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Notch Signaling Regulation in Autoinflammatory Diseases
Notch pathway is a highly conserved intracellular signaling route that modulates a vast variety of cellular processes including proliferation, differentiation, migration, cell fate and death. Recently, the presence of a strict crosstalk between Notch signaling and inflammation has been described, al...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700323/ https://www.ncbi.nlm.nih.gov/pubmed/33238371 http://dx.doi.org/10.3390/ijms21228847 |
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author | Gratton, Rossella Tricarico, Paola Maura d’Adamo, Adamo Pio Bianco, Anna Monica Moura, Ronald Agrelli, Almerinda Brandão, Lucas Zupin, Luisa Crovella, Sergio |
author_facet | Gratton, Rossella Tricarico, Paola Maura d’Adamo, Adamo Pio Bianco, Anna Monica Moura, Ronald Agrelli, Almerinda Brandão, Lucas Zupin, Luisa Crovella, Sergio |
author_sort | Gratton, Rossella |
collection | PubMed |
description | Notch pathway is a highly conserved intracellular signaling route that modulates a vast variety of cellular processes including proliferation, differentiation, migration, cell fate and death. Recently, the presence of a strict crosstalk between Notch signaling and inflammation has been described, although the precise molecular mechanisms underlying this interplay have not yet been fully unravelled. Disruptions in Notch cascade, due both to direct mutations and/or to an altered regulation in the core components of Notch signaling, might lead to hypo- or hyperactivation of Notch target genes and signaling molecules, ultimately contributing to the onset of autoinflammatory diseases. To date, alterations in Notch signaling have been reported as associated with three autoinflammatory disorders, therefore, suggesting a possible role of Notch in the pathogenesis of the following diseases: hidradenitis suppurativa (HS), Behçet disease (BD), and giant cell arteritis (GCA). In this review, we aim at better characterizing the interplay between Notch and autoinflammatory diseases, trying to identify the role of this signaling route in the context of these disorders. |
format | Online Article Text |
id | pubmed-7700323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77003232020-11-30 Notch Signaling Regulation in Autoinflammatory Diseases Gratton, Rossella Tricarico, Paola Maura d’Adamo, Adamo Pio Bianco, Anna Monica Moura, Ronald Agrelli, Almerinda Brandão, Lucas Zupin, Luisa Crovella, Sergio Int J Mol Sci Review Notch pathway is a highly conserved intracellular signaling route that modulates a vast variety of cellular processes including proliferation, differentiation, migration, cell fate and death. Recently, the presence of a strict crosstalk between Notch signaling and inflammation has been described, although the precise molecular mechanisms underlying this interplay have not yet been fully unravelled. Disruptions in Notch cascade, due both to direct mutations and/or to an altered regulation in the core components of Notch signaling, might lead to hypo- or hyperactivation of Notch target genes and signaling molecules, ultimately contributing to the onset of autoinflammatory diseases. To date, alterations in Notch signaling have been reported as associated with three autoinflammatory disorders, therefore, suggesting a possible role of Notch in the pathogenesis of the following diseases: hidradenitis suppurativa (HS), Behçet disease (BD), and giant cell arteritis (GCA). In this review, we aim at better characterizing the interplay between Notch and autoinflammatory diseases, trying to identify the role of this signaling route in the context of these disorders. MDPI 2020-11-23 /pmc/articles/PMC7700323/ /pubmed/33238371 http://dx.doi.org/10.3390/ijms21228847 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gratton, Rossella Tricarico, Paola Maura d’Adamo, Adamo Pio Bianco, Anna Monica Moura, Ronald Agrelli, Almerinda Brandão, Lucas Zupin, Luisa Crovella, Sergio Notch Signaling Regulation in Autoinflammatory Diseases |
title | Notch Signaling Regulation in Autoinflammatory Diseases |
title_full | Notch Signaling Regulation in Autoinflammatory Diseases |
title_fullStr | Notch Signaling Regulation in Autoinflammatory Diseases |
title_full_unstemmed | Notch Signaling Regulation in Autoinflammatory Diseases |
title_short | Notch Signaling Regulation in Autoinflammatory Diseases |
title_sort | notch signaling regulation in autoinflammatory diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700323/ https://www.ncbi.nlm.nih.gov/pubmed/33238371 http://dx.doi.org/10.3390/ijms21228847 |
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