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Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis

The involvement of macular preganglionic elements’ function, during the neurodegenerative process of multiple sclerosis (MS), is controversial. In this case-control observational and retrospective study, we assessed multifocal electroretinogram (mfERG) responses from 41 healthy Controls, 41 relapsin...

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Autores principales: Ziccardi, Lucia, Barbano, Lucilla, Boffa, Laura, Albanese, Maria, Nicoletti, Carolina Gabri, Landi, Doriana, Grzybowski, Andrzej, Falsini, Benedetto, Marfia, Girolama Alessandra, Centonze, Diego, Parisi, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700336/
https://www.ncbi.nlm.nih.gov/pubmed/33266435
http://dx.doi.org/10.3390/jcm9113766
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author Ziccardi, Lucia
Barbano, Lucilla
Boffa, Laura
Albanese, Maria
Nicoletti, Carolina Gabri
Landi, Doriana
Grzybowski, Andrzej
Falsini, Benedetto
Marfia, Girolama Alessandra
Centonze, Diego
Parisi, Vincenzo
author_facet Ziccardi, Lucia
Barbano, Lucilla
Boffa, Laura
Albanese, Maria
Nicoletti, Carolina Gabri
Landi, Doriana
Grzybowski, Andrzej
Falsini, Benedetto
Marfia, Girolama Alessandra
Centonze, Diego
Parisi, Vincenzo
author_sort Ziccardi, Lucia
collection PubMed
description The involvement of macular preganglionic elements’ function, during the neurodegenerative process of multiple sclerosis (MS), is controversial. In this case-control observational and retrospective study, we assessed multifocal electroretinogram (mfERG) responses from 41 healthy Controls, 41 relapsing-remitting MS patients without optic neuritis (ON) (MS-noON Group) and 47 MS patients with ON: 27 with full recovery of high-contrast best corrected visual acuity (BCVA) (MS-ON-G Group) and 20 with poor recovery (between 0.2 and 1 LogMAR) of BCVA, (MS-ON-P Group). In the latter Group, Sd-OCT macular volumes and thicknesses of whole and inner and outer retina were measured. MfERG N1 and P1 implicit times (ITs), and N1-P1 response amplitude densities (RADs), were measured from concentric rings (R) with increasing foveal eccentricity: 0–5° (R1), 5–10° (R2), 10–15° (R3), 15–20° (R4), 20–25° (R5), and from retinal sectors (superior, nasal, inferior and temporal) between 0–15° and 0–25°. In the MS-ON-P Group, mean mfERG RADs detected from R1 (0–5°) and from the central nasal sector (0–15°) were significantly reduced (p < 0.01) with respect to those of the Control, MS-noON and MS-ON-G Groups. No other significant differences between Groups for any mfERG parameters were found. All Sd-OCT measurements, apart from the inner retina macular volume in the central 1 mm, were significantly reduced in MS-ON-P patients compared to Controls. The functional impairment in the MS-ON-P Group was associated but not correlated with structural changes of the outer and inner retinal layers in corresponding retinal Areas and Sectors. Our results suggest that in MS, exclusively after ON with poor recovery of BCVA, the neurodegenerative process can induce dysfunctional mechanisms involving photoreceptors and bipolar cells of the fovea and of the more central nasal macular area.
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spelling pubmed-77003362020-11-30 Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis Ziccardi, Lucia Barbano, Lucilla Boffa, Laura Albanese, Maria Nicoletti, Carolina Gabri Landi, Doriana Grzybowski, Andrzej Falsini, Benedetto Marfia, Girolama Alessandra Centonze, Diego Parisi, Vincenzo J Clin Med Article The involvement of macular preganglionic elements’ function, during the neurodegenerative process of multiple sclerosis (MS), is controversial. In this case-control observational and retrospective study, we assessed multifocal electroretinogram (mfERG) responses from 41 healthy Controls, 41 relapsing-remitting MS patients without optic neuritis (ON) (MS-noON Group) and 47 MS patients with ON: 27 with full recovery of high-contrast best corrected visual acuity (BCVA) (MS-ON-G Group) and 20 with poor recovery (between 0.2 and 1 LogMAR) of BCVA, (MS-ON-P Group). In the latter Group, Sd-OCT macular volumes and thicknesses of whole and inner and outer retina were measured. MfERG N1 and P1 implicit times (ITs), and N1-P1 response amplitude densities (RADs), were measured from concentric rings (R) with increasing foveal eccentricity: 0–5° (R1), 5–10° (R2), 10–15° (R3), 15–20° (R4), 20–25° (R5), and from retinal sectors (superior, nasal, inferior and temporal) between 0–15° and 0–25°. In the MS-ON-P Group, mean mfERG RADs detected from R1 (0–5°) and from the central nasal sector (0–15°) were significantly reduced (p < 0.01) with respect to those of the Control, MS-noON and MS-ON-G Groups. No other significant differences between Groups for any mfERG parameters were found. All Sd-OCT measurements, apart from the inner retina macular volume in the central 1 mm, were significantly reduced in MS-ON-P patients compared to Controls. The functional impairment in the MS-ON-P Group was associated but not correlated with structural changes of the outer and inner retinal layers in corresponding retinal Areas and Sectors. Our results suggest that in MS, exclusively after ON with poor recovery of BCVA, the neurodegenerative process can induce dysfunctional mechanisms involving photoreceptors and bipolar cells of the fovea and of the more central nasal macular area. MDPI 2020-11-22 /pmc/articles/PMC7700336/ /pubmed/33266435 http://dx.doi.org/10.3390/jcm9113766 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ziccardi, Lucia
Barbano, Lucilla
Boffa, Laura
Albanese, Maria
Nicoletti, Carolina Gabri
Landi, Doriana
Grzybowski, Andrzej
Falsini, Benedetto
Marfia, Girolama Alessandra
Centonze, Diego
Parisi, Vincenzo
Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis
title Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis
title_full Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis
title_fullStr Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis
title_full_unstemmed Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis
title_short Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis
title_sort functional assessment of outer and middle macular layers in multiple sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700336/
https://www.ncbi.nlm.nih.gov/pubmed/33266435
http://dx.doi.org/10.3390/jcm9113766
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