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Notch Signaling Regulation in Autoinflammatory Diseases

Notch pathway is a highly conserved intracellular signaling route that modulates a vast variety of cellular processes including proliferation, differentiation, migration, cell fate and death. Recently, the presence of a strict crosstalk between Notch signaling and inflammation has been described, al...

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Autores principales: Gratton, Rossella, Tricarico, Paola Maura, d’Adamo, Adamo Pio, Bianco, Anna Monica, Moura, Ronald, Agrelli, Almerinda, Brandão, Lucas, Zupin, Luisa, Crovella, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700323/
https://www.ncbi.nlm.nih.gov/pubmed/33238371
http://dx.doi.org/10.3390/ijms21228847
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author Gratton, Rossella
Tricarico, Paola Maura
d’Adamo, Adamo Pio
Bianco, Anna Monica
Moura, Ronald
Agrelli, Almerinda
Brandão, Lucas
Zupin, Luisa
Crovella, Sergio
author_facet Gratton, Rossella
Tricarico, Paola Maura
d’Adamo, Adamo Pio
Bianco, Anna Monica
Moura, Ronald
Agrelli, Almerinda
Brandão, Lucas
Zupin, Luisa
Crovella, Sergio
author_sort Gratton, Rossella
collection PubMed
description Notch pathway is a highly conserved intracellular signaling route that modulates a vast variety of cellular processes including proliferation, differentiation, migration, cell fate and death. Recently, the presence of a strict crosstalk between Notch signaling and inflammation has been described, although the precise molecular mechanisms underlying this interplay have not yet been fully unravelled. Disruptions in Notch cascade, due both to direct mutations and/or to an altered regulation in the core components of Notch signaling, might lead to hypo- or hyperactivation of Notch target genes and signaling molecules, ultimately contributing to the onset of autoinflammatory diseases. To date, alterations in Notch signaling have been reported as associated with three autoinflammatory disorders, therefore, suggesting a possible role of Notch in the pathogenesis of the following diseases: hidradenitis suppurativa (HS), Behçet disease (BD), and giant cell arteritis (GCA). In this review, we aim at better characterizing the interplay between Notch and autoinflammatory diseases, trying to identify the role of this signaling route in the context of these disorders.
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spelling pubmed-77003232020-11-30 Notch Signaling Regulation in Autoinflammatory Diseases Gratton, Rossella Tricarico, Paola Maura d’Adamo, Adamo Pio Bianco, Anna Monica Moura, Ronald Agrelli, Almerinda Brandão, Lucas Zupin, Luisa Crovella, Sergio Int J Mol Sci Review Notch pathway is a highly conserved intracellular signaling route that modulates a vast variety of cellular processes including proliferation, differentiation, migration, cell fate and death. Recently, the presence of a strict crosstalk between Notch signaling and inflammation has been described, although the precise molecular mechanisms underlying this interplay have not yet been fully unravelled. Disruptions in Notch cascade, due both to direct mutations and/or to an altered regulation in the core components of Notch signaling, might lead to hypo- or hyperactivation of Notch target genes and signaling molecules, ultimately contributing to the onset of autoinflammatory diseases. To date, alterations in Notch signaling have been reported as associated with three autoinflammatory disorders, therefore, suggesting a possible role of Notch in the pathogenesis of the following diseases: hidradenitis suppurativa (HS), Behçet disease (BD), and giant cell arteritis (GCA). In this review, we aim at better characterizing the interplay between Notch and autoinflammatory diseases, trying to identify the role of this signaling route in the context of these disorders. MDPI 2020-11-23 /pmc/articles/PMC7700323/ /pubmed/33238371 http://dx.doi.org/10.3390/ijms21228847 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gratton, Rossella
Tricarico, Paola Maura
d’Adamo, Adamo Pio
Bianco, Anna Monica
Moura, Ronald
Agrelli, Almerinda
Brandão, Lucas
Zupin, Luisa
Crovella, Sergio
Notch Signaling Regulation in Autoinflammatory Diseases
title Notch Signaling Regulation in Autoinflammatory Diseases
title_full Notch Signaling Regulation in Autoinflammatory Diseases
title_fullStr Notch Signaling Regulation in Autoinflammatory Diseases
title_full_unstemmed Notch Signaling Regulation in Autoinflammatory Diseases
title_short Notch Signaling Regulation in Autoinflammatory Diseases
title_sort notch signaling regulation in autoinflammatory diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700323/
https://www.ncbi.nlm.nih.gov/pubmed/33238371
http://dx.doi.org/10.3390/ijms21228847
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