid metabolism. In this study, we demonstrated that theabrownin ameliorated high-fat-diet (HFD)-induced obesity by modifying gut microbiota, especially those with 7α-dehydroxylation on the species level, and these changed microbes were positively correlated with secondary bile acid (BA) metabolism. Thus, altered intestinal BAs resulted in shifting bile acid biosynthesis from the classic to the alternative pathway. This shift changed the BA pool by increasing non-12α-hydroxylated-BAs (non-12OH-BAs) and decreasing 12α-hydroxylated BAs (12OH-BAs), which improved energy metabolism in white and brown adipose tissue. This study showed that theabrownin was a potential therapeutic modality for obesity and other metabolic disorders via gut microbiota-driven bile acid alternative synthesis. MDPI 2020-11-23 /pmc/articles/PMC7700314/ /pubmed/33238385 http://dx.doi.org/10.3390/metabo10110475 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kuang, Junliang Zheng, Xiaojiao Huang, Fengjie Wang, Shouli Li, Mengci Zhao, Mingliang Sang, Chao Ge, Kun Li, Yitao Li, Jiufeng Rajani, Cynthia Ma, Xiaohui Zhou, Shuiping Zhao, Aihua Jia, Wei Anti-Adipogenic Effect of Theabrownin Is Mediated by Bile Acid Alternative Synthesis via Gut Microbiota Remodeling |
title | Anti-Adipogenic Effect of Theabrownin Is Mediated by Bile Acid Alternative Synthesis via Gut Microbiota Remodeling |
title_full | Anti-Adipogenic Effect of Theabrownin Is Mediated by Bile Acid Alternative Synthesis via Gut Microbiota Remodeling |
title_fullStr | Anti-Adipogenic Effect of Theabrownin Is Mediated by Bile Acid Alternative Synthesis via Gut Microbiota Remodeling |
title_full_unstemmed | Anti-Adipogenic Effect of Theabrownin Is Mediated by Bile Acid Alternative Synthesis via Gut Microbiota Remodeling |
title_short | Anti-Adipogenic Effect of Theabrownin Is Mediated by Bile Acid Alternative Synthesis via Gut Microbiota Remodeling |
title_sort | anti-adipogenic effect of theabrownin is mediated by bile acid alternative synthesis via gut microbiota remodeling |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700314/ https://www.ncbi.nlm.nih.gov/pubmed/33238385 http://dx.doi.org/10.3390/metabo10110475 |
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