Cargando…

The Aging Stress Response and Its Implication for AMD Pathogenesis

Aging induces several stress response pathways to counterbalance detrimental changes associated with this process. These pathways include nutrient signaling, proteostasis, mitochondrial quality control and DNA damage response. At the cellular level, these pathways are controlled by evolutionarily co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blasiak, Janusz, Pawlowska, Elzbieta, Sobczuk, Anna, Szczepanska, Joanna, Kaarniranta, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700335/ https://www.ncbi.nlm.nih.gov/pubmed/33266495 http://dx.doi.org/10.3390/ijms21228840

Ejemplares similares

DICER1 in the Pathogenesis of Age-related Macular Degeneration (AMD) - Alu RNA Accumulation versus miRNA Dysregulation
por: Kaarniranta, Kai, et al.
Publicado: (2020)

Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD)
por: Kaarniranta, Kai, et al.
Publicado: (2019)

Interplay between Autophagy and the Ubiquitin-Proteasome System and Its Role in the Pathogenesis of Age-Related Macular Degeneration
por: Blasiak, Janusz, et al.
Publicado: (2019)

PGC-1α Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis
por: Kaarniranta, Kai, et al.
Publicado: (2018)

Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond
por: Pawlowska, Elzbieta, et al.
Publicado: (2019)

Potential of Telomerase in Age-Related Macular Degeneration—Involvement of Senescence, DNA Damage Response and Autophagy and a Key Role of PGC-1α
por: Blasiak, Janusz, et al.
Publicado: (2021)

Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD)
por: Tokarz, Paulina, et al.
Publicado: (2013)

Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration
por: Blasiak, Janusz, et al.
Publicado: (2021)

Zinc and Autophagy in Age-Related Macular Degeneration
por: Blasiak, Janusz, et al.
Publicado: (2020)

RIF1 Links Replication Timing with Fork Reactivation and DNA Double-Strand Break Repair
por: Blasiak, Janusz, et al.
Publicado: (2021)

Non-Coding RNAs Regulating Mitochondrial Functions and the Oxidative Stress Response as Putative Targets against Age-Related Macular Degeneration (AMD)
por: Hyttinen, Juha M. T., et al.
Publicado: (2023)

Epigallocatechin-3-Gallate, an Active Green Tea Component to Support Anti-VEGFA Therapy in Wet Age-Related Macular Degeneration
por: Blasiak, Janusz, et al.
Publicado: (2023)

Vitamin D in Triple-Negative and BRCA1-Deficient Breast Cancer—Implications for Pathogenesis and Therapy
por: Blasiak, Janusz, et al.
Publicado: (2020)

An Interplay between Senescence, Apoptosis and Autophagy in Glioblastoma Multiforme—Role in Pathogenesis and Therapeutic Perspective
por: Pawlowska, Elzbieta, et al.
Publicado: (2018)

Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations
por: Pawlowska, Elzbieta, et al.
Publicado: (2019)

Epigenetic Connection of the Calcitonin Gene-Related Peptide and Its Potential in Migraine
por: Fila, Michal, et al.
Publicado: (2022)

DNA2—An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?
por: Pawłowska, Elzbieta, et al.
Publicado: (2017)

Different Aspects of Aging in Migraine
por: Fila, Michal, et al.
Publicado: (2023)

Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?
por: Blasiak, Janusz, et al.
Publicado: (2017)

Autophagy in DNA Damage Response
por: Czarny, Piotr, et al.
Publicado: (2015)

NF-κB-Mediated Inflammation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage. Does Autophagy Play a Role?
por: Pawlowska, Elzbieta, et al.
Publicado: (2018)

The Long Noncoding RNA HOTAIR in Breast Cancer: Does Autophagy Play a Role?
por: Pawłowska, Elżbieta, et al.
Publicado: (2017)

Nutrition in Cancer Therapy in the Elderly—An Epigenetic Connection?
por: Blasiak, Janusz, et al.
Publicado: (2020)

mRNA Trafficking in the Nervous System: A Key Mechanism of the Involvement of Activity-Regulated Cytoskeleton-Associated Protein (Arc) in Synaptic Plasticity
por: Fila, Michal, et al.
Publicado: (2021)

Variability of the Transferrin Receptor 2 Gene in AMD
por: Wysokinski, Daniel, et al.
Publicado: (2014)

Epigenetic Connections of the TRPA1 Ion Channel in Pain Transmission and Neurogenic Inflammation — a Therapeutic Perspective in Migraine?
por: Fila, Michal, et al.
Publicado: (2023)

Kynurenine Pathway of Tryptophan Metabolism in Migraine and Functional Gastrointestinal Disorders
por: Fila, Michal, et al.
Publicado: (2021)

Dexamethasone and 1,25-Dihydroxyvitamin D3 Reduce Oxidative Stress-Related DNA Damage in Differentiating Osteoblasts
por: Pawlowska, Elzbieta, et al.
Publicado: (2014)

Inflammation and its role in age-related macular degeneration
por: Kauppinen, Anu, et al.
Publicado: (2016)

2-Hydroxylethyl methacrylate (HEMA), a tooth restoration component, exerts its genotoxic effects in human gingival fibroblasts trough methacrylic acid, an immediate product of its degradation
por: Szczepanska, Joanna, et al.
Publicado: (2011)

Oxidative Stress, Hypoxia, and Autophagy in the Neovascular Processes of Age-Related Macular Degeneration
por: Blasiak, Janusz, et al.
Publicado: (2014)

Expression of VEGFA‐regulating miRNAs and mortality in wet AMD
por: Blasiak, Janusz, et al.
Publicado: (2019)

Melatonin in Retinal Physiology and Pathology: The Case of Age-Related Macular Degeneration
por: Blasiak, Janusz, et al.
Publicado: (2016)

Mitochondrial and Nuclear DNA Damage and Repair in Age-Related Macular Degeneration
por: Blasiak, Janusz, et al.
Publicado: (2013)

Genetic Variability in DNA Repair Proteins in Age-Related Macular Degeneration
por: Blasiak, Janusz, et al.
Publicado: (2012)

DNA Repair—A Double-Edged Sword in the Genomic Stability of Cancer Cells—The Case of Chronic Myeloid Leukemia
por: Pawlowska, Elzbieta, et al.
Publicado: (2015)

Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration
por: Kaarniranta, Kai, et al.
Publicado: (2016)

Protective effect of chitosan oligosaccharide lactate against DNA double-strand breaks induced by a model methacrylate dental adhesive
por: Szczepanska, Joanna, et al.
Publicado: (2011)

Nucleotide Excision Repair and Vitamin D—Relevance for Skin Cancer Therapy
por: Pawlowska, Elzbieta, et al.
Publicado: (2016)

Role of RUNX2 in Breast Carcinogenesis
por: Wysokinski, Daniel, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_1mvdk52mr1n1mjj85oh6tas33b